PARACAS: Program for Advanced Research Capacities for AIDS in Peru

描述（申请人提供）：我们在秘鲁的艾滋病高级研究能力方案（帕拉卡斯）的总体目标是巩固秘鲁卡耶塔诺埃雷迪亚大学（UPCH）成熟的艾滋病毒研究培训框架，其中，年轻人或年轻人，职业健康研究人员将通过为实施优化和有效的护理模式提供可靠的证据来实现科学自主权，这些模式可以全面地解决艾滋病毒是一种长期的慢性病不可否认，保健服务应促进尽早开始抗逆转录病毒疗法，同时增加对艾滋病毒/艾滋病感染者的护理，因为这种结合可维护和有益于个人和社区的健康。在这方面，该帕拉卡斯的学员将在综合分析的基础上提出干预战略，该分析考虑到了与进入和继续接受护理过程有关的生物医学方面和多层面观点，例如艾滋病毒/艾滋病感染者（成人、青少年和儿童）、其家庭、其社区和卫生工作人员的观点。因此，在美国拟议的相互关联的培训（3名MPH学员和2个博士后职位）将基于两个支柱：行为科学，对这些观点进行广泛的科学分析;和实施科学，以确保分析可以转化为具体的循证干预措施。由于结核病，特别是耐多药结核病在秘鲁很常见，同时存在，增加了艾滋病毒/艾滋病感染者的疾病负担，我们帕拉卡斯还将处理这些感染作为早期接受和继续接受护理的障碍所起的作用。由于帕拉卡斯是继秘鲁卡耶塔诺埃雷迪亚大学（UPCH）、西雅图的华盛顿大学（UW）和伯明翰的亚拉巴马大学（UAB）三所大学成功合作之后的一项倡议，还设想了长期的学术成果。帕拉卡斯将通过培养“批判性地超前思考”模式，激励具有互补专业知识和不同经验水平的学员，甚至是高等本科医学生的互动、领导和团队合作，实现辅导系统，促进“变革性学习”（串联研究小组）。这些战略应有助于培养新一代的医生科学家，他们的贡献应继续众所周知地改善艾滋病毒/艾滋病感染者的生活。

DESCRIPTION (provided by applicant): The overall aim of our Program for Advanced ReseArch Capacities for AIDS in Peru (PARACAS) is to consolidate a mature HIV research training framework at Universidad Peruana Cayetano Heredia (UPCH), in which outstanding young or mid-career health researchers will reach scientific autonomy by providing sound evidence for the implementation of optimized and efficient care models that comprehensibly address the fact that HIV is rather a chronic, prolonged condition. Undeniably, health services should foster earlier initiation of antiretroviral therapy (ART) in parallel to increasing retentio in care of people living with HIV/AIDS (PLWHA), as this combination preserves and benefits individual and community health. In that regard, PARACAS' trainees will propose intervention strategies built upon a comprehensive analysis that considers biomedical aspects and multidimensional perspectives related with the processes of entry and retention in care, such as the perspectives of PLWHA (adult, adolescents, and children), of their families, their communities, and the health staff. Accordingly, the proposed interrelated training at US (3 MPH trainees and 2 postdoctoral positions) will be based on two pillars: behavioral sciences for a broad, scientific analysis of those perspectives; and implementation science, to assure that the analysis can be translated to specific evidence-based interventions. Because coexistent tuberculosis (TB) and particularly multidrug resistant TB, frequent in Peru, add burden of disease to PLWHA, our PARACAS will also address the role of these infections as barriers for early entry and retention in care. As PARACAS stands as an initiative that follows the successful collaboration of three universities, Universidad Peruana Cayetano Heredia (UPCH), the University of Washington (UW) in Seattle, and the University of Alabama at Birmingham (UAB), long-standing academic outputs are also envisioned. PARACAS will enable mentoring systems and promote "transformative learning" by means of fostering the "thinking critically ahead" model and stimulating the interaction, leadership, and team work of trainees with complementary expertise and different level of experience, even advanced undergraduate medical students (tandem research groups). These strategies should serve to nurture new incoming generations of physician scientists whose contributions should continue notoriously improving the lives of PLWHA.