PARACAS: Program for Advanced Research Capacities for AIDS in Peru

描述（由申请人提供）：秘鲁艾滋病高级研究能力计划（PARACAS）的总体目标是在秘鲁卡耶塔诺埃雷迪亚大学（UPCH）巩固一个成熟的艾滋病毒研究培训框架，其中杰出的年轻或职业中期健康研究人员将通过提供可靠的证据来实施优化和高效的护理模式，从而全面解决艾滋病毒是一种慢性、长期疾病的事实，从而实现科学自主权。不可否认，卫生服务应促进尽早开始抗逆转录病毒治疗（ART），同时增加对艾滋病毒/艾滋病患者（PLWHA）的护理，因为这种结合可以维护并有益于个人和社区的健康。在这方面，PARACAS 的学员将提出基于综合分析的干预策略，该分析考虑与进入和保留护理过程相关的生物医学方面和多维视角，例如 PLWHA（成人、青少年和儿童）及其家庭、社区和卫生人员的视角。因此，拟议的美国相关培训（3 个 MPH 培训生和 2 个博士后职位）将基于两个支柱：行为科学，对这些观点进行广泛、科学的分析；和实施科学，以确保分析可以转化为具体的基于证据的干预措施。由于秘鲁常见的结核病 (TB)，特别是耐多药结核病，增加了感染者的疾病负担，我们的 PARACAS 还将解决这些感染作为早期进入和保留护理的障碍的作用。 PARACAS 是继秘鲁卡耶塔诺埃雷迪亚大学 (UPCH)、西雅图华盛顿大学 (UW) 和阿拉巴马大学伯明翰分校 (UAB) 等三所大学成功合作之后推出的一项举措，因此还设想了长期的学术成果。 PARACAS 将通过培养“批判性超前思考”模式，激发具有互补专业知识和不同经验水平的学员，甚至高级本科医学生（串联研究小组）的互动、领导力和团队合作，实现指导系统并促进“变革性学习”。这些策略应有助于培养新一代的医学科学家，他们的贡献应继续改善艾滋病毒感染者的生活。

DESCRIPTION (provided by applicant): The overall aim of our Program for Advanced ReseArch Capacities for AIDS in Peru (PARACAS) is to consolidate a mature HIV research training framework at Universidad Peruana Cayetano Heredia (UPCH), in which outstanding young or mid-career health researchers will reach scientific autonomy by providing sound evidence for the implementation of optimized and efficient care models that comprehensibly address the fact that HIV is rather a chronic, prolonged condition. Undeniably, health services should foster earlier initiation of antiretroviral therapy (ART) in parallel to increasing retentio in care of people living with HIV/AIDS (PLWHA), as this combination preserves and benefits individual and community health. In that regard, PARACAS' trainees will propose intervention strategies built upon a comprehensive analysis that considers biomedical aspects and multidimensional perspectives related with the processes of entry and retention in care, such as the perspectives of PLWHA (adult, adolescents, and children), of their families, their communities, and the health staff. Accordingly, the proposed interrelated training at US (3 MPH trainees and 2 postdoctoral positions) will be based on two pillars: behavioral sciences for a broad, scientific analysis of those perspectives; and implementation science, to assure that the analysis can be translated to specific evidence-based interventions. Because coexistent tuberculosis (TB) and particularly multidrug resistant TB, frequent in Peru, add burden of disease to PLWHA, our PARACAS will also address the role of these infections as barriers for early entry and retention in care. As PARACAS stands as an initiative that follows the successful collaboration of three universities, Universidad Peruana Cayetano Heredia (UPCH), the University of Washington (UW) in Seattle, and the University of Alabama at Birmingham (UAB), long-standing academic outputs are also envisioned. PARACAS will enable mentoring systems and promote "transformative learning" by means of fostering the "thinking critically ahead" model and stimulating the interaction, leadership, and team work of trainees with complementary expertise and different level of experience, even advanced undergraduate medical students (tandem research groups). These strategies should serve to nurture new incoming generations of physician scientists whose contributions should continue notoriously improving the lives of PLWHA.