Imaging-based characterization of the COPDGene cohort
COPDGene 队列的基于成像的表征
基本信息
- 批准号:9127347
- 负责人:
- 金额:$ 71.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-01 至 2019-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAlveolarAnatomyCaringChronic Airflow ObstructionChronic Obstructive Airway DiseaseClinicalClinical TrialsCommunitiesDataDeteriorationDevelopmentDevicesDiagnosisDiffusionDiseaseEnvironmental air flowExhibitsFrequenciesFunctional disorderGasesGoldHealthHeterogeneityHybridsImageImaging TechniquesIonizing radiationLongitudinal StudiesLungMagnetic Resonance ImagingMapsMeasurementMeasuresMedicalMethodsModelingMonitorObstructive Lung DiseasesOutcomeOxygenPartial PressureParticipantPatient riskPatientsPhenotypePhysiologic pulsePhysiologicalPhysiologyPredispositionProtocols documentationPulmonary EmphysemaPulmonary Function Test/Forced Expiratory Volume 1Recording of previous eventsRecruitment ActivityReproducibilityResearchResolutionRespiratory physiologyScanningSiteSmokerSpirometryStructureSurrogate MarkersSymptomsSyndromeTechniquesTestingTidal VolumeTimeUniversitiesX-Ray Computed Tomographybaseclinically relevantcohortcostdisease heterogeneityfollow-upfunctional declinehuman subjectimaging agentimaging modalityimprovedlung volumemortalitynovelpulmonary functionrespiratorytreatment response
项目摘要
DESCRIPTION (provided by applicant): The global mortality of chronic obstructive pulmonary disease (COPD) continues to rise. Unfortunately, the predominant techniques for assessing its progression exhibit important shortcomings. Spirometry, the most commonly used surrogate marker in clinical trials, offers only global indications of functional alteration, and it has encountered substantial difficulty in sensitively and specifically assessing the heterogeneous abnormalities associated with COPD. While computed tomography (CT) produces excellent high-resolution images of key regional abnormalities, most of these images are anatomic and only indirectly related to physiology, and the exposure of patients to ionizing radiation can proscribe its use in longitudinal studies. To address these drawbacks, this project aims to refine and test a hyperpolarized gas magnetic resonance imaging (HP gas MRI) approach for the measurement of several important aspects of COPD pathophysiology in human subjects. The proposed method will allow for the simultaneous obtainment of three regional parameters that together offer a nuanced body of data on pulmonary physiology and microstructure: specific ventilation (SV), alveolar partial pressure of oxygen (pAO2), and apparent diffusion coefficient (ADC). The ability to extract all three of these metrics in a single acquisition period over multipe breaths confers several advantages. Most importantly, the use of a multi-breath sequence leads to more physiologically meaningful measurements. The simultaneous technique also results in inherent co-registration of all three parameters. Once the multi-breath HP MRI approach has been optimized, we will use it to study pulmonary function and structure in 120 COPD patients recruited from the Temple cohort of the COPDGene study. This cohort has already been well characterized by CT and spirometry. Our research on these subjects will first focus on correlating HP MRI metrics with these more established techniques. We will then compare HP MRI parameters with CT parameters in terms of their ability to predict whole-lung functional change, exacerbation frequency, and emphysematous remodeling over a two-year follow-up period. The broad impact of this research will be the development of a technique that can simultaneously derive multiple non-invasive markers of obstructive lung disease. These metrics will supply important physiologic data on the development and progression of COPD that will make a valuable contribution to the ongoing effort to better phenotype this protean disease. The parameters will also provide safe and sensitive markers for longitudinal studies of novel COPD therapies.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RAHIM R RIZI其他文献
RAHIM R RIZI的其他文献
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{{ truncateString('RAHIM R RIZI', 18)}}的其他基金
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10528137 - 财政年份:2022
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Imaging the functional response of the lung to bronchoscopic lung volume reduction
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10680458 - 财政年份:2022
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Predicting the onset of chronic rejection in lung transplant recipients using hyperpolarized 129Xe imaging
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The sixth international workshop on metabolic imaging
第六届代谢影像国际研讨会
- 批准号:
10063645 - 财政年份:2020
- 资助金额:
$ 71.06万 - 项目类别:
Predicting the onset of chronic rejection in lung transplant recipients using hyperpolarized 129Xe imaging
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- 批准号:
10407561 - 财政年份:2020
- 资助金额:
$ 71.06万 - 项目类别:
Improving lung transplant outcomes through the use of imaging in a DBD rat model
通过在 DBD 大鼠模型中使用成像来改善肺移植结果
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9764471 - 财政年份:2018
- 资助金额:
$ 71.06万 - 项目类别:
Improving lung transplant outcomes through the use of imaging in a DBD rat model
通过在 DBD 大鼠模型中使用成像来改善肺移植结果
- 批准号:
10198021 - 财政年份:2018
- 资助金额:
$ 71.06万 - 项目类别:
Prediction and assessment of COPD lung volume reduction outcomes with polarized MRI
使用偏振 MRI 预测和评估 COPD 肺减容结果
- 批准号:
9228404 - 财政年份:2016
- 资助金额:
$ 71.06万 - 项目类别:
Prediction and assessment of COPD lung volume reduction outcomes with polarized MRI
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9051246 - 财政年份:2016
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$ 71.06万 - 项目类别:
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9010971 - 财政年份:2015
- 资助金额:
$ 71.06万 - 项目类别:
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