Myoepithelial cell stefin A suppresses breast cancer invasion

肌上皮细胞stefin A抑制乳腺癌侵袭

• 批准号: nhmrc : 1047748
• 负责人: Dr Belinda Parker
• 金额: $ 29.36万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/myoepithelial-cell-stefin-cancer-invasion/111966
• 关键词: Myoepithelial; cell; stefin; suppresses; breast

The mechanisms required for breast cancer cells to spread outside of the ducts and into the surrounding breast tissue are largely unknown. There is increasing evidence that the cell layer surrounding the ducts (myoepithelium) functions to suppress invasion. We aim to test if a protein inhibitor that is expressed in these cells can preventing breast cancer invasion in models of early breast cancer and if its expression can predict those patients that are unlikely to develop invasive cancers.

乳腺癌细胞扩散到导管外并进入周围乳腺组织所需的机制在很大程度上是未知的。越来越多的证据表明，导管周围的细胞层（肌上皮）的功能，以抑制入侵。我们的目标是测试在这些细胞中表达的蛋白质抑制剂是否可以在早期乳腺癌模型中预防乳腺癌侵袭，以及其表达是否可以预测那些不太可能发展为侵袭性癌症的患者。