South Carolina Collaborative Alliance for Stroke Trials (SC-CoAST)

南卡罗来纳州卒中试验合作联盟 (SC-CoAST)

• 批准号: 9119885
• 负责人: Edward C Jauch
• 金额: $ 33.18万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-25 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9119885
• 关键词: Academic Medical Centers; Acute; Address; Adult; African American; Ally; Caring; Cause of Death; Childhood stroke; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Communities; Community Hospitals; Contracts; Country; Development; Discipline; Disease; Drops; Education; Ensure; Environment; Epidemic; Etiology; Evaluation; Fibrinolysis; Goals; Health; Health Hazards; Health Personnel; Health Services Accessibility; Health system; Healthcare; Healthcare Systems; Heart; Image; Incidence; Individual; Interdisciplinary Study; Intervention; Intervention Studies; Ischemic Stroke; Leadership; Medical; Mentors; Mission; Multicenter Trials; National Institute of Neurological Disorders and Stroke; Neurosciences; Patients; Perception; Population; Population Heterogeneity; Positioning Attribute; Prevention; Recovery; Recruitment Activity; Rehabilitation therapy; Reperfusion Therapy; Research; Research Infrastructure; Research Personnel; Running; Rural; Science; Scientist; Secondary Prevention; South Carolina; Staging; Stroke; System; Techniques; Therapeutic; Thinking; Time; Training; United States; Universities; Work; acute stroke; base; bioimaging; care systems; career; career development; clinical care; clinical infrastructure; data management; experience; health care availability; high risk; imaging biomarker; improved; innovation; member; mortality; new technology; next generation; novel; novel therapeutics; outreach; preclinical trial; rehabilitation strategy; response; socioeconomics; stroke education; stroke intervention; stroke recovery; stroke therapy; stroke treatment; tertiary care; trial design

DESCRIPTION (provided by applicant): Despite dropping to the fourth leading cause of death in the United States, the incidence of stroke continues to rise and the individual and societal impact continues to grow. The burden of stroke disproportionately impacts lower socioeconomic populations and is particularly concentrated in the Southeast United States - the so-called Stroke Belt. Reaching these populations for stroke education, prevention, acute treatment, rehabilitation, and in particular in engagement in clinical research, remains a challenge. Developing clinical and research infrastructures to engage these populations are critical to change the disproportionate stroke burden. The perception of stroke as a treatable disease and the systems of care developed to manage stroke have made major advances from a time when stroke was viewed nihilistically. The development of fibrinolysis for stroke dramatically changed the paradigm for acute stroke treatment - for the first time acute ischemic stroke could be "reversed". This development provided promise and enthusiasm for developing further preventative, acute interventions, and novel rehabilitation strategies, but to date, clinical trial of potential therapies have yet to produce a definitive new reperfusion strategy. Conducting multicenter clinical trials of stroke therapies and interventions often must be performed within a highly contracted time scale, requiring innovative thinking and redesign of many aspects of the science of clinical trials. To be effective and fast, the NINDS Stroke Trials Network will require spectrum of clinicians, researchers, and allied healthcare providers to create a regional infrastructure that will effectively and efficiently recruit patients into trials across the broad spectrum of stroke etiologies and time frames. In this application the investigators propose to become a Regional Coordinating Center (RCC) in the NINDS Stroke Trials Network (RFA-NS-13-011). The South Carolina Collaborative Alliance for Stroke Irials (SC-CoAST) Network is a unique collaboration between 3 academic medical centers, the Medical University of South Carolina, the University of South Carolina, and the Greenville Heath System, situated in the heart of the Stroke Belt. The overall goals of the SC-CoAST Network are: 1) to expand the SC state-wide stroke organization to improve stroke care and research; 2) to leverage the SC-CoAST collaboration to become a leading center within the STN; 3) to utilize SC-CoAST preclinical researchers in developing potential interventions for study within the STN; and 4) to engage SC-CoAST senior leaders in identifying, mentoring, and training young clinician-scientists at this formative stage of their career development.

描述（由申请人提供）：尽管下降到美国第四大死亡原因，但中风的发病率仍在上升，个人和社会影响不断增长。中风的负担不成比例地影响较低的社会经济人口，尤其集中在美国东南部 - 所谓的中风带。吸引这些人群进行中风教育，预防，急性治疗，康复，尤其是从事临床研究的参与，仍然是一个挑战。开发临床和研究基础设施来吸引这些人群对于改变不成比例的中风负担至关重要。 从看不见中风的时候，人们对中风作为一种可治疗疾病以及为管理中风而开发的护理体系的看法取得了重大进步。中风的纤维蛋白溶解的发展急剧改变了急性中风治疗的范式 - 首次可以“逆转”急性缺血性中风。这种发展为发展进一步的预防，急性干预和新颖的康复策略提供了希望和热情，但是迄今为止，潜在疗法的临床试验尚未产生确定的新再灌注策略。进行中风疗法和干预措施的多中心临床试验通常必须在高度合同的时间范围内进行，需要创新的思维和重新设计临床试验科学的许多方面。为了有效而迅速，NINDS中风试验网络将需要大量临床医生，研究人员和相关医疗保健提供者来创建区域基础设施，该区域基础设施将有效，有效地将患者招募到各种中风病因和时间范围的试验中。 在此应用程序中，研究人员建议在NINDS中风试验网络（RFA-NS-13-011）中成为区域协调中心（RCC）。南卡罗来纳州中风伊利亚斯（SC-COAST）网络的南卡罗来纳州合作联盟是一个独特的合作，位于卒中腰带中心的3个学术医学中心，南卡罗来纳大学，南卡罗来纳大学和格林维尔·希思系统之间。 SC海岸网络的总体目标是：1）扩大SC范围的中风组织以改善中风护理和研究； 2）利用SC Coast合作成为STN中的领先中心； 3）利用SC海岸临床前研究人员在STN内开发潜在的研究干预措施； 4）与SC Coast高级领导人一起在职业发展的这个成长阶段识别，指导和培训年轻的临床医生。