POTENTIAL OF A NOVEL ANTI-PLATELET APTAMER IN OPTIMIZING ANTITHROMBOTIC
POTENTIAL OF A NOVEL ANTI-PLATELET APTAMER IN OPTIMIZING ANTITHROMBOTIC
批准号:
9061785
负责人:
Richard Clinton Becker
金额:
$24.92万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
已结题
起止时间:
至 2019-04-30
关键词:
Adverse effectsAnimal ModelAnticoagulant therapyAnticoagulantsAnticoagulationAntidotesBlood PlateletsBlood VesselsCardiopulmonary BypassCardiovascular systemCellsClinicalClinical TrialsCoagulantsCoagulation ProcessCutaneousDeep Vein ThrombosisDiseaseEnvironmentFunctional disorderGenerationsGoalsHealedHealthcareHemorrhageHemostatic AgentsHemostatic functionHeparinHospitalizationImpaired wound healingIn VitroInflammationInflammation MediatorsInflammatoryInflammatory ResponseInterventionMeasuresModelingMonitorOperative Surgical ProceduresOutcomePlatelet ActivationProceduresProductionPulmonary EmbolismQuality of lifeRattusResourcesRiskSafetyStimulusSurfaceTechnologyTestingTherapeuticTherapeutic InterventionThrombinThrombosisTimeTranslationsTraumaWorkWound Healingacute coronary syndromeangiogenesisaptamerbasecerebrovascularclinical practiceclinically relevantcritical periodexhaustionhealingimprovedimproved outcomein vivoinnovationnovelnovel therapeuticspreventprogramssynergismvon Willebrand Factor
中文摘要
深入和可控的抗凝在大量临床手术中是必不可少的,包括经皮和外科血管重建术(PCI和CABG),主动脉手术和其他血管干预。各种血栓性疾病,如急性冠状动脉综合征、肺栓塞或深静脉血栓形成,也需要立即抗凝治疗。所有这些干预和治疗的重大风险和副作用包括导致脑血管或心血管损害的深度出血或血栓形成。这些结果的临床和财务影响可能是深远的,并与住院时间延长、生活质量下降和卫生保健资源增加有关
英文摘要
Profound and controllable anticoagulation is essential during a large number of clinical procedures including percutaneous and surgical revascularization procedures (PCI and CABG), aortic surgery and other vascular interventions. Immediate anticoagulation therapy is also required in a variety of thrombotic diseases such as acute coronary syndromes, pulmonary embolism or deep vein thrombosis. Significant risks and side effects of all of these interventions and therapies include profound bleeding or thrombosis leading to cerebrovascular or cardiovascular compromise. The clinical and financial implications of these outcomes can be profound and are associated with prolonged hospitalization, reduced quality of life, and increased health-care resource
utilization. The proposed work extends the basic discoveries of novel therapeutic anticoagulant aptamer/antidote pairs. We believe that a crucial next step in the translation of these agents to clinical practice is the testing in predictive in vitro and animal models such as those we will employ in this project. The proposed work will reveal whether this innovative therapeutic strategy can provide superior anticoagulation in prothrombotic environments, while avoiding undesired effects such as bleeding, platelet dysfunction, systemic inflammation and impaired wound healing.
