Cancer Systems Biology Scholars Program

描述(由申请人提供)：我们建议的癌症系统生物学学者(CSBS)项目是斯坦福大学的博士后培训项目，专注于创新的、多学科的癌症研究教育，无缝地整合实验生物学和计算生物学，以便系统地揭示癌症的复杂性。该项目旨在培养在系统生物学领域接受培训的新一代癌症研究人员，以识别和阐明潜在的癌症风险、发生和发展以及对治疗的反应的关键细胞和分子网络。提供全球DNA、RNA和蛋白质表达图谱的众多和日益普及的技术的迅速出现，使从事癌症系统生物学研究事业的机会成为可能。从细胞系(CCLE)、小鼠模型到人类疾病(TCGA)，大量多路、多尺度的实验数据现已可用，并将继续在癌症系统中产生。大多数受过传统训练的癌症研究人员面临的挑战是如何整合和分析这些复杂的数据集。为了应对这一挑战，显然需要在实验和计算技能方面接受更广泛培训的新一代癌症研究人员，将系统生物学的新兴原理应用于癌症研究。斯坦福大学的CSBS项目解决了开发和实施基于课程的、多学科的癌症系统生物学研究教育项目的迫切需要。我们汇集了来自16个系/部门的28名斯坦福大学教师导师，为斯坦福大学医学院、工程学院和人文与科学学院架起了桥梁。我们提出了一个为期两年的培训计划，并将在四年的培训期间内培养10名学员，培训将在专门课程开发一整年后开始。总体而言，我们的教师代表着生物科学和计算科学的平等平衡，我们的目标是吸引类似背景分布的受训者共同指导。我们相信，我们项目的创造性火花将来自于这些传统上明确教授的学科的整合。我们预计，我们CSBS项目的所有毕业生都将获得必要的生物学和计算技能，以便成为未来癌症系统生物学研究的领导者，并产生将降低癌症发病率、发病率和死亡率的生物学和临床见解。

DESCRIPTION (provided by applicant): Our proposed Cancer Systems Biology Scholars (CSBS) program is a postdoctoral training program at Stanford University focused on innovative, multidisciplinary cancer research education that seamlessly integrates experimental and computational biology in order to systematically unravel the complexity of cancer. This program aims to produce a new generation of cancer researchers who are trained in the field of systems biology in order to identify and elucidate critical cellular and molecular networks underlying cancer risk, initiation and progression and response to treatment. The opportunity to embark on cancer systems biology research careers has been enabled by the rapid emergence of numerous and increasingly accessible technologies that provide global DNA, RNA and protein expression profiling. A vast amount of multiplexed, multi-scale experimental data is now available and continues to be generated on cancer systems, ranging from cell lines (CCLE), mouse models, and human disease (TCGA). The challenge that most traditionally trained cancer researchers face is how to integrate and analyze this complex datasets. To address this challenge, it is evident that a new generation of cancer researchers with broader training in both experimentation and computation skills is needed to apply the emerging principles of systems biology to the study of cancer. The Stanford CSBS program addresses the pressing need to develop and implement a curriculum-based, multidisciplinary research education program in cancer systems biology. We bring together 28 Stanford faculty mentors from 16 departments/divisions, bridging the Stanford Schools of Medicine, Engineering and Humanities and Sciences. We propose a two-year training program, and will produce 10 trainees over a four year training period, which will begin after one full year of dedicated curriculum development. Collectively, our faculty represent an equal balance of biological and computational science, and our goal is to attract a similar distribution of backgrounds among our trainees for co-mentoring. We believe that the creative spark of our program will emerge from the integration of these traditionally distinctly taught disciplines. We envision that all the graduates of our CSBS Program will have acquired the necessary biological and computational skills in order to become the future leaders of cancer systems biology research and produce biologically and clinically insights that will reduce cancer incidence, morbidity and mortality.