Development of a Wearable Near-Infrared Blood Alcohol Content Monitor

可穿戴式近红外血液酒精含量监测仪的研制

• 批准号: 9608961
• 负责人: Ryan Timothy Myers
• 金额: $ 23.57万
• 依托单位: VIVONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9608961
• 关键词: Acute; Alcohol consumption; Alcoholic Beverages; Alcohols; Algorithms; American; Automobiles; Blood; Blood alcohol level measurement; Blood flow; Breath Tests; Calibration; Characteristics; Clinical; Clinical Research; Clothing; Communities; Custom; Data; Data Set; Dermal; Development; Devices; Dose; Esthetics; Ethanol; Foundations; Frequencies; General Population; Geography; Goals; Gold; Health; Heart Rate; Hydration status; Individual; Intoxication; Intracranial Pressure; Laboratories; Legal; Light; Medical; Melanins; Methods; Modeling; Monitor; Near-Infrared Spectroscopy; Optics; Organization administrative structures; Output; Persons; Phase; Physiologic Monitoring; Physiological; Physiology; Police; Police officer; Property; Questionnaires; Recording of previous events; Records; Reporting; Research; Scanning; Site; Spectrum Analysis; Stigmatization; Sweat; System; Techniques; Testing; Tissue Viability; Tissues; Translating; United States; User Compliance; Variant; Water; absorption; addiction; alcohol effect; alcohol response; base; density; dosage; help-seeking behavior; human subject; improved; interest; miniaturize; monitoring device; novel; personalized approach; programs; prototype; social stigma; tool; wearable device

Project Summary/Abstract The United States alcoholic beverage market topped $210 Billion in 2014, selling enough alcohol for each American to consume 9.2 liters (2.4 gallons) of pure alcohol in 2013. Due to alcohol consumption's long history and ample financial interest, there has been a great deal of research around alcohol and the benefits and detriments to consuming it. Despite the commonality of alcohol consumption and the ability for users to abuse the intoxicant, there remains a stigma around monitoring blood alcohol content (BAC) in a public forum (e.g. breathalyzers by police officers and breathalyzer controlled automobile ignitions). This stigma generally holds true even when part of a clinical study or while seeking help for an addiction. Thus, there is still a need for a BAC monitoring device that remains out of site or can be camouflaged into everyday items (e.g. clothing, jewelry, accessories), which has yet to be met be current systems. Near-infrared spectroscopy (NIRS) has been used by Vivonics to monitor and report a number of physiologically relevant parameters. Studies have shown the ability to use near-infrared wavelengths to estimate the blood alcohol concentration with a low error of 0.0049% BAC (legally intoxicated BAC is 0.08). The proposed effort will apply this approach but tailor implementation in a way that enables a miniaturized, wearable device which is accurate despite variations in physiology. Utilizing this concept, the goal of the proposed Phase I effort is to develop an accurate and temporally resolute BAC monitoring benchtop prototype. The overall goal of the Phase I effort is to demonstrate feasibility of the miniaturized NIRS approach, paving the way for human subject testing in Phase II. The long term goal of this program is to deliver an accurate and temporally resolute wearable BAC monitoring device that substantially improves subject compliance in clinical and academic research. The proposed program would not only benefit the research community, providing a tool to better understand how alcohol dose and frequency impacts physiological and physiological health, but would also benefit the general public on a larger scale by translating the findings from the research community into more responsible and healthy alcohol consumption practices.

项目总结/摘要 2014年，美国酒精饮料市场超过2100亿美元， 2013年，美国人将消费9.2升（2.4加仑）纯酒精。由于饮酒的历史悠久， 和充足的经济利益，有大量的研究围绕酒精和好处， 尽管酒精消费的共性和用户滥用的能力， 虽然酒精是一种麻醉剂，但在公共论坛上监测血液酒精含量（BAC）仍然是一种耻辱（例如， 由警察进行的呼气测醉器和由呼气测醉器控制的汽车点火装置）。这种耻辱感通常存在于 即使是临床研究的一部分或在寻求成瘾帮助时也是如此。因此，仍然需要一种 BAC监测装置留在现场外或可装入日常用品（如衣服， 珠宝、配饰），这还有待于被当前的系统满足。近红外光谱（NIRS） 由Vivonics用于监测和报告许多生理相关参数。研究表明 使用近红外波长来估计血液酒精浓度的能力， 0.0049% BAC（法定中毒BAC为0.08）。拟议的努力将采用这种方法，但量身定制 本发明提供了一种实现方式，该方式使得能够实现小型化的可穿戴设备，该设备尽管在 physiology.利用这一概念，拟议的第一阶段工作的目标是制定一个准确的， 时间分辨BAC监测台式原型。第一阶段工作的总体目标是证明 小型化NIRS方法的可行性，为第二阶段的人类受试者测试铺平了道路。长 该项目的长期目标是提供一种准确的、时间上可靠的可穿戴式BAC监测设备 这大大提高了受试者在临床和学术研究中的依从性。拟议的方案将 不仅有利于研究界，提供了一种工具，以更好地了解如何酒精剂量和频率 影响生理和生理健康，但也将在更大范围内使公众受益， 将研究界的发现转化为更负责任和健康的酒精消费 实践