Placenta Association of the Americas Conference Grant

 描述（由申请人提供）：胎盘结构和功能的变化不仅会导致严重的妊娠并发症，而且还通过对胎儿未来代谢和心血管疾病的编程来决定终身健康。不幸的是，胎盘功能改变与短期和长期不良结局之间的联系机制非常复杂，并且在很大程度上仍然未知。为了更好地了解胎盘生物学和病理生理学，需要采用多种尖端技术的多学科方法。由于缺乏以胎盘生物学为重点的科学会议，这一领域的进展受到阻碍。这个R13赠款提案的主要目标是满足一个多学科的，互动的论坛，传播新概念和思想交流胎盘研究的迫切需要。第二个目标是在胎盘生物学领域提供一个低成本，高质量的学习环境，这将鼓励研究生，居民，临床和博士后研究员的出勤率和激发兴趣。在我们的会议计划中，我们寻求支持在生殖研究学会（SRI）年度科学会议的前一天举行为期一天的年度会议作为卫星会议。通过这种设计，我们将最大限度地发挥会议的影响，并将允许从研究生到成熟的研究人员的各种基础科学家和临床研究人员参加。会议将有充足的时间进行互动、非正式讨论和建立联系，预计每年将吸引120-150名与会者。该计划将有一个平衡的组合，由该领域的领导人提出的“最先进”的讲座，新兴的概念演示，并由学员简短的谈话。所有发言者都必须提供充足的时间进行提问和讨论。这一提议意义重大，因为会议是及时的，将促进对胎盘生物学的新的科学探究，这有望为未来的创新铺平道路，以开发体内监测胎盘功能的方法，并靶向胎盘进行干预。该提案包括许多创新方面。例如，我们建议每年邀请一位在胎盘生物学以外的研究领域工作的演讲者，以促进对其他研究领域新兴概念的利用和适应。为了给早期职业调查人员提供充足的机会与演讲者联系、讨论和互动，我们建议组织会议午餐，以便在培训中调查人员可以直接接触到一个小组的演讲者。拟议的会议预计将对该领域产生重大和持续的影响，因为它是独一无二的，汇集了世界领先的研究人员，代表了创造性和互动性论坛中的不同但互补的专业知识，这对于解决有关胎盘的复杂科学问题至关重要从胎儿到成年的健康和疾病。

 DESCRIPTION (provided by applicant): Changes in placental structure and function not only cause serious pregnancy complications but also determine life-long health by programming the fetus for future metabolic and cardiovascular disease. Unfortunately, the mechanisms linking altered placental function to poor short- and long-term outcomes are complex and remain largely unknown. To better understand placental biology and pathophysiology, a multidisciplinary approach utilizing a wide array of cutting edge technologies is required. Progress in this area is hampered by the lack of scientific meetings focused on placental biology. The primary objective of this R13 grant proposal is to meet the urgent need of a multidisciplinary, interactive forum for dissemination of novel concepts and exchange of ideas in placental research. The secondary objective is to provide a low cost, high-quality learning environment in the area of placental biology, which will encourage attendance and stimulate interest by graduate students, residents, and clinical and postdoctoral fellows. In our conference plan we seek support for an annual one-day conference as a satellite meeting the day before the Annual Scientific Meeting of the Society of Reproductive Investigation (SRI). By this design we will maximize the impact of the meeting and will allow for attendance of a diverse group of basic scientists and clinical investigators ranging from graduate students to well established researchers. The meeting will allow ample time for interaction, informal discussion and networking and is anticipated to attract 120-150 attendees each year. The program will have a balanced mix of "state of the art" lectures presented by the leaders in the field, emerging concept presentations, and shorter talks by trainees. All speakers will be mandated to provide ample time for questions and discussion. This proposal is significant because the meeting is timely and will promote novel scientific inquiry into placental biology, which is expected to pave the way for future innovation to develop approaches to monitor placental function in vivo and to target the placenta for intervention. The proposal includes numerous innovative aspects. For example, we propose to facilitate the utilization and adaptation of emerging concepts from other research fields by inviting one speaker each year that works in a research area other than placental biology. To provide ample opportunities for early career investigators to connect, discuss, and interact with the speakers we propose to organize the conference lunch so that in training investigators will have direct access to speakers in a small group. The proposed meeting is expected to have significant and sustained impact on the field because it is unique in bringing together world-leading investigators representing diverse but complementary expertise in a creative and interactive forum, which is necessary to address the complex scientific questions pertaining to the role of placenta in determining health and disease from fetal life to adulthood.