Participatory Research for Suicide Prevention in Autism

项目摘要/摘要 这是Anne Kirby博士的K23奖项申请，她是一名有执照的职业治疗师，在自闭症方面有专业知识， 独立进行翻译研究，以减少自闭症患者的自杀和提高生活质量 人民。K23将为她提供必要的支持，以获得四个关键职业发展中的关键技能 领域：1)与自闭症社区合作伙伴开展基于社区的参与性研究(CBPR)方法；2) 定性和混合方法研究方法；3)临床试验的有效性和实施情况 社区干预侧重于自杀预防；以及4)研究领导力和管理技能。至 为了实现她的目标，柯比博士组建了一个由希拉里·库恩博士组成的跨学科指导团队 (初级导师)，资深科学家和自闭症研究公认的领导者，以及三位共同导师：Dr。 克里斯蒂娜·尼古莱迪斯，一位研究自闭症成年人的有成就的CBPR研究员，苏珊·齐克蒙德博士， 定性和混合方法研究，以及领先的自杀预防临床试验专家克雷格·布莱恩博士。 作为对这些专家的补充，柯比博士还有一个由4名成员组成的咨询委员会来支持她提出的 CBPR与自闭症利益相关者合作，开发以社区为基础的自杀预防干预措施。 目前的证据表明，自闭症患者有自杀念头、自杀倾向的风险较高 行为，最终导致自杀死亡。自杀预防是自闭症成年人的高度优先事项，研究 是更好地了解危险因素和防止自杀所必需的。然而，很少有自闭症研究人员接受过培训 在有效地与自闭症社区合作方面。柯比博士的目标是解决当前 关于自杀和自闭症的知识，以及缺乏现有的循证自杀预防策略。 她的研究将产生初步数据，以支持一项临床试验，以测试一种新型的社区自杀 针对自闭症社区的预防干预。她提出了以下具体目标：目标1] 定性地探讨自闭症患者的自杀风险和保护因素，以及 循证自杀预防干预措施；目标2]发展以社区为基础的干预措施 PC CARE(促进社区关于结束自杀的研究的对话)模式框架 教育和增强自闭症社区利益相关者关于自闭症心理健康和自杀预防的知识； 和目标3]试点测试和细化干预内容、交付、效果和实施措施 为混合I型(疗效+实施)临床试验做准备。这项提议的一个关键组成部分 将在整个拟议目标中使用CBPR方法，以确保社区相关性和 可接受性。 这项拟议的研究意义重大，因为它扩大了我们对自闭症患者自杀风险的理解。 拟议的研究具有创新性，因为它采用了CBPR方法，并将产生第一个社区- 自闭症社区为自闭症社区开发的基于自杀的预防方法。

PROJECT SUMMARY/ABSTRACT This is a K23 award application for Dr. Anne Kirby, a licensed occupational therapist with expertise in autism, to independently conduct translational research studies to reduce suicide and advance quality of life for autistic people. The K23 will provide her the support necessary to acquire critical skills in four key career development areas: 1) community-based participatory research (CBPR) approaches with autistic community partners; 2) qualitative and mixed methods research approaches; 3) efficacy and implementation clinical trials of community interventions focused on suicide prevention; and 4) research leadership and management skills. To achieve her goals, Dr. Kirby has assembled an interdisciplinary mentoring team comprised of Dr. Hillary Coon (Primary Mentor), a senior scientist and recognized leader in autism research, and three Co-Mentors: Dr. Christina Nicolaidis, an accomplished CBPR researcher with autistic adults, Dr. Susan Zickmund, an expert in qualitative and mixed methods research, and Dr. Craig Bryan, a leading suicide prevention clinical trialist. Complementing these experts, Dr. Kirby also has a 4 member advisory committee to support her proposed CBPR work with autistic stakeholders and development of a suicide prevention community-based intervention. Current evidence demonstrates that autistic individuals are at elevated risk for suicidal thoughts, suicidal behaviors, and, ultimately, suicide deaths. Suicide prevention is a high priority of autistic adults, and research is needed to better understand risk factors and prevent suicide. However, few autism researchers are trained in working effectively with the autistic community. Dr. Kirby's objective is to address the gaps in current knowledge about suicide and autism, and the lack of available evidence-based suicide prevention strategies. Her research will result in preliminary data to support a clinical trial to test a novel community-based suicide prevention intervention for autism communities. She proposes the following Specific Aims: Aim 1] Qualitatively explore suicide risk and protective factors for autistic people as well as preferred aspects of evidence-based suicide prevention interventions; Aim 2] Develop a community-based intervention built upon the PC CARES (Promoting Community Conversations About Research to End Suicide) model framework to educate and empower autism community stakeholders about autistic mental health and suicide prevention; and Aim 3] Pilot test and refine the intervention content, delivery, and efficacy and implementation measures in preparation for a Hybrid Type 1(efficacy + implementation) clinical trial. A critical component of this proposal will be the use of CBPR methods throughout the proposed aims to ensure community relevance and acceptability. The proposed research is significant because it expands our understanding of suicide risk in autistic people. The proposed research is innovative because it takes a CBPR approach and will result in the first community- based suicide prevention approach developed by and for the autistic community.