Placenta Association of the Americas Conference Grant

项目总结 胎盘结构和功能的改变不仅会导致严重的妊娠并发症，而且还会 通过为胎儿未来的新陈代谢和心血管疾病做好准备来确定终身健康。 不幸的是，将胎盘功能改变与不良的短期和长期结果联系起来的机制是 很复杂，在很大程度上仍不为人所知。为了更好地了解胎盘生物学和病理生理学， 需要利用广泛的尖端技术的多学科方法。这方面的进展 受到关注胎盘生物学的科学会议稀少的阻碍。这样做的主要目标是 R13赠款建议是为了满足一个多学科、互动的论坛的迫切需要，以传播 胎盘研究中的新概念和思想交流，由杰出的演讲者在 前沿研究领域。第二个目标是提供低成本、高质量的学习 环境，在胎盘生物学领域，这将鼓励 培训中的多样化群体和早期调查人员。在我们的会议计划中，我们寻求对年度会议的支持- 作为卫星会议的日间会议在科学学会年会前一天举行 生殖调查(SRI)。通过这种设计，我们将最大限度地发挥会议的影响，并将允许 出席的不同群体的基础科学家和临床研究人员，从研究生到 久负盛名的研究者。会议将有充足的时间进行互动、非正式讨论和 网络，预计每年吸引130-150名与会者。该计划将有一个平衡的组合 由该领域的领导者进行的“最新技术”讲座，新兴概念演示，以及更短的 实习生的演讲。所有发言者将被要求提供充足的时间提问和讨论。这 这项提议意义重大，因为这次会议是及时的，将促进对胎盘的新的科学研究 生物学，这有望为未来的创新铺平道路，开发监测胎盘的方法 在体内发挥作用，并靶向胎盘进行干预。该提案包括许多创新的 方面。例如，我们建议促进使用和改编其他国家的新概念 通过每年邀请一位在胎盘生物学以外的研究领域工作的演讲者来进行研究。至 为早期职业调查人员提供充分的机会与演讲者联系、讨论和互动 我们建议组织会议午餐，以便在培训中调查人员能够直接接触到 一小群人中的发言者。预计拟议中的会议将对以下方面产生重大和持续的影响 因为它在汇集世界领先的研究人员方面是独一无二的，他们代表着不同的 在一个创造性和互动性的论坛中补充专业知识，这是解决复杂问题所必需的 关于胎盘在决定健康和疾病中的作用的科学问题 成人期。

PROJECT SUMMARY Changes in placental structure and function not only cause serious pregnancy complications but also determine life-long health by programming the fetus for future metabolic and cardiovascular disease. Unfortunately, the mechanisms linking altered placental function to poor short- and long-term outcomes are complex and remain largely unknown. To better understand placental biology and pathophysiology, a multidisciplinary approach utilizing a wide array of cutting edge technologies is required. Progress in this area is hampered by the paucity of scientific meetings focused on placental biology. The primary objective of this R13 grant proposal is to meet the urgent need of a multidisciplinary, interactive forum for dissemination of novel concepts and exchange of ideas in placental research by featuring exceptional speakers working in cutting-edge areas of research. The secondary objective is to provide a low cost, high-quality learning environment, in the area of placental biology, which will encourage attendance and active participation by a diverse group of in training and early investigators. In our conference plan we seek support for an annual one- day conference as a satellite meeting the day before the Annual Scientific Meeting of the Society of Reproductive Investigation (SRI). By this design we will maximize the impact of the meeting and will allow for attendance of a diverse group of basic scientists and clinical investigators ranging from graduate students to well established researchers. The meeting will allow ample time for interaction, informal discussion and networking and is anticipated to attract 130-150 attendees each year. The program will have a balanced mix of “state of the art” lectures presented by the leaders in the field, emerging concept presentations, and shorter talks by trainees. All speakers will be mandated to provide ample time for questions and discussion. This proposal is significant because the meeting is timely and will promote novel scientific inquiry into placental biology, which is expected to pave the way for future innovation to develop approaches to monitor placental function in vivo and to target the placenta for intervention. The proposal includes numerous innovative aspects. For example, we propose to facilitate the utilization and adaptation of emerging concepts from other research fields by inviting one speaker each year that works in a research area other than placental biology. To provide ample opportunities for early career investigators to connect, discuss, and interact with the speakers we propose to organize the conference lunch so that in training investigators will have direct access to speakers in a small group. The proposed meeting is expected to have significant and sustained impact on the field because it is unique in bringing together world-leading investigators representing diverse but complementary expertise in a creative and interactive forum, which is necessary to address the complex scientific questions pertaining to the role of placenta in determining health and disease from fetal life to adulthood.