Pediatric Cardiovascular and Pulmonary Research Training Program

 描述(由申请人提供)：这是一项新的申请或培训计划，旨在吸引和培训博士后和博士后研究人员进行与心血管和肺部生物学相关的儿童疾病基础研究。对心血管和肺部疾病的细胞/分子基础的培训计划的需要，特别是对儿童疾病感兴趣的内科科学家，是基于明确的证据，即像教员或实习生这样的人在全国范围内很少。目前，美国医学中心的儿科心脏病学或肺科奖学金项目很少在这一研究领域提供足够的培训，无论是在长凳上还是在结构化的临床调查中。我们的 该计划旨在从两个重要角度满足这一需求：1)允许对基础研究感兴趣的儿科和其他临床研究员发展研究能力和职业培训；2)吸引和培养有才华的基础科学家研究与儿童疾病有关的机制。我们的计划重组反映了对培训计划的重新思考，该计划16年来成功地培训了基础和临床研究领域的科学家和临床医生。这一新项目是根据前一个项目评审员的反馈意见、我们的教职员工和项目顾问的建议、过去的学员以及华盛顿大学新的核心项目的形成而形成的，这些项目使我们能够扩大学员的培训经验。除了继续我们在发育/细胞生物学和疾病分子基础方面的强大培训外，我们的新项目还将利用遗传学、干细胞生物学、基因组学和生物信息学方面的机构优势--所有这些都是现代研究基础的组成部分。我们采用了4个博士后(多个PGY级别)和2个博士后研究员的培训课程，并不间断地进行2-3年的全日制研究。这与一套综合的、多学科的教学研讨会、杂志俱乐部和正式课程相结合，这些课程由学员与导师/项目管理人员协商选择，以提供心肺发育和疾病关键方面的个性化教育。我们的目标是：1)为学员提供广泛的职业发展指导，并制定专注于儿科疾病的独立研究计划；2)促进基础细胞和分子生物学、基因组学、生物信息学以及临床转化研究方面的培训；3)指导学员的发展，以便在培训完成后，有可能成功竞争独立资金。

 DESCRIPTION (provided by applicant): This is a new application or a training program designed to attract and train both predoctoral and postdoctoral investigators in basic investigation of childhood diseases related to cardiovascular and pulmonary biology. The need for a training program in the cellular/molecular basis of cardiovascular and pulmonary disease, especially of physician scientists interested in childhood diseases, is based upon clear evidence of a small, national pool of such individuals as faculty or trainees. Currently, few pediatric cardiology or pulmonary fellowship programs in American medical centers provide adequate training in this area of research, either at the bench or in structured clinical investigation. Our program is designed to address this need from two important perspectives: 1) To allow pediatric and other clinical fellows with an interest in basic research to develop research competence and career training; 2) To attract and train talented basic scientists to study mechanism related to childhood diseases. Our program restructuring reflects a rethinking of a training program that for 16 years successfully trained scientists and clinicians in areas of basic and clinical research. This new program has been shaped by feedback from reviewers of the previous program, by advice from our faculty and program advisors, by past trainees, and by the formation of new core programs at Washington University that allow us to expand the training experience of our trainees. In addition to continuing our strong training in developmental/cell biology and the molecular basis of disease, our new program will take advantage of institutional strengths in genetics, stem cell biology, genomics, and bioinformatics-all of which are components of the foundation of modern research. We have adopted a training curriculum for 4 postdoctoral (multiple PGY levels) and 2 predoctoral fellows with an uninterrupted 2-3 year block of full-time investigation. This is combined with an integrated and multidisciplinary set of didactic seminars, journal clubs and formal courses that are selected by the trainee in consultation with the mentor/program administrators to provide individualized education in key aspects of cardiopulmonary development and disease. Our objectives are: 1) to provide extensive mentoring to the trainee for career development and for developing independent research plans that focus on pediatric diseases; 2) to promote training in basic cell and molecular biology, genomics, and bioinformatics together with clinical translational research; 3) to guide the trainees' development so that, after the completion of training, successful competition for independent funding is likely.