Cancer Systems Biology Scholars Program

描述（由申请人提供）：我们提出的癌症系统生物学学者（CSBS）计划是斯坦福大学的一个博士后培训计划，专注于创新、多学科的癌症研究教育，无缝整合实验和计算生物学，以便系统地揭示癌症的复杂性。该项目旨在培养新一代癌症研究人员，他们接受系统生物学领域的培训，以识别和阐明癌症风险、起始和进展以及治疗反应背后的关键细胞和分子网络。大量且日益普及的技术的迅速出现为人们提供了从事癌症系统生物学研究职业的机会，这些技术提供了全球 DNA、RNA 和蛋白质表达谱。现在可以获得并继续产生大量关于癌症系统的多重、多尺度实验数据，包括细胞系 (CCLE)、小鼠模型和人类疾病 (TCGA)。大多数接受过传统培训的癌症研究人员面临的挑战是如何整合和分析这些复杂的数据集。为了应对这一挑战，显然需要在实验和计算技能方面接受更广泛培训的新一代癌症研究人员，将系统生物学的新兴原理应用于癌症研究。斯坦福大学 CSBS 项目解决了在癌症系统生物学领域开发和实施基于课程的多学科研究教育项目的迫切需要。我们汇集了来自 16 个系/部门的 28 名斯坦福大学导师，在斯坦福大学医学院、工程学院和人文科学学院之间架起桥梁。我们提出了一个为期两年的培训计划，将在四年的培训期内培养 10 名学员，培训将在经过一整年的专门课程开发后开始。总的来说，我们的教师代表了生物科学和计算科学的平等平衡，我们的目标是吸引具有相似背景分布的学员进行共同指导。我们相信，我们项目的创造性火花将来自这些传统上独特的教学学科的整合。我们设想，CSBS 项目的所有毕业生都将获得必要的生物学和计算技能，以便成为癌症系统生物学研究的未来领导者，并产生生物学和临床见解，从而降低癌症的发病率、发病率和死亡率。

DESCRIPTION (provided by applicant): Our proposed Cancer Systems Biology Scholars (CSBS) program is a postdoctoral training program at Stanford University focused on innovative, multidisciplinary cancer research education that seamlessly integrates experimental and computational biology in order to systematically unravel the complexity of cancer. This program aims to produce a new generation of cancer researchers who are trained in the field of systems biology in order to identify and elucidate critical cellular and molecular networks underlying cancer risk, initiation and progression and response to treatment. The opportunity to embark on cancer systems biology research careers has been enabled by the rapid emergence of numerous and increasingly accessible technologies that provide global DNA, RNA and protein expression profiling. A vast amount of multiplexed, multi-scale experimental data is now available and continues to be generated on cancer systems, ranging from cell lines (CCLE), mouse models, and human disease (TCGA). The challenge that most traditionally trained cancer researchers face is how to integrate and analyze this complex datasets. To address this challenge, it is evident that a new generation of cancer researchers with broader training in both experimentation and computation skills is needed to apply the emerging principles of systems biology to the study of cancer. The Stanford CSBS program addresses the pressing need to develop and implement a curriculum-based, multidisciplinary research education program in cancer systems biology. We bring together 28 Stanford faculty mentors from 16 departments/divisions, bridging the Stanford Schools of Medicine, Engineering and Humanities and Sciences. We propose a two-year training program, and will produce 10 trainees over a four year training period, which will begin after one full year of dedicated curriculum development. Collectively, our faculty represent an equal balance of biological and computational science, and our goal is to attract a similar distribution of backgrounds among our trainees for co-mentoring. We believe that the creative spark of our program will emerge from the integration of these traditionally distinctly taught disciplines. We envision that all the graduates of our CSBS Program will have acquired the necessary biological and computational skills in order to become the future leaders of cancer systems biology research and produce biologically and clinically insights that will reduce cancer incidence, morbidity and mortality.