Neurobehavioral Predictors of Emotional Deficits in Youth at Risk for Depression

有抑郁风险的青少年情绪缺陷的神经行为预测因素

• 批准号: 9282638
• 负责人: Lauren M Bylsma
• 金额: $ 15.72万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2018-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9282638
• 关键词: 13 year old; Address; Adolescence; Affective; Archives; Attention; Behavior; Behavioral; Brain; Childhood; Clinical Data; Clinical assessments; Cognitive; Data; Depressed mood; Development; Developmental Process; Disease; Ecological momentary assessment; Emotional; Emotions; Environment; Event-Related Potentials; Exhibits; Family; Feedback; Foundations; Functional disorder; Gender; Goals; Individual; Informal Social Control; Intervention; Laboratories; Life; Longitudinal Studies; Measures; Mental Depression; Mental Health; Mentorship; Methodology; Methods; Monitor; Mood Disorders; Motivation; National Institute of Mental Health; Parents; Performance; Prevention; Preventive Intervention; Process; Protocols documentation; Psychiatry; Psychopathology; Regulation; Research; Research Personnel; Research Training; Rewards; Risk; Sampling; Silk; Social Environment; Stimulus; System; Systems Development; Time; Training; Universities; Work; Youth; affective neuroscience; base; brain behavior; career; child depression; clinically significant; depressive symptoms; design; early onset; emotion regulation; emotional reaction; emotional stimulus; experience; flexibility; follow-up; high risk; improved; indexing; innovation; longitudinal analysis; longitudinal course; longitudinal design; medical schools; multilevel analysis; negative affect; neural circuit; neural correlate; neurobehavioral; neurodevelopment; neuromechanism; offspring; peer; positive emotional state; public health relevance; relating to nervous system; research study; response; stressor; trait

DESCRIPTION (provided by applicant): Depression rates dramatically increase during adolescence when offspring of depressed parents are 3-4 times more vulnerable compared to their peers. Adolescence is a sensitive period in the development of neural circuits supporting cognitive-affective processes involved in emotion processing and regulation. Research has implicated motivational and emotional deficits in depression. Emotions are based on a motivational system that guides an individual to adaptively and flexibly respond to features of the environment. However, little is known regarding the development of neural correlates involved in processing emotionally salient information that may be implicated in depression vulnerability or how these neural correlates relate to the development of depression symptoms over time. Further, it is largely unknown how these neural mechanisms correspond to real world behaviors, which is key to understanding their clinical significance and developing targeted treatments. The candidate proposes to examine neurobehavioral markers of emotional processing and regulation in a sample of 45 youth at high risk for depression (by virtue of having a parent with early onset depression) and 45 low risk peers. These youth and their families have already been followed extensively through Dr. Maria Kovacs' longitudinal childhood depression research studies from which extensive archival clinical data is available. In an innovative design, the candidate will examine neural indices of emotional processing using Event Related Potentials (ERPs), with a focus on the Late Positive Potential (LPP) and Feedback Negativity (FN). The candidate will integrate these neural indices with a 9-day Ecological Momentary Assessment (EMA) protocol of emotional reactions and regulation responses in daily life in order to identify brain-behavior relationships involved in emotional processing. Aim 1 will examine the extent to which high risk youth exhibit altered LPP and FN in response to emotional processing and regulation tasks. Aim 2 will examine the degree to which high and low risk youth differ on their emotional reactions and regulation responses in daily life. Aim 2 will also determine the brain-behavior relationships between neural and daily life indices of emotion. Aim 3 will examine the extent to which neural and daily life measures of emotion predict the longitudinal course of depressive symptoms over a 1-year follow-up. The candidate's long-term career goal is to become an independent investigator with expertise in the developmental affective neuroscience of depression. To address the research and training aims of this proposal, the candidate seeks to build upon her strong foundation in the experimental psychopathology of emotion through the following training aims: 1) gain conceptual expertise in developmental affective neuroscience; 2) achieve a deeper understanding of the clinical assessment of youth and developmental aspects of depression, including use of longitudinal high risk designs; 3) gain a deeper methodological expertise in collecting, processing, and analyzing ERP data of emotional processing in youth; and 4) achieve methodological expertise in collecting, processing, and analyzing EMA data measuring emotional responding and regulation in youth, including the conceptual and technical ability to integrate daily life measure with neural indices. The Department of Psychiatry at the University of Pittsburgh School of Medicine is an outstanding environment in which to engage in interdisciplinary training and integrative research necessary to achieve these research and training goals. The candidate's mentorship team (Drs. Ladcouer, Silk, and Kovacs) and consultant team (Drs. Hajcak Proudfit, Kuppens, and Wallace) have extensive experience in developmental affective neuroscience methods (including use of ERP methods), longitudinal high risk designs, use of EMA methods to examine emotion in daily life, conceptual and practical issues in measuring emotion regulation, and statistical expertise in multilevel and longitudinal analyses. The proposed study is the first to integrate neurobehavioral measures in a longitudinal design with youth at high risk for depression before they experience their first depressive episode. Findings will inform the design of larger R01 studies to examine bi-directional brain-behavior relationships, to elucidate specific developmental processes related to gender and social environment of high risk youth, and to identify specific targets for intervention and prevention of pediatric mood disorders. In conclusion, the proposed K01 application would provide the candidate with the training and research background to conduct independent research that integrates developmental and neurobehavioral affective neuroscience approaches to understand mechanisms underlying emotional dysfunction in youth vulnerable to developing depression.

