UAB Core Grant for Vision Research

UAB视觉研究中心-整体核心 项目概要/摘要 1979年，NEI核心补助金首次授予UAB。在接下来的41年里，该机构的承诺， 战略增长导致视觉研究的显著扩展。参与者从13人增加到2人 将3个系的人数增加到25人，同时增加了校外资金。二十人 目前持有24个合格的NEI R 01赠款。一名参加者提交了R 01申请， 出色的成绩。三名参与者具有NEI新研究者身份。他们要么是在开，要么是刚开完-- 奖励，并将在此更新期间提交NEI R 01申请。每年，NEI基金超过 1260万美元，不包括UAB内部奖励。UAB与视觉相关研究的校外资金已经 增长到每年近1610万美元。UAB视觉科学家研究视觉神经科学（解剖学，生物学， 视网膜、青光眼和中央视觉通路的化学、生理或心理物理学研究），AMD， 近视、圆锥角膜、干眼症和白内障等。Brian Samuels博士（医学博士，博士）是主任 P30，现在被命名为UAB视觉研究中心核心（CCVR），和行政核心， 并将对核心的所有支出和适当运作负主要责任。他会协调 Steve Pittler博士，UAB机构支持的视觉科学研究中心主任 （VSRC）和CCVR的联合主任，以确保核心资源和服务符合参与者的需求。 该申请要求通过四个方面提供资金，以继续支持参与者的研究活动。 专业人员的核心。每个核心都位于Volker Hall中心，提供最先进的设施， 专门针对每一个目的。《The Machine Shop Core》，导演：Paul Gamiln，PhD.设计和 制造独特的机械装置和维修/维护现有仪器。研究 编程与计算分析核心，由J.克劳福德唐斯，博士指导，提供访问 高端分析工具，包括先进的图像和大数据分析、计算机编程、定制 软件/硬件开发和接口以及数据库开发/管理。分子& 细胞分析核心，由史蒂夫皮特勒，博士，为分子和细胞研究提供专业知识 设计、培训和获得用于DNA、RNA和蛋白质研究以及形态学的主要仪器 组织和细胞的分析。由Timothy Kraft博士指导的眼表型核心，提供了 资源和服务，以协助结构和功能分析的小动物模型的人类眼 疾病和研究设计以及生物统计学分析。自1979年以来，视觉研究已收到超过 1900万美元的机构支持和超过100万美元的承诺，在未来5年的资金周期。UAB拥有 通过专注于使用先进的技术和先进的设备， 招募最好的科学家来研究和设计眼部疾病的治疗方法。P30的延续 视觉研究的核心补助金是UAB视觉科学新发现的核心要素。

UAB Center for Vision Research - Overall Core Project Summary/Abstract In 1979, an NEI Core grant was first awarded to UAB. Over the next 41 years, the institution's commitment to strategic growth resulted in significant expansion of vision research. Participants have increased from 13 in 2 departments to 25 in 3 departments, with a concominant increase in extramural funding. Twenty participants currently hold 24 eligble NEI R01 grants. One participant has submitted an R01 application and received an exceptional score. Three participants have NEI new investigator status. They are either on or just completed K- awards and will be submitting NEI R01 applications during this renewal period. Annually, NEI funds exceed $12.6 million, not including internal UAB awards. Extramural funding for vision-related research at UAB has grown to nearly $16.1 million annually. UAB vision scientists study visual neuroscience (anatomical, bio- chemical, physiological, or psychophysical studies of the retina, glaucoma, and central visual pathways), AMD, myopia, keratoconus, dry eye and cataractogenesis among others. Dr. Brian Samuels MD, PhD is the Director of the P30, now named the UAB Center Cores for Vision Research (CCVR), and the Administrative Core, and will have primary responsibility for all expenditures and proper functioning of the cores. He will coordinate with Dr. Steve Pittler, PhD, Director of the UAB institutionally supported Vision Science Research Center (VSRC) and co-director of the CCVR, to ensure the core resources and services align with participant needs. This application requests funds to provide continued support participants’ research activities through four professionally staffed cores. Each core, centrally located in Volker Hall, provides state-of-the-art facilities and expertise specifically for each purpose. The Machine Shop Core, directed by Paul Gamiln, PhD., designs and fabricates unique mechanical devices and repair/maintenance of current instruments. The Research Programming & Computational Analysis Core, directed by J. Crawford Downs, PhD, provides access to high-end analytical tools including advanced image and big-data analysis, computer programming, custom software/hardware development and interfacing, and database development/management. The Molecular & Cellular Analysis Core, directed by Steve Pittler, PhD., provides expertise for molecular and cellular study designs, training and access to major instrumentation for DNA, RNA and protein studies and morphologic analysis of tissues and cells. The Ocular Phenotyping Core, directed by Timothy Kraft, PhD, provides resources and services to assist with structural and functional analysis of small animal models of human ocular disease and study design and biostatistical analysis. Since 1979, vision research has received more than $19M in institutional support and more than $1M is committed over the next 5 years funding cycle. UAB has grown into a national leader in vision research by focusing on the use of advanced technology and the recruiting the best scientists to study and devise treatments for ocular disorders. The continuation of the P30 core grant for vision research is an essential element at the core of new discovery in vision science at UAB.