UAB Vision Science Research Center

UAB视觉科学研究中心-整体核心 7.项目概要/摘要 1979年，NEI核心补助金首次授予UAB。在接下来的35年里，该机构继续 对增长的承诺导致了视觉研究的显着扩展。参与者现在增加了 从两个省的13人增加到五个省的23人， 校外资助核心参与者中有11人目前持有14个合格赠款，另外7人拥有NEI新 调查员身份，并正在寻求NEI R 01支持（其中四人已提交NEI R 01）。的 纳入5名参与者，其中2名为合作研究者，3名已提交NEI R 01 R01每年，NEI的资金超过300万美元，不包括内部UAB奖励。每年校外共计 UAB与视觉相关的研究资金已增长到近1300万美元。的一个主要研究重点 参与者是视觉神经科学，16积极参与解剖，生物化学，生理学，或 视网膜和中央视觉通路的心理物理学研究。此外，UAB视觉研究小组 专注于青光眼、AMD、近视、圆锥角膜、干眼和白内障的研究。本申请 请求提供资金，继续提供服务和设施，以支持参与者的研究活动 通过四个专业的核心这些核心提供最先进的设施和专业知识， 专门为每种用途设计的专用空间。仪器核心由一名 设计和制造复杂的新型电子设备的电子工程师和机械师/工具专家 以及设计和制造独特机械装置的模具制造商。两者还修复和维持电流 大大降低了维修成本。研究编程与计算分析核心 提供高端分析工具，并配备一名经验丰富的程序员/分析师， 在计算机科学领域，提供定制软件开发和软件/硬件接口， 兼职经验丰富的生物统计学家，将协助实验设计和统计分析。的 分子和细胞分析中心的工作人员是一名医学博士/博士培训的科学家，他为以下方面提供专业知识： 研究设计、培训和获得DNA、RNA和蛋白质研究和形态学的主要仪器 组织和细胞的分析。新的眼表型核心将由一名博士兼职工作， 几年的专业知识，在使用所有仪器的结构和功能的分析小 人类眼病的动物模型。自1979年以来，已提供了超过1700万美元的机构援助， 迄今为止，支持视觉研究，并在未来5年内承诺提供80多万美元， NIH支持。UAB视觉科学正处于一个令人兴奋的增长阶段，专注于使用先进的 技术和招聘最好的科学家来研究和设计眼部疾病的治疗方法。的 继续P30视觉研究核心补助金是新发现的核心要素， 在UAB的视觉科学

UAB Vision Science Research Center - Overall Core 7. Project Summary/Abstract In 1979, an NEI Core grant was first awarded to UAB. Over the next 35 years, the institution's continued commitment to growth resulted in a remarkable expansion in vision research. Participants have now increased from 13 in two departments to 23 in five departments, and there has been a concomitant increase in extramural funding. Eleven of the Core participants currently hold 14 eligble grants, another 7 have NEI new investigator status and are seeking NEI R01 support (four of these have submitted NEI R01s). Of the reminaing five participants, two are Co-Investigators an an active NEI R01 and three have submitted NEI R01s. Annually, NEI funding exceeds $3M million, not including internal UAB awards. Total annual extramural funding for vision-related research at UAB has grown to nearly $13 million. A major research focus of the participants is visual neuroscience, with 16 actively involved in anatomical, biochemical, physiological, or psychophysical studies of the retina and central visual pathways. Additionally, UAB vision research groups are focused on the study of glaucoma, AMD, myopia, keratoconus, dry eye and cataractogenesis. This application requests funds to continue to provide services and facilities to support the research activity of the participants through four professionally staffed cores. These cores provide state-of-the-art facilities and expertise in dedicated spaces designed specifically for each purpose. The Instrumentation Core is staffed by an electronics engineer who designs and builds complex novel electronic apparati and an expert machinist/tool and die maker who designs and fabricates unique mechanical devices. Both also repair and maintain current instruments greatly reducing repair costs. The Research Programming & Computational Analysis Core provides access to high-end analytical tools and is staffed by an experienced programmer/analyst with an MS in computer sciences who offers custom software development and software/hardware interfacing, and by a part-time experienced biostatistician who will assist in experimental design and statistical analysis. The Molecular & Cellular Analysis Core is staffed by an MD/PhD trained scientist who provides expertise for study design, training and access to major instrumentation for DNA, RNA and protein studies and morphologic analysis of tissues and cells. The new Ocular Phenotyping Core will be part-time staffed by a PhD who has several years of expertise in the use of all instrumentation for analysis of the structure and function of small animal models of human ocular disease. Since 1979, more than $17M has been provided in institutional support of vision research to date and more than $800,000 is committed over the next 5 years of requested NIH support. UAB vision science is in an exciting growth phase that is focused on the use of advanced technology and the recruitment of the best scientists to study and devise treatments for ocular disorders. The continuation of the P30 core grant for vision research is an essential element at the core of new discovery in vision science at UAB.