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会议论文
DEVELOPING A TRANSLATABLE PLATFORM FOR REVERSIBLE PLATELET INHIBITION
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批准号:8469091
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项目类别:
-
资助金额:$92.42万
-
财政年份:2013
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负责人:Richard Clinton Becker
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依托单位:
DTMI-Center for Thrombotic and Hemostatic Disorders
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批准号:8250552
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项目类别:
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资助金额:$220.59万
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财政年份:2012
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负责人:Richard Clinton Becker
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依托单位:
DTMI-Center for Thrombotic and Hemostatic Disorders
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批准号:8469084
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项目类别:
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资助金额:$220.67万
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财政年份:2012
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负责人:Richard Clinton Becker
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依托单位:
DTMI-Center for Thrombotic and Hemostatic Disorders
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批准号:8656777
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项目类别:
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资助金额:$226.91万
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财政年份:2012
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负责人:Richard Clinton Becker
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依托单位:
DTMI-Center for Thrombotic and Hemostatic Disorders
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批准号:8840627
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项目类别:
-
资助金额:$221.39万
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财政年份:2012
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负责人:Richard Clinton Becker
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依托单位:
ADMINISTRATAIVE CORE
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批准号:8391974
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项目类别:
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资助金额:$31.51万
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财政年份:--
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负责人:Richard Clinton Becker
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依托单位:
LABORATORY ASSESSMENT OF TARGETED ANTITHROMBOTIC THERAPIES
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批准号:8391973
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项目类别:
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资助金额:$31.51万
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财政年份:--
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负责人:Richard Clinton Becker
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依托单位:
ADMINISTRATAIVE CORE
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批准号:8469094
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项目类别:
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资助金额:$9.51万
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财政年份:--
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负责人:Richard Clinton Becker
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依托单位:
Translational Research Skills Development Core (TRSDC): Training Future Generati
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批准号:8469095
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项目类别:
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资助金额:$14.83万
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财政年份:--
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负责人:Richard Clinton Becker
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依托单位:
Translational Research Skills Development Core (TRSDC): Training Future Generati
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批准号:8656790
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项目类别:
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资助金额:$15.57万
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财政年份:--
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负责人:Richard Clinton Becker
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依托单位:
LABORATORY ASSESSMENT OF TARGETED ANTITHROMBOTIC THERAPIES
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批准号:8469093
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项目类别:
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资助金额:$31.55万
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财政年份:--
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负责人:Richard Clinton Becker
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依托单位:
POTENTIAL OF A NOVEL ANTI-PLATELET APTAMER IN OPTIMIZING ANTITHROMBOTIC
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批准号:8391971
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项目类别:
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资助金额:$31.51万
-
财政年份:--
-
负责人:Richard Clinton Becker
-
依托单位:
DEVELOPING A TRANSLATABLE PLATFORM FOR REVERSIBLE PLATELET INHIBITION
-
批准号:8391972
-
项目类别:
-
资助金额:$31.51万
-
财政年份:--
-
负责人:Richard Clinton Becker
-
依托单位:
DEVELOPING A TRANSLATABLE PLATFORM FOR REVERSIBLE PLATELET INHIBITION
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批准号:8840638
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项目类别:
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资助金额:$79.14万
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财政年份:--
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负责人:Richard Clinton Becker
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依托单位:
LABORATORY ASSESSMENT OF TARGETED ANTITHROMBOTIC THERAPIES
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批准号:8656788
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项目类别:
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资助金额:$32.4万
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财政年份:--
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负责人:Richard Clinton Becker
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依托单位:
MOLECULAR SYNTHESIS AND CHARACTERIZATION CORE (MSCC)
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批准号:8391976
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项目类别:
-
资助金额:$31.51万
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财政年份:--
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负责人:Richard Clinton Becker
-
依托单位:
POTENTIAL OF A NOVEL ANTI-PLATELET APTAMER IN OPTIMIZING ANTITHROMBOTIC
-
批准号:8469088
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项目类别:
-
资助金额:$27.61万
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财政年份:--
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负责人:Richard Clinton Becker
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依托单位:
Administrative Coordinating Center
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批准号:8469097
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项目类别:
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资助金额:$21.64万
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财政年份:--
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负责人:Richard Clinton Becker
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依托单位:
ADMINISTRATAIVE CORE
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批准号:8656789
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项目类别:
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资助金额:$10.22万
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财政年份:--
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负责人:Richard Clinton Becker
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依托单位:
POTENTIAL OF A NOVEL ANTI-PLATELET APTAMER IN OPTIMIZING ANTITHROMBOTIC
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批准号:8656786
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项目类别:
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资助金额:$26.25万
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财政年份:--
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负责人:Richard Clinton Becker
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依托单位:
海外基金