UAB Core Grant for Vision Research

UAB视力研究中心-整体核心 项目摘要/摘要 1979年，NEI核心奖助金首次授予UAB。在接下来的41年里，该机构致力于 战略增长导致视觉研究的显著扩展。参与者从2人中的13人增加到 各部门增加到3个部门的25个，同时也增加了外部资金。20人参加 目前持有24项符合NEI R01标准的资助金。一名参与者提交了R01申请，并收到了 非常好的分数。三名参与者拥有NEI新的调查员身份。它们要么在K-上，要么刚刚完成- 并将在此续期期间提交NEI R01申请。每年，NEI基金超过 1,260万美元，不包括UAB内部奖励。UAB为视觉相关研究提供的外部资金 增长到每年近1610万美元。UAB视觉科学家研究视觉神经科学(解剖学、生物学- 视网膜、青光眼和中央视觉通路的化学、生理或心理物理研究)，AMD， 近视、圆锥角膜、干眼和白内障等。Brian Samuels博士，博士是主任 在P30中，现在命名为UAB视觉研究中心核心(CCVR)，以及管理核心， 并将对所有支出和核心的正常运作负主要责任。他会协调 与UAB机构支持的视觉科学研究中心主任Steve Pittler博士 (VSRC)和CCVR联席主任，以确保核心资源和服务与参与者的需求保持一致。 这项申请申请的资金，以提供持续支持参与者的研究活动通过四个 配备专业人员的核心。每个核心，位于沃尔克大厅的中央，提供最先进的设施和 专门针对每个目的的专业知识。由Paul Gamiln博士执导的Machine Shop Core设计和 制造独特的机械设备并维修/维护现有仪器。研究报告 编程与计算分析核心，由J.Crawford Down博士指导，提供访问 高端分析工具，包括高级图像和大数据分析、计算机编程、定制 软件/硬件开发和接口，以及数据库开发/管理。分子与 细胞分析核心由史蒂夫·皮特勒博士领导，为分子和细胞研究提供专业知识 设计、培训和使用DNA、RNA和蛋白质研究以及形态研究的主要仪器 组织和细胞的分析。由蒂莫西·克拉夫特博士执导的视觉表型核心提供了 协助分析人眼小动物模型结构和功能的资源和服务 疾病与研究设计和生物统计分析。自1979年以来，视觉研究已经收到了超过 在未来5年的资金周期中，承诺提供1900万美元的机构支持和100多万美元。UAB有 通过专注于先进技术的使用，成长为视觉研究的全国领先者 招募最好的科学家来研究和设计治疗眼病的方法。P30的延续 视觉研究的核心拨款是UAB视觉科学新发现的核心要素。

UAB Center for Vision Research - Overall Core Project Summary/Abstract In 1979, an NEI Core grant was first awarded to UAB. Over the next 41 years, the institution's commitment to strategic growth resulted in significant expansion of vision research. Participants have increased from 13 in 2 departments to 25 in 3 departments, with a concominant increase in extramural funding. Twenty participants currently hold 24 eligble NEI R01 grants. One participant has submitted an R01 application and received an exceptional score. Three participants have NEI new investigator status. They are either on or just completed K- awards and will be submitting NEI R01 applications during this renewal period. Annually, NEI funds exceed $12.6 million, not including internal UAB awards. Extramural funding for vision-related research at UAB has grown to nearly $16.1 million annually. UAB vision scientists study visual neuroscience (anatomical, bio- chemical, physiological, or psychophysical studies of the retina, glaucoma, and central visual pathways), AMD, myopia, keratoconus, dry eye and cataractogenesis among others. Dr. Brian Samuels MD, PhD is the Director of the P30, now named the UAB Center Cores for Vision Research (CCVR), and the Administrative Core, and will have primary responsibility for all expenditures and proper functioning of the cores. He will coordinate with Dr. Steve Pittler, PhD, Director of the UAB institutionally supported Vision Science Research Center (VSRC) and co-director of the CCVR, to ensure the core resources and services align with participant needs. This application requests funds to provide continued support participants’ research activities through four professionally staffed cores. Each core, centrally located in Volker Hall, provides state-of-the-art facilities and expertise specifically for each purpose. The Machine Shop Core, directed by Paul Gamiln, PhD., designs and fabricates unique mechanical devices and repair/maintenance of current instruments. The Research Programming & Computational Analysis Core, directed by J. Crawford Downs, PhD, provides access to high-end analytical tools including advanced image and big-data analysis, computer programming, custom software/hardware development and interfacing, and database development/management. The Molecular & Cellular Analysis Core, directed by Steve Pittler, PhD., provides expertise for molecular and cellular study designs, training and access to major instrumentation for DNA, RNA and protein studies and morphologic analysis of tissues and cells. The Ocular Phenotyping Core, directed by Timothy Kraft, PhD, provides resources and services to assist with structural and functional analysis of small animal models of human ocular disease and study design and biostatistical analysis. Since 1979, vision research has received more than $19M in institutional support and more than $1M is committed over the next 5 years funding cycle. UAB has grown into a national leader in vision research by focusing on the use of advanced technology and the recruiting the best scientists to study and devise treatments for ocular disorders. The continuation of the P30 core grant for vision research is an essential element at the core of new discovery in vision science at UAB.