Relating episodic memory and episodic future thinking in hippocampus

海马体情景记忆与情景未来思维的关系

• 批准号: 9350391
• 负责人: A DAVID REDISH
• 金额: $ 43.52万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9350391
• 关键词: Animals; Behavior; Cognitive; Complex; Data; Development; Environment; Episodic memory; Event; Food; Future; Goals; Grant; Hippocampus (Brain); Imagination; Learning; Literature; Location; Mathematics; Measures; Memory; Play; Prefrontal Cortex; Process; Rattus; Research Personnel; Rest; Rewards; Role; Running; Signal Transduction; Site; Source; Structure; Techniques; Testing; Thinking; Uncertainty; Use of New Techniques; Work; base; cost; design; experience; improved; information processing; memory consolidation; neural circuit; prospective; relating to nervous system

An extensive literature suggests a role for the prefrontal cortex and hippocampus in episodic memory, particularly in the re-construction of those memories; a growing literature is now suggesting a role for these structures in planning and imagination, particularly in the construction of future potential episodes, a process termed ``episodic future thinking''. These two processes have obvious similarities (they both entail construction of episodic representations) and obvious differences (memory is trying to reconstruct a real past, imagination is trying to hypothesize a potential future). However, it is not known how this neural circuit contributes to these phenomena, nor how the information processing differs between them. New mathematical techniques now allow decoding of represented variables from neural ensembles at very fast timescales, enabling the observation of transient, covert processes. The goal of this proposal is to use these new techniques to track changes in representation at cognitive (10 ms) timescales. Combining newly available multi-structure recording techniques, newly developed tasks, newly improved neural ensemble analysis techniques, and causal manipulations of the prelimbic cortex, we will examine the relationship between the representations of past events and future possibilities in hippocampus to determine the mechanism by which the hippocampus computes these representations.

大量文献表明前额皮质和海马体的作用 在情景记忆中，特别是在这些记忆的重建中；一个 现在越来越多的文献表明这些结构在规划和 想象力，特别是在构建未来潜在情节时， 这个过程被称为“情景未来思考”。这两个过程有明显的 相似之处（它们都需要构建情景表征）和明显的 差异（记忆试图重建真实的过去，想象力试图 假设一个潜在的未来）。然而，目前尚不清楚这种神经回路是如何 导致这些现象的原因，也不是信息处理的不同 他们之间。新的数学技术现在可以解码 以非常快的时间尺度表示来自神经集合的变量，使得 对瞬态、隐蔽过程的观察。该提案的目标是使用 这些新技术用于跟踪认知表征的变化（10 毫秒） 时间尺度。结合新推出的多结构记录技术， 新开发的任务，新改进的神经集成分析技术， 和前边缘皮层的因果操作，我们将检查这种关系 过去事件的表征与未来可能性之间的关系 海马体确定海马体计算的机制 这些陈述。