The systems developmental biology of zebrafish body elongation
斑马鱼身体伸长的系统发育生物学
基本信息
- 批准号:10806332
- 负责人:
- 金额:$ 3.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-01-01 至 2027-12-31
- 项目状态:未结题
- 来源:
- 关键词:BiologicalBiomechanicsBiophysicsCell Adhesion MoleculesCellsCellular MorphologyComputer ModelsCongenital AbnormalityData AnalysesDevelopmentDevelopmental BiologyEmbryoEmbryologyEmbryonic DevelopmentGeneticHuman DevelopmentImageMechanicsMethodsModelingMolecularMorphogenesisPatternPattern FormationProtein DynamicsReproducibilityResearchRoleSpinal DysraphismSystemTissuesVertebral columnZebrafishcell behaviorfollow-upin vivoinsightprogramsscoliosissingle molecule
项目摘要
This research program focuses on the systems developmental biology, biophysics and
biomechanics of early spinal column development. The research program utilizes zebrafish as
model for understanding the mechanisms of human development and causes of birth defects
such as scoliosis and spina bifida. The experimental approach is driven by the idea that
quantitative in vivo analysis will lead to fundamental insights into the emergence of biological
organization from the collective interaction of its constituent parts. The research program
combines genetics, embryology, in vivo biophysics, live imaging and systems level data analysis
and computational modeling to study pattern formation and morphogenesis. The proposed
research program will address a number of questions regarding biological order and the
reproducibility of embryonic development. The program will follow-up on the lab’s recent finding
that a dynamically stable pattern of cell state transitions underlies the reproducibility of
development to understand the mechanisms maintaining dynamic stability during zebrafish body
elongation. The research program will also examine the mechanism of mechanical information
regulating the flux of cells through a developmental trajectory. The program will address how
tissue-tissue interactions constrain cell behavior during body elongation. At the molecular and
cellular level, the program will utilize newly developed methods for in vivo single molecule
biophysics to study cell adhesion protein dynamics and their relation to cell state transitions and
cell morphology. Overall, this is multi-scale research program that considers the roles of
molecules, cells and tissues in the genesis of order in the developing embryo.
本研究计划的重点是系统发育生物学,生物物理学和
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('SCOTT A HOLLEY', 18)}}的其他基金
The systems developmental biology of zebrafish body elongation
斑马鱼身体伸长的系统发育生物学
- 批准号:
10552318 - 财政年份:2023
- 资助金额:
$ 3.25万 - 项目类别:
The Molecular Biophysics and Tissue Biomechanics of Somite Morphogenesis
体节形态发生的分子生物物理学和组织生物力学
- 批准号:
9896870 - 财政年份:2018
- 资助金额:
$ 3.25万 - 项目类别:
The cross-scale biomechanics of tissue morphogenesis
组织形态发生的跨尺度生物力学
- 批准号:
9363434 - 财政年份:2017
- 资助金额:
$ 3.25万 - 项目类别:
The cross-scale biomechanics of tissue morphogenesis
组织形态发生的跨尺度生物力学
- 批准号:
9557529 - 财政年份:2017
- 资助金额:
$ 3.25万 - 项目类别:
Quantification of the mechanics of vertebrate body elongation
脊椎动物身体伸长力学的量化
- 批准号:
8837030 - 财政年份:2014
- 资助金额:
$ 3.25万 - 项目类别:
Quantification of the mechanics of vertebrate body elongation
脊椎动物身体伸长力学的量化
- 批准号:
8695630 - 财政年份:2014
- 资助金额:
$ 3.25万 - 项目类别:
Quantification of the mechanics of vertebrate body elongation
脊椎动物身体伸长力学的量化
- 批准号:
9043110 - 财政年份:2014
- 资助金额:
$ 3.25万 - 项目类别:
Quantification and modeling of the emergence of tissue-level mechanics from individual cell heterogeneity
对个体细胞异质性组织水平力学的出现进行量化和建模
- 批准号:
9135441 - 财政年份:2014
- 资助金额:
$ 3.25万 - 项目类别:
Quantification and modeling of the emergence of tissue-level mechanics from individual cell heterogeneity
对个体细胞异质性组织水平力学的出现进行量化和建模
- 批准号:
8934125 - 财政年份:2014
- 资助金额:
$ 3.25万 - 项目类别:
Mapping network connectivity within zebrafish segmentation clock and wavefront
映射斑马鱼分段时钟和波前的网络连接
- 批准号:
8636711 - 财政年份:2013
- 资助金额:
$ 3.25万 - 项目类别:
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