The systems developmental biology of zebrafish body elongation

斑马鱼身体伸长的系统发育生物学

基本信息

  • 批准号:
    10806332
  • 负责人:
  • 金额:
    $ 3.25万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-01-01 至 2027-12-31
  • 项目状态:
    未结题

项目摘要

This research program focuses on the systems developmental biology, biophysics and biomechanics of early spinal column development. The research program utilizes zebrafish as model for understanding the mechanisms of human development and causes of birth defects such as scoliosis and spina bifida. The experimental approach is driven by the idea that quantitative in vivo analysis will lead to fundamental insights into the emergence of biological organization from the collective interaction of its constituent parts. The research program combines genetics, embryology, in vivo biophysics, live imaging and systems level data analysis and computational modeling to study pattern formation and morphogenesis. The proposed research program will address a number of questions regarding biological order and the reproducibility of embryonic development. The program will follow-up on the lab’s recent finding that a dynamically stable pattern of cell state transitions underlies the reproducibility of development to understand the mechanisms maintaining dynamic stability during zebrafish body elongation. The research program will also examine the mechanism of mechanical information regulating the flux of cells through a developmental trajectory. The program will address how tissue-tissue interactions constrain cell behavior during body elongation. At the molecular and cellular level, the program will utilize newly developed methods for in vivo single molecule biophysics to study cell adhesion protein dynamics and their relation to cell state transitions and cell morphology. Overall, this is multi-scale research program that considers the roles of molecules, cells and tissues in the genesis of order in the developing embryo.
本研究计划的重点是系统发育生物学,生物物理学和

项目成果

期刊论文数量(1)
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专利数量(0)

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SCOTT A HOLLEY其他文献

SCOTT A HOLLEY的其他文献

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{{ truncateString('SCOTT A HOLLEY', 18)}}的其他基金

The systems developmental biology of zebrafish body elongation
斑马鱼身体伸长的系统发育生物学
  • 批准号:
    10552318
  • 财政年份:
    2023
  • 资助金额:
    $ 3.25万
  • 项目类别:
The Molecular Biophysics and Tissue Biomechanics of Somite Morphogenesis
体节形态发生的分子生物物理学和组织生物力学
  • 批准号:
    9896870
  • 财政年份:
    2018
  • 资助金额:
    $ 3.25万
  • 项目类别:
The cross-scale biomechanics of tissue morphogenesis
组织形态发生的跨尺度生物力学
  • 批准号:
    9363434
  • 财政年份:
    2017
  • 资助金额:
    $ 3.25万
  • 项目类别:
The cross-scale biomechanics of tissue morphogenesis
组织形态发生的跨尺度生物力学
  • 批准号:
    9557529
  • 财政年份:
    2017
  • 资助金额:
    $ 3.25万
  • 项目类别:
Quantification of the mechanics of vertebrate body elongation
脊椎动物身体伸长力学的量化
  • 批准号:
    8837030
  • 财政年份:
    2014
  • 资助金额:
    $ 3.25万
  • 项目类别:
Quantification of the mechanics of vertebrate body elongation
脊椎动物身体伸长力学的量化
  • 批准号:
    8695630
  • 财政年份:
    2014
  • 资助金额:
    $ 3.25万
  • 项目类别:
Quantification of the mechanics of vertebrate body elongation
脊椎动物身体伸长力学的量化
  • 批准号:
    9043110
  • 财政年份:
    2014
  • 资助金额:
    $ 3.25万
  • 项目类别:
Quantification and modeling of the emergence of tissue-level mechanics from individual cell heterogeneity
对个体细胞异质性组织水平力学的出现进行量化和建模
  • 批准号:
    9135441
  • 财政年份:
    2014
  • 资助金额:
    $ 3.25万
  • 项目类别:
Quantification and modeling of the emergence of tissue-level mechanics from individual cell heterogeneity
对个体细胞异质性组织水平力学的出现进行量化和建模
  • 批准号:
    8934125
  • 财政年份:
    2014
  • 资助金额:
    $ 3.25万
  • 项目类别:
Mapping network connectivity within zebrafish segmentation clock and wavefront
映射斑马鱼分段时钟和波前的网络连接
  • 批准号:
    8636711
  • 财政年份:
    2013
  • 资助金额:
    $ 3.25万
  • 项目类别:

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体节形态发生的分子生物物理学和组织生物力学
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  • 财政年份:
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  • 资助金额:
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  • 财政年份:
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  • 财政年份:
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    $ 3.25万
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FEBio - Finite Elements for Biomechanics and Biophysics
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    2008
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