Biomagnetic Liver Susceptometry based on Piezoelectric Magnetic Sensors

铁超载影响着美国和世界各地许多人的生活。肝脏铁

Iron overload affects life of many people in the US and around the world. Liver iron concentration provides a direct indicator of body iron level. Among various noninvasive methods, Biomagnetic liver susceptometry (BLS) has been proven to provide the only direct means of determining hepatic iron stores. However, BLS requires cost-prohibitive (~ 1 million) and complex (~ 4 K, liquid helium) SQUID magnetometer, which limits the clinical adoption of this technology. The objective of this SBIR project is to develop a low-cost, compact-size, and portable room temperature biomagnetic liver susceptometry (PM BLS) based on piezoelectric biomagnetic sensor for general clinical use to quickly, easily, noninvasively, and quantitatively assess liver iron concentration. The proposed effort explores the unique opportunity afforded by recent advances in piezo-magnetic sensors that exhibit ultra-high AC magnetic sensitivity in the presence of strong DC magnetic background and breakthrough at Prof. Zhang’s laboratory of Penn State University (PSU) in successful demonstration of the performance of piezo-magnetic sensor using liver phantoms. Specifically, Nascent Devices LLC proposes to develop a piezoelectric magnetic (PM) sensor susceptometer and carry out a direct comparison with the SQUID BLS at UCSF Benioff Children’s Hospital Oakland, CA. In Aim 1, we will develop a compact PM sensor susceptometry, a first order gradiometer configuration and ready for clinical study. In Aim 2, we will carry out calibration of the PM sensors with Liver phantoms of different iron concentrations and compared with computer simulation results. In Aim 3, direct comparison of the first order PM biomagnetic susceptometry with the SQUID BLS on human subjects. Available test results reveal that our PM BLS will have equal or better sensitivity to SQUID BLS in assessing liver iron concentration (LIC) due to closer distance to the liver, improved SNR at higher scan rate, and greater flexibility and mobility with much lower cost (< $5,000). The PM BLS technology to be developed in this program is both “conventional” and “disruptive”. It is conventional because this technology will adopt the principle of SQUID- based BLS which has been proven to be effective in quantifying LIC. It is disruptive because the technology can lead to breakthroughs in cost and size, which would lead to the development of a portable physician clinics’ or patient bed-side BLS device in the future SBIR Phase II and Phase III applications.