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Investigation of subtelomeric gene families in Cryptosporidium

隐孢子虫亚端粒基因家族的研究

基本信息

批准号：
9505635
负责人：
Adam Sateriale
金额：
$ 10.8万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-05 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9505635
关键词：
Adult Affect Africa Age Amino Acid Motifs Antibodies Basic Science Binding Biological Assay Biotin Cells Cessation of life Child Childhood Cryptosporidiosis Cryptosporidium Cryptosporidium parvum Cytoplasmic Granules Developing Countries Diarrhea Disease Family Fellowship Fluorescence Resonance Energy Transfer Gene Family Genetic Genome Grant Immune response Immunocompromised Host Infection Investigation Label Life Life Cycle Stages Ligase Location Malnutrition Measures Methods Microscopy Organelles Parasites Parasitic infection Pathogenesis Patients Peptide Signal Sequences Pharmaceutical Preparations Phenotype Placebos Plasmodium Population Postdoctoral Fellow Protein Family Proteins Research Research Personnel Role Rotavirus Signal Transduction Southeastern Asia Testing Therapeutic Human Experimentation Toxoplasma Transgenic Organisms Vaccines Virulence Factors base epidemiology study fitness fundamental research improved nitazoxanide programs research and development rhoptry tool virtual

项目摘要

Project Summary Cryptosporidiosis is a diarrheal disease that disproportionately affects children and immunocompromised adults. The WHO estimates that in 2010, diarrheal disease accounted for 10.5% of deaths in children; of the known diarrheal diseases, cryptosporidiosis appears to one of the most deadly. Cryptosporidiosis was found second only to rotavirus in attributed cases of moderate-to- severe diarrhea in a multicenter epidemiology study across Africa and Southeast Asia. There are no efficacious drugs, no vaccines in development, and fundamental research on the Cryptosporidium parasite is sorely lacking. The MEDLE and SKSR gene families of Cryptosporidium are subtelomeric, polymorphic, and posses conserved protein motifs that are well known transport signals in the closely related intracellular parasites Plasmodium and Toxoplasma. These `PEXEL-like motifs' direct proteins to be transported out of the parasite and into the infected host cell, where they can remodel the cell and cut off the host immune response. This project aims to understand the function of the MEDLE and SKSR protein families and their role in Cryptosporidium pathogenesis.

项目摘要隐孢子虫病是一种不成比例地影响儿童和免疫力低下的成年人。世界卫生组织估计，2010年， 10.5%的儿童死亡;在已知的疟疾疾病中，隐孢子虫病似乎是其中一种最致命的隐孢子虫病被发现仅次于轮状病毒在归因的情况下，中度至在一项横跨非洲和东南亚的多中心流行病学研究中，没有有效的药物，没有正在开发的疫苗，以及对隐孢子虫的基础研究寄生虫非常缺乏。隐孢子虫的MEDLE和SKSR基因家族是亚端粒的，多态性和非保守的蛋白质基序，是众所周知的运输信号，在密切的相关的细胞内寄生虫疟原虫和弓形虫。这些“PEXEL样基序”指导蛋白质从寄生虫体内被运送到受感染的宿主细胞中，在那里它们可以重塑细胞切断宿主的免疫反应本项目旨在了解MEDLE的功能和SKSR蛋白家族及其在隐孢子虫发病机制中的作用。