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Quantification and modeling of the emergence of tissue-level mechanics from individual cell heterogeneity

Quantification and modeling of the emergence of tissue-level mechanics from individual cell heterogeneity
对个体细胞异质性组织水平力学的出现进行量化和建模
批准号:
9135441
负责人:
SCOTT A HOLLEY
金额:
$39.33万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-09-30 至 2017-08-31

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中文摘要
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英文摘要
 DESCRIPTION: The proposed research pioneers the study of the dynamic interrelationship between in vivo heterogeneous individual cell behavior and systems-level tissue properties. The project employs multiplex in vivo single cell imaging and computational analyses of tailbud cell motion to elucidate the mechanical basis of both normal vertebrate body elongation and structural musculoskeletal defects such as scoliosis. A central hypothesis of this proposal is that key systems properties of developing tissues, such as the correlation length of cell motion and cell packing, are under genetic regulation to enable robust control of symmetry maintenance and symmetry breaking. To uncover the general design principles of such regulation, the team will combine zebrafish genetics and live imaging with single cell resolution with analytical and computational tools from fluid mechanics and soft matter physics. Using this interdisciplinary approach, the team will create a 4D computational model (3D with time evolution) of the extending zebrafish tailbud incorporating cell-cell interactions, cell motion, cell packing and dynamic tissue boundaries. By comparing and contrasting the wild-type cell flow and contorted phenotypes, the team will produce a better understanding of the physical parameters that must be genetically regulated for linear body elongation. In other words, the experimental and computational systems analysis of cell motion will integrate genetics and multi-scale mechanics (i.e. molecular, cell and tissue level) into a unified ontogeny of abnormal curvatures of the spina column.
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The systems developmental biology of zebrafish body elongation
  • 批准号:
    10806332
  • 项目类别:
  • 资助金额:
    $3.25万
  • 财政年份:
    2023
  • 负责人:
    SCOTT A HOLLEY
  • 依托单位:
The systems developmental biology of zebrafish body elongation
  • 批准号:
    10552318
  • 项目类别:
  • 资助金额:
    $63.23万
  • 财政年份:
    2023
  • 负责人:
    SCOTT A HOLLEY
  • 依托单位:
The Molecular Biophysics and Tissue Biomechanics of Somite Morphogenesis
  • 批准号:
    9896870
  • 项目类别:
  • 资助金额:
    $38.36万
  • 财政年份:
    2018
  • 负责人:
    SCOTT A HOLLEY
  • 依托单位:
The cross-scale biomechanics of tissue morphogenesis
  • 批准号:
    9363434
  • 项目类别:
  • 资助金额:
    $41.88万
  • 财政年份:
    2017
  • 负责人:
    SCOTT A HOLLEY
  • 依托单位:
海外基金