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Diabetic Comorbidity and MERS Coronavirus Pathogenesis

Diabetic Comorbidity and MERS Coronavirus Pathogenesis
糖尿病合并症和 MERS 冠状病毒发病机制
批准号：
9294969
负责人：
Matthew Bryan Frieman
金额：
$19.54万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
项目状态：
已结题
起止时间：
2016-06-13 至 2018-05-31
来源：
https://reporter.nih.gov/project-details/9294969
关键词：
AffectAnimal ModelBrainCamelsCase Fatality RatesCase StudyCessation of lifeChinese PeopleChiropteraClinicalClinical DataCommunitiesComorbidityCoronaviridaeCoronavirusCoronavirus InfectionsCountryDevelopmentDiabetes MellitusDiabetic mouseDipeptidyl-Peptidase IVDiseaseDisease OutbreaksDrug TargetingEndopeptidasesFDA approvedFutureGCG geneGlareGlucoseGovernmentHealth PersonnelHeart DiseasesHospitalsHumanImmune responseImmunosuppressionInfectionInflammatory ResponseInsulinJordanKidney FailureKnowledgeLeadLifeLungMiddle EastMiddle East Respiratory Syndrome CoronavirusMusNeurotransmittersNon-Insulin-Dependent Diabetes MellitusOutcomePathogenesisPathogenicityPatientsPersonsProteinsPublic HealthRoleSaudi ArabiaSouth KoreaSyndromeT-LymphocyteTestingVirusVirus ReplicationViverridaeWorkblood glucose regulationchemokinecohortcomparativecoronavirus receptorcytokinediabeticin vivoinhibitor/antagonistmacrophagemonocytemouse modelnovelpermissivenessreceptorrespiratoryrespiratory virustransmission process

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中文摘要
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英文摘要
Project Summary Here we seek to identify the role of diabetes in Middle East Respiratory Syndrome Coronavirus (MERS-CoV) pathogenesis. MERS-CoV emerged in 2012 in Saudi Arabia leading to over 1700 infections with a ~40% case fatality rate. The majority of lethal MERS-CoV infections are associated with comorbidity, with diabetes as the top comorbidity. We will use a mouse model of MERS-CoV to identify if preexisting Type 2 diabetes exacerbates MERS-CoV disease, how diabetes alters the inflammatory response and protection from MERS-CoV and if drugs targeting a regulator of diabetes can protect mice from MERS-CoV.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
Human Monoclonal Antibody Cocktail for the Treatment or Prophylaxis of Middle East Respiratory Syndrome Coronavirus.
DOI： 10.1093/infdis/jiab036
发表时间： 2022-05-16
期刊： The Journal of infectious diseases
影响因子： --
作者： [Sivapalasingam S, Saviolakis GA, Kulcsar K, Nakamura A, Conrad T, Hassanein M, Sumner G, Elango C, Kamal MA, Eng S, Kyratsous CA, Musser BJ, Frieman M, Kantrowitz J, Weinreich DM, Yancopoulos G, Stahl N, Lipsich L]
通讯作者： Lipsich L
Coronavirus Challenge Core
  • 批准号：
    10420513
  • 项目类别：
  • 资助金额：
    $144.15万
  • 财政年份：
    2022
  • 负责人：
    Matthew Bryan Frieman
  • 依托单位：
    WASHINGTON UNIVERSITY
Broad Spectrum Anti-viral Compounds Targeting the SKI Complex
  • 批准号：
    10183158
  • 项目类别：
  • 资助金额：
    $19.31万
  • 财政年份：
    2020
  • 负责人：
    Matthew Bryan Frieman
  • 依托单位：
    UNIVERSITY OF MARYLAND BALTIMORE
Role of Diabetes in MERS Coronavirus Pathogenesis
  • 批准号：
    10649491
  • 项目类别：
  • 资助金额：
    $55.08万
  • 财政年份：
    2020
  • 负责人：
    Matthew Bryan Frieman
  • 依托单位：
    UNIVERSITY OF MARYLAND BALTIMORE
Role of Diabetes in MERS Coronavirus Pathogenesis
  • 批准号：
    10196973
  • 项目类别：
  • 资助金额：
    $55.69万
  • 财政年份：
    2020
  • 负责人：
    Matthew Bryan Frieman
  • 依托单位：
    UNIVERSITY OF MARYLAND BALTIMORE
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