Characterisation and therapeutic targeting of molecular pathways that promote breast cancer metastasis to bone

促进乳腺癌骨转移的分子途径的表征和治疗靶向

• 批准号: nhmrc : 566553
• 负责人: Dr Belinda Parker
• 金额: $ 29.51万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-therapeutic-targeting-metastasis-bone/115998
• 关键词: Characterisation; therapeutic; targeting; molecular; pathways

Breast cancer that has spread to bone cannot be cured. Using the most clinically relevant model of breast cancer available we have identified that tumour cells growing in bone need to suppress immune elimination (by suppressing the Type I interferons) and invade through the bone tissue (by activation of cysteine cathepsins). Studying the functional role of these pathways will provide novel insight into the mechanisms of breast cancer spread to bone that can be augmented therapeutically.

已经扩散到骨骼的乳腺癌是无法治愈的。使用现有的最临床相关的乳腺癌模型，我们已经确定在骨中生长的肿瘤细胞需要抑制免疫消除（通过抑制I型干扰素）并通过骨组织侵入（通过激活半胱氨酸组织蛋白酶）。研究这些通路的功能作用将为乳腺癌扩散到骨的机制提供新的见解，可以在治疗上增强。