Social-ecological factors influencing receptivity to Zika virus and the efficacy of interventions in communities along the Texas-Mexico border

影响寨卡病毒接受度的社会生态因素以及德克萨斯州-墨西哥边境社区干预措施的有效性

• 批准号: 9252730
• 负责人: Gabriel Lee Hamer
• 金额: $ 22.28万
• 依托单位: TEXAS A&M AGRILIFE RESEARCH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2018-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9252730
• 关键词: Address; Adult; Aedes; Area; Blood Circulation; Breeding; Centers for Disease Control and Prevention (U.S.); Chikungunya virus; Communities; Community Participation; County; Culex (Genus); Culicidae; Dengue; Dengue Virus; Development; Dimensions; Disease Management; Disease Outbreaks; Environment; Experimental Designs; Exposure to; Frequencies; Goals; Gravid; Gravidity; Habitats; Home environment; Human; Income; Intervention; Latino; Link; Location; Mexico; Monitor; Morbidity - disease rate; Mosaicism; Mosquito Control; Mosquito-borne infectious disease; Neighborhoods; Outcome; Oviposition; Permeability; Population; Predictive Factor; Pregnancy Complications; Property; Public Health; Research; Risk; Risk Factors; Sampling; Sentinel; Socioeconomic Factors; South Texas; Syndrome; Testing; Texas; Treatment Efficacy; United States; Variant; Vector-transmitted infectious disease; Viral; Virus; West Nile virus; Zika Virus; base; citizen science; disease transmission; disorder risk; effective intervention; exposed human population; indoor exposure; life history; neglect; novel; pathogen; programs; response; social; socioeconomics; success; sugar; tool; translational impact; transmission process; vector; vector control; vector mosquito; viral transmission

PROJECT SUMMARY The global emergence of Dengue virus (DENV), Chikunguyna virus (CHIKV) and Zika virus (ZIKV) demonstrate the ability of mosquito-borne viruses to spread around the world and result in significant public health burden. These viruses are maintained in urban transmission cycles and the ability of the virus to persist depends on the ecological receptivity of the environment that depends largely on the frequency of mosquito-human contact. Additionally, the ability of a community-based intervention with engaged citizens activity participating in integrated mosquito management is determined by cultural and socioeconomic factors. These social-ecological factors that modulate mosquito-borne viral risk and efficacy of management have not been fully appreciated or addressed in the continental United States. Our central hypothesis is that different communities vary starkly in their ecological receptivity to transmission and capacity to respond to outbreaks as a result of social factors. This hypothesis will be tested by the following Specific Aims: 1) quantify indoor and outdoor mosquito species presence and abundance and identify risk factors associated with indoor mosquito populations, 2) evaluate the efficacy of the CDC Autocidal Gravid Ovitrap (AGO)-based vector control on mosquito abundance across communities and between different vector species (Aedes aegypti, Aedes albopictus, Culex quinquefasciatus), 3) identify factors that predict community participation in citizen science campaigns and acquiescence to implement vector control strategies. This study will occur in eight communities in South Texas (Hidalgo and Cameron Counties) using a paired plot experimental design. We will monitor adult mosquito abundance using a novel application of a sugar bait station that determines the species and relative abundance of the primary mosquito vector species. This new sampling strategy will be compared to the Sentinel AGO trap, which is an established tool to monitor adult mosquito abundance. The expected outcomes include 1) a better assessment of the emergence risk for viruses like ZIKV and CHIKV that are amplified in a human-mosquito cycles in U.S. communities, 2) a critical assessment of indoor exposure risk in U.S. communities, and 3) determining the necessity to adapt disease management strategies to specific social-ecological factors endemic to local communities. This research addresses the need for diverse mitigation strategies that should be employed across landscape mosaics of different communities of variable socioeconomic levels that present distinct challenges to limit vector-borne disease transmission. Ultimately, the research is expected to have a positive translational impact on the development of integrated mitigation strategies that effectively engage local communities for rapid response to emerging viral threats.

项目摘要 登革热病毒（DENV）、基孔圭纳病毒（CHIKV）和寨卡病毒（ZIKV）的全球出现 证明了蚊子传播的病毒在世界各地传播的能力， 公共卫生负担。这些病毒维持在城市传播周期中， 病毒的持续存在取决于环境的生态接受能力，而环境的生态接受能力在很大程度上取决于 蚊子与人接触的频率。此外，基于社区的干预能力， 参与蚊子综合管理的公民活动取决于文化 和社会经济因素。这些调节蚊媒病毒风险的社会生态因素 管理的有效性和效率尚未得到充分的认识或解决在大陆联合国 States.我们的中心假设是，不同的社区在生态接受性方面存在明显差异 传播和应对疫情的能力。这一假设将 通过以下具体目的进行测试：1）量化室内和室外蚊子物种的存在 和丰度，并确定与室内蚊子种群相关的风险因素，2）评估 基于CDC Autocidal Gravid Ovitrap（AGO）的病媒控制对蚊子数量的有效性 跨社区和不同病媒物种（埃及伊蚊、白纹伊蚊、库蚊）之间 quinquefasciatus），3）确定预测社区参与公民科学运动的因素 并默许实施病媒控制策略。这项研究将在八个社区进行， 南德克萨斯州（伊达尔戈县和卡梅隆县）采用配对小区试验设计。我们将 使用糖诱饵站的新应用监测成年蚊子的丰度， 主要蚊媒物种的种类和相对丰度。这个新的采样 战略将比较哨兵AGO陷阱，这是一个既定的工具，监测成人 蚊子多。预期成果包括：1）更好地评估突发事件风险 对于像ZIKV和CHIKV这样在美国社区的人-蚊子循环中扩增的病毒， 2)对美国社区的室内暴露风险进行严格评估，以及3）确定 使疾病管理战略适应当地特有的社会生态因素， 社区.这项研究解决了需要不同的缓解战略，应该是 在不同社会经济水平的不同社区的景观马赛克中使用， 对限制病媒传播疾病的传播提出了独特的挑战。最终，这项研究 预计将对制定综合缓解战略产生积极的转化影响 有效地动员当地社区对新出现的病毒威胁作出快速反应。