描述（由申请人提供）：在青春期，抑郁父母的后代比同龄人更容易受到3-4倍的伤害，抑郁率急剧增加。青少年时期是支持情绪加工和调节的认知情感过程的神经回路发育的敏感时期。研究表明，抑郁症与动机和情感缺陷有关。情绪是基于一个激励系统，引导个人适应性和灵活地应对环境的特点。然而，很少有人知道有关的神经相关的发展参与处理情绪上的显着信息，可能涉及抑郁症的脆弱性或如何这些神经相关的抑郁症症状的发展，随着时间的推移。此外，这些神经机制如何对应于真实的世界行为在很大程度上是未知的，这是理解其临床意义和开发靶向治疗的关键。 候选人建议在45名抑郁症高危青年（凭借父母患有早发性抑郁症）和45名低风险同龄人的样本中检查情绪处理和调节的神经行为标志物。这些青少年和他们的家庭已经通过玛丽亚·科瓦奇博士的纵向儿童抑郁症研究进行了广泛的跟踪，从这些研究中可以获得大量的临床档案数据。在创新的设计中， 考生将使用事件相关电位（ERP）检查情绪处理的神经指标，重点是后期正电位（LPP）和反馈负电位（FN）。候选人将这些神经指标与日常生活中的情绪反应和调节反应的9天生态瞬时评估（EMA）协议相结合，以确定涉及情绪处理的大脑行为关系。目的1将研究在何种程度上，高风险的青年表现出改变LPP和FN在情绪处理和调节任务。目标二将探讨高危青少年和低危青少年在日常生活中的情绪反应和调节反应的差异程度。目标2还将确定神经和日常生活情绪指数之间的脑行为关系。目标3将检查在何种程度上神经和日常生活措施的情绪预测纵向过程中的抑郁症状超过1年的随访。 候选人的长期职业目标是成为一名独立的研究人员，在抑郁症的发展情感神经科学方面具有专业知识。为了实现这一建议的研究和培训目标，候选人寻求通过以下培训目标建立在她在情感实验精神病理学方面的坚实基础上：1）获得发展情感神经科学的概念专业知识; 2）更深入地了解青年和抑郁症发展方面的临床评估，包括使用纵向高风险设计; 3）在收集，处理和分析青少年情绪加工的ERP数据方面获得更深的方法学专业知识; 4）在收集，处理和分析测量青少年情绪反应和调节的EMA数据方面获得方法学专业知识，包括将日常生活测量与神经指标相结合的概念和技术能力。 匹兹堡大学医学院精神病学系是一个优秀的环境，可以从事实现这些研究和培训目标所必需的跨学科培训和综合研究。候选人的导师团队（Ladcouer、Silk和Kovacs博士）和顾问团队（Hajcak Proudfit，Kuppens和Wallace博士）在发展情感神经科学方法方面具有丰富的经验（包括使用ERP方法），纵向高风险设计，使用EMA方法检查日常生活中的情绪，测量情绪调节的概念和实践问题，以及多层次和纵向分析的统计专业知识。 这项研究是第一个 在一项纵向设计中，在抑郁症高危青年首次出现抑郁症发作之前，将神经行为测量整合在一起。研究结果将为更大规模的R 01研究设计提供信息，以检查双向脑行为关系，阐明特定的 发展过程有关的性别和社会环境的高危青少年，并确定具体目标的干预和预防儿童情绪障碍。总之，拟议的K 01应用程序将为候选人提供培训和研究背景，以进行独立的研究，整合发展和神经行为情感神经科学方法，以了解易患抑郁症的青少年情绪功能障碍的机制。

项目成果

The Riddle of Human Emotional Crying: A Challenge for Emotion Researchers.

人类情感哭泣之谜：情感研究人员的挑战。

• DOI: 10.1177/1754073915586226
• 发表时间: 2016
• 期刊: Emotion review : journal of the International Society for Research on Emotion
• 作者: Vingerhoets,AdJJM;Bylsma,LaurenM
• 通讯作者: Bylsma,LaurenM

Adolescent girls' intrapersonal and interpersonal parasympathetic regulation during peer support is moderated by trait and state co-rumination.

• DOI: 10.1002/dev.22232
• 发表时间: 2022-01
• 期刊: Developmental psychobiology
• 影响因子: 2.2
• 作者: Stone LB;Silk JS;Lewis G;Banta MC;Bylsma LM
• 通讯作者: Bylsma LM

Is the Divide a Chasm?: Bridging Affective Science with Clinical Practice.

• DOI: 10.1007/s10862-015-9525-7
• 发表时间: 2016-03
• 期刊: Journal of psychopathology and behavioral assessment
• 影响因子: 1.6
• 作者: Bylsma LM;Mauss IB;Rottenberg J
• 通讯作者: Rottenberg J

The neurobiology of human crying.

• DOI: 10.1007/s10286-018-0526-y
• 发表时间: 2019-03
• 期刊: Clinical autonomic research : official journal of the Clinical Autonomic Research Society
• 作者: Bylsma LM;Gračanin A;Vingerhoets AJJM
• 通讯作者: Vingerhoets AJJM