UAB Core Grant for Vision Research

UAB 视觉研究核心资助

• 批准号: 10681446
• 负责人: Brian Christopher Samuels
• 金额: $ 74.06万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10681446
• 关键词: Affect; Age related macular degeneration; American; Anatomy; Animal Model; Area; Award; Benchmarking; Big Data; Biochemical; Biometry; Caliber; Cataract; Cells; Collaborations; Complement; Computer Analysis; Computer software; Computers and Advanced Instrumentation; Consensus; Core Facility; Core Grant; Custom; DNA; Data Analyses; Database Management Systems; Databases; Development; Diagnostic; Disease; Doctor of Philosophy; Elements; Ensure; Equipment; Expenditure; Experimental Designs; Extramural Activities; Eye diseases; Faculty; First Independent Research Support and Transition Awards; Funding; Glaucoma; Goals; Grant; Growth; Hour; Image; Image Analysis; Individual; Institution; K-Series Research Career Programs; Keratoconus; Maintenance; Modality; Molecular; Monitor; Morphology; Myopia; Names; Outcome; Participant; Phenotype; Physiological; Productivity; Proteins; Psychophysics; Publications; Quality of life; RNA; Request for Applications; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Retina; Retinitis Pigmentosa; Scientific Inquiry; Scientist; Services; Structure; Surveys; Technology; Time; Tissues; Training; United States National Institutes of Health; Vision; Vision Disorders; Vision research; Visual Pathways; analytical tool; career; computer program; design; experimental analysis; eye dryness; human model; improved; innovation; instrument; instrumentation; mechanical device; meetings; novel; programs; recruit; repaired; satisfaction; skills; success; synergism; vision science; visual neuroscience

UAB Center for Vision Research - Overall Core Project Summary/Abstract In 1979, an NEI Core grant was first awarded to UAB. Over the next 41 years, the institution's commitment to strategic growth resulted in significant expansion of vision research. Participants have increased from 13 in 2 departments to 25 in 3 departments, with a concominant increase in extramural funding. Twenty participants currently hold 24 eligble NEI R01 grants. One participant has submitted an R01 application and received an exceptional score. Three participants have NEI new investigator status. They are either on or just completed K- awards and will be submitting NEI R01 applications during this renewal period. Annually, NEI funds exceed $12.6 million, not including internal UAB awards. Extramural funding for vision-related research at UAB has grown to nearly $16.1 million annually. UAB vision scientists study visual neuroscience (anatomical, bio- chemical, physiological, or psychophysical studies of the retina, glaucoma, and central visual pathways), AMD, myopia, keratoconus, dry eye and cataractogenesis among others. Dr. Brian Samuels MD, PhD is the Director of the P30, now named the UAB Center Cores for Vision Research (CCVR), and the Administrative Core, and will have primary responsibility for all expenditures and proper functioning of the cores. He will coordinate with Dr. Steve Pittler, PhD, Director of the UAB institutionally supported Vision Science Research Center (VSRC) and co-director of the CCVR, to ensure the core resources and services align with participant needs. This application requests funds to provide continued support participants’ research activities through four professionally staffed cores. Each core, centrally located in Volker Hall, provides state-of-the-art facilities and expertise specifically for each purpose. The Machine Shop Core, directed by Paul Gamiln, PhD., designs and fabricates unique mechanical devices and repair/maintenance of current instruments. The Research Programming & Computational Analysis Core, directed by J. Crawford Downs, PhD, provides access to high-end analytical tools including advanced image and big-data analysis, computer programming, custom software/hardware development and interfacing, and database development/management. The Molecular & Cellular Analysis Core, directed by Steve Pittler, PhD., provides expertise for molecular and cellular study designs, training and access to major instrumentation for DNA, RNA and protein studies and morphologic analysis of tissues and cells. The Ocular Phenotyping Core, directed by Timothy Kraft, PhD, provides resources and services to assist with structural and functional analysis of small animal models of human ocular disease and study design and biostatistical analysis. Since 1979, vision research has received more than $19M in institutional support and more than $1M is committed over the next 5 years funding cycle. UAB has grown into a national leader in vision research by focusing on the use of advanced technology and the recruiting the best scientists to study and devise treatments for ocular disorders. The continuation of the P30 core grant for vision research is an essential element at the core of new discovery in vision science at UAB.

