Diabetic Comorbidity and MERS Coronavirus Pathogenesis

糖尿病合并症和 MERS 冠状病毒发病机制

• 批准号: 9294969
• 负责人: Matthew Bryan Frieman
• 金额: $ 19.54万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-13 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9294969
• 关键词: Affect; Animal Model; Brain; Camels; Case Fatality Rates; Case Study; Cessation of life; Chinese People; Chiroptera; Clinical; Clinical Data; Communities; Comorbidity; Coronaviridae; Coronavirus; Coronavirus Infections; Country; Development; Diabetes Mellitus; Diabetic mouse; Dipeptidyl-Peptidase IV; Disease; Disease Outbreaks; Drug Targeting; Endopeptidases; FDA approved; Future; GCG gene; Glare; Glucose; Government; Health Personnel; Heart Diseases; Hospitals; Human; Immune response; Immunosuppression; Infection; Inflammatory Response; Insulin; Jordan; Kidney Failure; Knowledge; Lead; Life; Lung; Middle East; Middle East Respiratory Syndrome Coronavirus; Mus; Neurotransmitters; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Pathogenesis; Pathogenicity; Patients; Persons; Proteins; Public Health; Role; Saudi Arabia; South Korea; Syndrome; T-Lymphocyte; Testing; Virus; Virus Replication; Viverridae; Work; blood glucose regulation; chemokine; cohort; comparative; coronavirus receptor; cytokine; diabetic; in vivo; inhibitor/antagonist; macrophage; monocyte; mouse model; novel; permissiveness; receptor; respiratory; respiratory virus; transmission process

Project Summary Here we seek to identify the role of diabetes in Middle East Respiratory Syndrome Coronavirus (MERS-CoV) pathogenesis. MERS-CoV emerged in 2012 in Saudi Arabia leading to over 1700 infections with a ~40% case fatality rate. The majority of lethal MERS-CoV infections are associated with comorbidity, with diabetes as the top comorbidity. We will use a mouse model of MERS-CoV to identify if preexisting Type 2 diabetes exacerbates MERS-CoV disease, how diabetes alters the inflammatory response and protection from MERS-CoV and if drugs targeting a regulator of diabetes can protect mice from MERS-CoV.

项目摘要 在这里，我们试图确定糖尿病在中东呼吸综合征中的作用 冠状病毒（MERS-CoV）发病机制。MERS-CoV于2012年在沙特阿拉伯出现 导致超过1700例感染，病死率约为40%。大多数致命的 MERS-CoV感染与合并症有关，糖尿病是最常见的 科摩罗。我们将使用MERS-CoV的小鼠模型来识别先前存在的2型 糖尿病加重MERS-CoV疾病，糖尿病如何改变炎症反应 以及预防MERS-CoV，如果针对糖尿病调节剂的药物可以 保护小鼠免受MERS-CoV感染。

项目成果

Human Monoclonal Antibody Cocktail for the Treatment or Prophylaxis of Middle East Respiratory Syndrome Coronavirus.

• DOI: 10.1093/infdis/jiab036
• 发表时间: 2022-05-16
• 期刊: The Journal of infectious diseases
• 作者: Sivapalasingam S;Saviolakis GA;Kulcsar K;Nakamura A;Conrad T;Hassanein M;Sumner G;Elango C;Kamal MA;Eng S;Kyratsous CA;Musser BJ;Frieman M;Kantrowitz J;Weinreich DM;Yancopoulos G;Stahl N;Lipsich L
• 通讯作者: Lipsich L