Cancer Systems Biology Scholars Program

癌症系统生物学学者计划

• 批准号: 9120344
• 负责人: SYLVIA KATINA PLEVRITIS
• 金额: $ 53.31万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9120344
• 关键词: Address; Advisory Committees; Biological; Biological Sciences; Cancer Prevention Intervention; Cell Line; Cells; Communication; Complex; Computational Biology; Computational Science; DNA; Data; Data Set; Department chair; Diagnostic; Discipline; Early Diagnosis; Education; Educational Curriculum; Educational process of instructing; Engineering; Ensure; Environment; Equilibrium; Evaluation; Exposure to; Extramural Activities; Face; Faculty; Future; Generations; Genetic; Genetic Transcription; Goals; Grant; Grant Review Process; Health; Humanities; Incidence; Interdisciplinary Study; Knowledge; Letters; Malignant Neoplasms; Mentors; Mentorship; Molecular; Molecular Profiling; Morbidity - disease rate; NCI Scholars Program; Pharmaceutical Preparations; Positioning Attribute; Postdoctoral Fellow; Predisposition; Preparation; Process; Recruitment Activity; Research; Research Personnel; Research Training; Schools; Science; System; Systems Biology; Teacher Professional Development; Technology; Testing; The Cancer Genome Atlas; Therapeutic; Training; Training Programs; Underrepresented Minority; Universities; anticancer research; base; cancer research center director; cancer risk; career; career development; clinically relevant; curriculum development; didactic education; faculty mentor; human disease; improved; innovation; insight; medical schools; meetings; mortality; mouse model; multidisciplinary; post-doctoral training; programs; protein expression; research and development; skills; success; symposium; treatment response

DESCRIPTION (provided by applicant): Our proposed Cancer Systems Biology Scholars (CSBS) program is a postdoctoral training program at Stanford University focused on innovative, multidisciplinary cancer research education that seamlessly integrates experimental and computational biology in order to systematically unravel the complexity of cancer. This program aims to produce a new generation of cancer researchers who are trained in the field of systems biology in order to identify and elucidate critical cellular and molecular networks underlying cancer risk, initiation and progression and response to treatment. The opportunity to embark on cancer systems biology research careers has been enabled by the rapid emergence of numerous and increasingly accessible technologies that provide global DNA, RNA and protein expression profiling. A vast amount of multiplexed, multi-scale experimental data is now available and continues to be generated on cancer systems, ranging from cell lines (CCLE), mouse models, and human disease (TCGA). The challenge that most traditionally trained cancer researchers face is how to integrate and analyze this complex datasets. To address this challenge, it is evident that a new generation of cancer researchers with broader training in both experimentation and computation skills is needed to apply the emerging principles of systems biology to the study of cancer. The Stanford CSBS program addresses the pressing need to develop and implement a curriculum-based, multidisciplinary research education program in cancer systems biology. We bring together 28 Stanford faculty mentors from 16 departments/divisions, bridging the Stanford Schools of Medicine, Engineering and Humanities and Sciences. We propose a two-year training program, and will produce 10 trainees over a four year training period, which will begin after one full year of dedicated curriculum development. Collectively, our faculty represent an equal balance of biological and computational science, and our goal is to attract a similar distribution of backgrounds among our trainees for co-mentoring. We believe that the creative spark of our program will emerge from the integration of these traditionally distinctly taught disciplines. We envision that all the graduates of our CSBS Program will have acquired the necessary biological and computational skills in order to become the future leaders of cancer systems biology research and produce biologically and clinically insights that will reduce cancer incidence, morbidity and mortality.

描述（由申请人提供）：我们提议的癌症系统生物学学者（CSBS）计划是斯坦福大学的博士后培训计划，专注于创新，多学科癌症研究教育，无缝集成实验和计算生物学，以系统地揭示癌症的复杂性。该计划旨在培养新一代癌症研究人员，他们在系统生物学领域接受过培训，以识别和阐明癌症风险，启动和进展以及对治疗反应的关键细胞和分子网络。开展癌症系统生物学研究事业的机会是由众多且越来越容易获得的技术的快速出现所实现的，这些技术提供了全球DNA，RNA和蛋白质表达谱。大量的多重，多尺度的实验数据现在是可用的，并继续在癌症系统中产生，从细胞系（CCLE），小鼠模型和人类疾病（TCGA）。大多数受过传统训练的癌症研究人员面临的挑战是如何整合和分析这些复杂的数据集。为了应对这一挑战，很明显，需要新一代的癌症研究人员在实验和计算技能方面接受更广泛的培训，以将系统生物学的新兴原理应用于癌症研究。该斯坦福大学CSBS计划解决了迫切需要开发和实施一个以癌症系统生物学为基础的多学科研究教育计划。我们汇集了来自16个系/部门的28位斯坦福大学教师导师，为斯坦福大学医学院、工程学院和人文科学学院架起了桥梁。我们提出了一个为期两年的培训计划，并将在四年的培训期内培养10名学员，培训期将在一整年的专门课程开发后开始。总的来说，我们的教师代表了生物科学和计算科学的平等平衡，我们的目标是吸引我们的学员共同指导的背景类似的分布。我们相信，我们的计划的创意火花将从这些传统的独特的教学学科的整合出现。我们设想，我们的CSBS计划的所有毕业生都将获得必要的生物和计算技能，以成为癌症系统生物学研究的未来领导者，并产生生物学和临床见解，这将降低癌症的发病率，发病率和死亡率。