UAB 视觉研究中心 - 整体核心 项目概要/摘要 1979 年，UAB 首次获得 NEI 核心资助。在接下来的 41 年里，该机构致力于 战略增长导致视觉研究的显着扩展。参与者从 13 人增加到 2 人 院系增至3个院系25个，校外经费也随之增加。二十名参加者 目前持有 24 项符合资格的 NEI R01 补助金。一名参与者已提交 R01 申请并收到 优异的成绩。三名参与者拥有 NEI 新研究者身份。他们要么正在完成K-，要么刚刚完成K- 授予，并将在此续订期间提交 NEI R01 申请。每年，NEI 资金超过 1260 万美元，不包括 UAB 内部奖励。阿拉巴马大学视觉相关研究的校外资助 每年增长至近 1610 万美元。 UAB 视觉科学家研究视觉神经科学（解剖学、生物 视网膜、青光眼和中央视觉通路的化学、生理或心理物理学研究）、AMD、 近视、圆锥角膜、干眼症和白内障等。 Brian Samuels 医学博士、哲学博士是主任 P30 的一部分，现命名为 UAB 视觉研究中心核心 (CCVR) 和管理核心， 将对核心的所有支出和正常运作承担主要责任。他会协调 与 UAB 机构支持的视觉科学研究中心主任 Steve Pittler 博士合影 (VSRC) 和 CCVR 联合主任，以确保核心资源和服务符合参与者的需求。 该申请要求资金通过四个方面持续支持参与者的研究活动 拥有专业的核心人员。每个核心都位于沃尔克大厅的中心，提供最先进的设施和 专门针对每个目的的专业知识。由 Paul Gamiln 博士指导的 Machine Shop Core 设计并 制造独特的机械装置并修理/维护现有仪器。研究 编程和计算分析核心，由 J. Crawford Downs 博士指导，提供访问 高端分析工具，包括高级图像和大数据分析、计算机编程、定制 软件/硬件开发和接口，以及数据库开发/管理。分子与 由 Steve Pittler 博士指导的细胞分析核心为分子和细胞研究提供专业知识 设计、培训和使用用于 DNA、RNA 和蛋白质研究以及形态学的主要仪器 组织和细胞分析。由 Timothy Kraft 博士指导的眼部表型核心提供 协助对人眼小动物模型进行结构和功能分析的资源和服务 疾病和研究设计以及生物统计分析。自 1979 年以来，视觉研究已获得超过 1900 万美元的机构支持以及未来 5 年融资周期内承诺的超过 100 万美元。阿拉巴马大学有 通过专注于先进技术和应用的运用，成长为视觉研究领域的全国领先者 招募最优秀的科学家来研究和设计眼部疾病的治疗方法。 P30的延续 视觉研究的核心资助是阿拉巴马大学视觉科学新发现的核心要素。

项目成果

A Novel Organ Culture Model to Quantify Collagen Remodeling in Tree Shrew Sclera.

• DOI: 10.1371/journal.pone.0166644
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Baldivia S;Levy A;Hegde S;Aper SJ;Merkx M;Grytz R
• 通讯作者: Grytz R

Autofluorescent Organelles Within the Retinal Pigment Epithelium in Human Donor Eyes With and Without Age-Related Macular Degeneration.

• DOI: 10.1167/iovs.63.1.23
• 发表时间: 2022-01-03
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Bermond K;von der Emde L;Tarau IS;Bourauel L;Heintzmann R;Holz FG;Curcio CA;Sloan KR;Ach T
• 通讯作者: Ach T

Glaucomatous Visual Field Progression in the African Descent and Glaucoma Evaluation Study (ADAGES): Eleven Years of Follow-up.

• DOI: 10.1016/j.ajo.2022.02.003
• 发表时间: 2022-07
• 期刊: AMERICAN JOURNAL OF OPHTHALMOLOGY
• 影响因子: 4.2
• 作者: Melchior, Bruna;Valenzuela, Ives A.;de Moraes, C. Gustavo;Paula, Jayter S.;Fazio, Massimo A.;Girkin, Christopher A.;Proudfoot, James;Cioffi, George A.;Weinreb, Robert N.;Zangwill, Linda M.;Liebmann, Jeffrey M.
• 通讯作者: Liebmann, Jeffrey M.

What Do Animal Studies Tell Us about the Mechanism of Myopia-Protection by Light?

• DOI: 10.1097/opx.0000000000000917
• 发表时间: 2016-09
• 期刊: Optometry and vision science : official publication of the American Academy of Optometry
• 作者: Norton TT

Experimental myopia increases and scleral crosslinking using genipin inhibits cyclic softening in the tree shrew sclera.

• DOI: 10.1111/opo.12454
• 发表时间: 2018-05
• 期刊: Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
• 作者: Levy AM;Fazio MA;Grytz R
• 通讯作者: Grytz R