Pediatric Cardiovascular and Pulmonary Research Training Program

 描述（由申请人提供）：这是一个新的应用程序或培训计划，旨在吸引和培训博士前和博士后研究人员在基础研究的儿童疾病相关的心血管和肺生物学。心血管和肺部疾病的细胞/分子基础的培训计划，特别是对儿童疾病感兴趣的医生科学家的需要，是基于一个小的，全国性的教师或学员等个人的明确证据。目前，在美国的医疗中心，很少有儿科心脏病学或肺奖学金计划提供足够的培训，在这一领域的研究，无论是在板凳上或结构化的临床研究。我们 该计划旨在从两个重要方面解决这一需求：1）允许对基础研究感兴趣的儿科和其他临床研究员发展研究能力和职业培训; 2）吸引和培养有才华的基础科学家研究与儿童疾病相关的机制。我们的计划重组反映了对培训计划的重新思考，该培训计划在基础和临床研究领域成功培训了16年的科学家和临床医生。这个新的程序已经形成了从以前的程序的评审员的反馈，从我们的教师和程序顾问的建议，由过去的学员，并在华盛顿大学，使我们能够扩大我们的学员的培训经验的新的核心计划的形成。除了继续我们在发育/细胞生物学和疾病的分子基础方面的强大培训外，我们的新计划将利用遗传学，干细胞生物学，基因组学和生物信息学的机构优势，所有这些都是现代研究基础的组成部分。我们采用了4个博士后（多个PGY水平）和2个博士前研究员的培训课程，为期2-3年的全职研究。这与一套综合的多学科教学研讨会，期刊俱乐部和正式课程相结合，这些课程由受训者与导师/项目管理人员协商选择，以提供心肺发育和疾病关键方面的个性化教育。我们的目标是：1）为学员的职业发展和制定专注于儿科疾病的独立研究计划提供广泛的指导; 2）促进基础细胞和分子生物学、基因组学和生物信息学的培训以及临床转化研究; 3）指导学员的发展，以便在完成培训后成功竞争独立资助。

 DESCRIPTION (provided by applicant): This is a new application or a training program designed to attract and train both predoctoral and postdoctoral investigators in basic investigation of childhood diseases related to cardiovascular and pulmonary biology. The need for a training program in the cellular/molecular basis of cardiovascular and pulmonary disease, especially of physician scientists interested in childhood diseases, is based upon clear evidence of a small, national pool of such individuals as faculty or trainees. Currently, few pediatric cardiology or pulmonary fellowship programs in American medical centers provide adequate training in this area of research, either at the bench or in structured clinical investigation. Our program is designed to address this need from two important perspectives: 1) To allow pediatric and other clinical fellows with an interest in basic research to develop research competence and career training; 2) To attract and train talented basic scientists to study mechanism related to childhood diseases. Our program restructuring reflects a rethinking of a training program that for 16 years successfully trained scientists and clinicians in areas of basic and clinical research. This new program has been shaped by feedback from reviewers of the previous program, by advice from our faculty and program advisors, by past trainees, and by the formation of new core programs at Washington University that allow us to expand the training experience of our trainees. In addition to continuing our strong training in developmental/cell biology and the molecular basis of disease, our new program will take advantage of institutional strengths in genetics, stem cell biology, genomics, and bioinformatics-all of which are components of the foundation of modern research. We have adopted a training curriculum for 4 postdoctoral (multiple PGY levels) and 2 predoctoral fellows with an uninterrupted 2-3 year block of full-time investigation. This is combined with an integrated and multidisciplinary set of didactic seminars, journal clubs and formal courses that are selected by the trainee in consultation with the mentor/program administrators to provide individualized education in key aspects of cardiopulmonary development and disease. Our objectives are: 1) to provide extensive mentoring to the trainee for career development and for developing independent research plans that focus on pediatric diseases; 2) to promote training in basic cell and molecular biology, genomics, and bioinformatics together with clinical translational research; 3) to guide the trainees' development so that, after the completion of training, successful competition for independent funding is likely.