Role of Peripheral & Brain Iron in the Development of Attention & Cognitive Control

外设的作用

• 批准号: 9387539
• 负责人: Alison Pritchard
• 金额: $ 24.08万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-10 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9387539
• 关键词: Accidents; Address; Adolescence; Advertisements; Affect; Age; Age-Months; Animal Model; Attention; Attention deficit hyperactivity disorder; Base of the Brain; Behavior; Behavioral; Blood; Brain; Brain region; Child; Childhood; Communities; Corpus striatum structure; Data; Development; Developmental Course; Disease; Dopamine; Eligibility Determination; Emotions; Ensure; Etiology; Evaluation; Goals; Gray unit of radiation dose; Growth; Human; Imaging Techniques; Impairment; Injury; Iron; Link; Longitudinal Studies; Longitudinal prospective study; Magnetic Resonance Imaging; Magnetism; Maps; Measures; Mediating; Medical; Medical Records; Metabolism; Methodology; Neuropsychology; Neurotransmitters; Norepinephrine; Occupational; Oppositional Defiant Disorder; Outcome; Parents; Participant; Peripheral; Pharmaceutical Preparations; Positioning Attribute; Predisposition; Prevalence; Prevention; Problem behavior; Process; Productivity; Recording of previous events; Recruitment Activity; Research; Research Design; Research Domain Criteria; Resolution; Risk Factors; Role; School-Age Population; Services; Societies; Special Education; Systems Development; Techniques; Time Study; Tissues; Visual Perception; anatomic imaging; base; biomarker development; cognitive control; cognitive development; cognitive system; cost; deprivation; experience; externalizing behavior; frontal lobe; gray matter; indexing; infancy; iron deficiency; language perception; myelination; neuroimaging; nonhuman primate; peripheral blood; population based; public health relevance; social; success; symptomatology; teacher; ultra high resolution

PROJECT SUMMARY Emerging research implicates iron deficiency in childhood externalizing disorders featuring deficits in attention and cognitive control, such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Oppositional Defiant Disorder. In children, iron deficiency is hypothesized to contribute to these deficits as a result of iron’s critical role in the synthesis and expression of important neurotransmitters such as dopamine and norepinephrine, in the functioning of the striatum, and in myelination of the frontal lobe, all of which have been linked to impairment in attention and cognitive control in ADHD. Previous research has largely utilized peripheral (blood-based) iron measures in evaluating these associations; however, peripheral iron measures may not accurately represent iron concentrations in the brain. Recent developments in neuroimaging methodologies now allow for non-invasive, ultra-high resolution maps of tissue magnetic susceptibility differences, which correlate strongly with tissue iron concentrations in gray matter. Only two studies to date have assessed the relationship between brain iron concentrations and disorders of attention and cognitive control in children via neuroimaging, with both providing preliminary evidence of reduced brain iron among school-aged children with ADHD symptomatology. The goal of the proposed project is to better understand the early developmental course of brain iron concentration in (human) children and its relationship to critical cognitive systems implicated in externalizing behavior problems. To accomplish this goal, we will recruit 40 children between the ages of 6 and 8 years, half of whom have a history of iron deficiency (measured peripherally) in infancy and half of whom do not. Participants will complete: 1) a high resolution neuroimaging study at 7 Tesla to estimate concurrent brain iron concentrations; 2) a blood draw to assess concurrent peripheral iron concentrations; and 3) a focused neuropsychological assessment to evaluate concurrent attention and cognitive control, as well as other cognitive systems (e.g., language and visual perception) which are hypothesized to be less impacted by early iron deficiency. In addition, participants’ parents and teachers will be asked to complete ratings of behaviors associated with deficits in attention and cognitive control. This study represents the first use of anatomic imaging techniques to evaluate brain iron concentrations in young children, in association with early peripheral iron indices, to determine the relation between iron status and critical cognitive systems.

项目总结