Placenta Association of the Americas Conference Grant

项目摘要 胎盘结构和功能的改变不仅引起严重的妊娠并发症， 通过对胎儿未来代谢和心血管疾病的规划来确定终身健康。 不幸的是，胎盘功能改变与短期和长期不良结局之间的联系机制是 很复杂，大部分都是未知的。为了更好地了解胎盘生物学和病理生理学， 需要采用多学科方法，利用各种尖端技术。这一领域的进展 由于缺乏专注于胎盘生物学的科学会议，这项工作的主要目的是 R13赠款提案是为了满足一个多学科，互动论坛的迫切需要， 胎盘研究中的新概念和思想交流， 前沿研究领域第二个目标是提供低成本、高质量的学习 环境，在胎盘生物学领域，这将鼓励出席和积极参与， 不同的培训和早期研究人员群体。在我们的会议计划中，我们寻求对年度会议的支持- 作为卫星会议的前一天， 生殖调查（SRI）。通过这种设计，我们将最大限度地发挥会议的影响，并将考虑到 出席了一个不同的基础科学家和临床研究人员，从研究生， 完善的研究人员。会议将有充足的时间进行互动、非正式讨论和 网络，预计每年吸引130-150名与会者。该计划将有一个平衡的组合， 由该领域的领导者提出的“最先进”讲座，新兴概念的介绍，以及更短的 学员的谈话。所有发言者都必须留出充足的时间进行提问和讨论。这 这项提案意义重大，因为会议是及时的，将促进对胎盘的新的科学探究。 生物学，这有望为未来的创新铺平道路，开发监测胎盘的方法。 在体内发挥作用并靶向胎盘进行干预。该提案包括许多创新的 方面例如，我们建议促进利用和适应其他领域新出现的概念， 每年邀请一位在胎盘生物学以外的研究领域工作的演讲者。到 为早期职业调查人员提供充足的机会，与演讲者联系，讨论和互动 我们建议组织会议午餐，以便在培训中调查人员能够直接获得 演讲者在一个小团体。预计拟议的会议将对联合国系统产生重大和持续的影响。 该领域，因为它是独一无二的，汇集了世界领先的调查人员代表不同的，但 在一个创造性和互动的论坛上提供互补的专门知识，这是解决复杂的 有关胎盘在决定从胎儿到胎儿的健康和疾病方面的作用的科学问题， 成年

PROJECT SUMMARY Changes in placental structure and function not only cause serious pregnancy complications but also determine life-long health by programming the fetus for future metabolic and cardiovascular disease. Unfortunately, the mechanisms linking altered placental function to poor short- and long-term outcomes are complex and remain largely unknown. To better understand placental biology and pathophysiology, a multidisciplinary approach utilizing a wide array of cutting edge technologies is required. Progress in this area is hampered by the paucity of scientific meetings focused on placental biology. The primary objective of this R13 grant proposal is to meet the urgent need of a multidisciplinary, interactive forum for dissemination of novel concepts and exchange of ideas in placental research by featuring exceptional speakers working in cutting-edge areas of research. The secondary objective is to provide a low cost, high-quality learning environment, in the area of placental biology, which will encourage attendance and active participation by a diverse group of in training and early investigators. In our conference plan we seek support for an annual one- day conference as a satellite meeting the day before the Annual Scientific Meeting of the Society of Reproductive Investigation (SRI). By this design we will maximize the impact of the meeting and will allow for attendance of a diverse group of basic scientists and clinical investigators ranging from graduate students to well established researchers. The meeting will allow ample time for interaction, informal discussion and networking and is anticipated to attract 130-150 attendees each year. The program will have a balanced mix of “state of the art” lectures presented by the leaders in the field, emerging concept presentations, and shorter talks by trainees. All speakers will be mandated to provide ample time for questions and discussion. This proposal is significant because the meeting is timely and will promote novel scientific inquiry into placental biology, which is expected to pave the way for future innovation to develop approaches to monitor placental function in vivo and to target the placenta for intervention. The proposal includes numerous innovative aspects. For example, we propose to facilitate the utilization and adaptation of emerging concepts from other research fields by inviting one speaker each year that works in a research area other than placental biology. To provide ample opportunities for early career investigators to connect, discuss, and interact with the speakers we propose to organize the conference lunch so that in training investigators will have direct access to speakers in a small group. The proposed meeting is expected to have significant and sustained impact on the field because it is unique in bringing together world-leading investigators representing diverse but complementary expertise in a creative and interactive forum, which is necessary to address the complex scientific questions pertaining to the role of placenta in determining health and disease from fetal life to adulthood.