Tumour induced innate immune responses that control breast cancer metastases

肿瘤诱导的先天免疫反应控制乳腺癌转移

• 批准号: nhmrc : 1047747
• 负责人: Dr Belinda Parker
• 金额: $ 39.75万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tumour-induced-innate-cancer-metastases/111965
• 关键词: Tumour; induced; innate; immune; responses

The mechanisms of breast cancer spread to bone are largely unknown. We have found that cross-talk between tumour cells and the immune system exists to induce anti-tumour immune responses. By decreasing the release of proteins known to activate immune responses (type I interferons), tumour cells can hide from such responses and spread to tissues such as bone. We aim to identify the immune responses activated by type I IFN and if restoration of these pathways can block breast cancer spread to bone.

乳腺癌扩散到骨骼的机制在很大程度上是未知的。我们已经发现，肿瘤细胞和免疫系统之间存在串扰，以诱导抗肿瘤免疫应答。通过减少已知激活免疫反应的蛋白质（I型干扰素）的释放，肿瘤细胞可以隐藏这种反应并扩散到骨等组织。我们的目标是确定I型IFN激活的免疫反应，以及这些途径的恢复是否可以阻止乳腺癌扩散到骨骼。