Motor Recovery through Plasticity-Inducing Cortical Stimulation
通过可塑性诱导皮质刺激恢复运动
基本信息
- 批准号:10357993
- 负责人:
- 金额:$ 106.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-01 至 2028-03-31
- 项目状态:未结题
- 来源:
- 关键词:Activities of Daily LivingAffectAnimalsAreaBRAIN initiativeBehavior assessmentBrainBrain regionClinicalClinical ResearchClinical TrialsClinical assessmentsCollaborationsContralateralDevelopmentDevice DesignsDevicesEffectivenessElectrical Stimulation of the BrainElectrocorticogramElectrodesEngineeringEthicsEvoked PotentialsHandHand functionsHumanImpairmentImplantImplanted ElectrodesInfarctionInvestigationMeasuresMotorMovementPainlessParesisPatient-Focused OutcomesPatientsPatternPhasePhysiologicalPilot ProjectsQuality of lifeRecording of previous eventsRecoveryRecovery of FunctionRehabilitation therapyResearchResearch PersonnelRiskSignal TransductionSiteSourceStrokeSurfaceSystemTechnologyTestingTimeUnited States National Institutes of HealthUpper ExtremityWolvesWorkbasedisabilityexpectationexperimental studyfollow-upfunctional improvementhuman subjectimplantable deviceimplantationimprovedmotor deficitmotor recoverymultidisciplinaryneural implantnonhuman primatenovelnovel strategiespost strokeprimary endpointprimary outcomeprogramspublic-private partnershipresponsesoftware developmentstroke recoverystroke therapytool
项目摘要
Limited recovery of function after stroke remains a major problem for millions. Disability persists in
many, especially when hand function is limited. Existing therapies are limited and many have difficulties with
activities of daily living, even after rehabilitation. Electrical stimulation of the brain has been proposed and
used in early studies to try and aid recovery. In animals, stimulation delivered to the brain at precise times may
improve the effect of stimulation. By stimulating at the beginning of movements, or just after another part of
the brain is active, recovery may be enhanced.
We will use recent advances in implanted brain stimulator technology to place wires on the brain
surface in patients who are recovering from stroke. We will stimulate the brain during therapy sessions.
Healthier brain regions near the stroke area will be stimulated at the time of activity of brain regions right over
the stroke. This will allow the two areas to strengthen their connection and improve the effect of therapy.
We will measure motor function before and after these different stimulation patterns. This will establish
the ability to perform these experiments safely, and show that patients can tolerate well these painless
stimulation sessions. We will look at the strength of connections between brain regions and study the brain
networks related to motor function. We believe these connections and networks will become stronger with
brain stimulation. If successful, this preliminary study would offer a new form of treatment for stroke recovery.
中风后功能恢复有限仍然是数百万人的主要问题。残疾持续存在,
很多人,尤其是手功能受限的时候。现有的治疗方法是有限的,许多人有困难,
日常生活活动,即使在康复后。已经提出了对大脑的电刺激,
在早期研究中用于帮助恢复。在动物中,在精确的时间传递到大脑的刺激可以
提高刺激效果。通过在运动开始时刺激,或者在运动的另一部分之后刺激,
大脑活跃,恢复可能会增强。
我们将利用植入式脑刺激器技术的最新进展,在大脑上放置电线
在中风恢复期的患者中出现。我们会在治疗过程中刺激大脑。
中风区域附近的健康大脑区域将在大脑区域活动时受到刺激
中风这将使这两个领域加强联系,提高治疗效果。
我们将在这些不同的刺激模式之前和之后测量运动功能。这将建立
安全地进行这些实验的能力,并表明患者可以很好地忍受这些无痛
刺激会议。我们将观察大脑区域之间的连接强度并研究大脑
与运动功能相关的网络。我们相信,这些联系和网络将变得更加强大,
脑刺激如果成功,这项初步研究将为中风恢复提供一种新的治疗方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Steven C. Cramer其他文献
Learning to perform a novel movement pattern using haptic guidance: slow learning, rapid forgetting, and attractor paths
学习使用触觉引导执行新颖的运动模式:缓慢学习、快速遗忘和吸引子路径
- DOI:
- 发表时间:
2005 - 期刊:
- 影响因子:0
- 作者:
J. Liu;J. Emken;Steven C. Cramer;D. Reinkensmeyer - 通讯作者:
D. Reinkensmeyer
Active versus passive finger movement: Bilateral, overlapping activations
- DOI:
10.1016/s1053-8119(00)91810-x - 发表时间:
2000-05-01 - 期刊:
- 影响因子:
- 作者:
Steven C. Cramer;Keith C. Stegbauer;Robert Price;Kenneth R. Maravilla - 通讯作者:
Kenneth R. Maravilla
Challenges to the census: international trends and a need to consider public health benefits.
人口普查面临的挑战:国际趋势和考虑公共卫生效益的需要。
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:5.2
- 作者:
Robin Taylor Wilson;S. H. Hasanali;Mohamud Sheikh;Steven C. Cramer;G. Weinberg;A. Firth;Stanley H. Weiss;C. L. Soskolne;C. L. Soskolne - 通讯作者:
C. L. Soskolne
Downward adjustment of rehabilitation goals may facilitate post-stroke arm motor recovery.
康复目标的向下调整可能有助于中风后手臂运动恢复。
- DOI:
10.1080/08870446.2023.2211991 - 发表时间:
2023 - 期刊:
- 影响因子:3.3
- 作者:
Y. Cho;Jeremy M. Hamm;J. Heckhausen;Steven C. Cramer - 通讯作者:
Steven C. Cramer
Microgyria in the Distribution of the Middle Cerebral Artery in a Patient With DiGeorge Syndrome
迪乔治综合征患者大脑中动脉分布的小脑回
- DOI:
10.1177/088307389601100619 - 发表时间:
1996 - 期刊:
- 影响因子:1.9
- 作者:
Steven C. Cramer;P. Schaefer;K. Krishnamoorthy - 通讯作者:
K. Krishnamoorthy
Steven C. Cramer的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Steven C. Cramer', 18)}}的其他基金
Validation of Early Prognostic Data for Recovery Outcomes after Stroke for Future, Higher Yield Trials (VERIFY)
验证中风后恢复结果的早期预后数据,以进行未来更高产量的试验(VERIFY)
- 批准号:
10183797 - 财政年份:2021
- 资助金额:
$ 106.51万 - 项目类别:
Validation of Early Prognostic Data for Recovery Outcomes after Stroke for Future, Higher Yield Trials (VERIFY)
验证中风后恢复结果的早期预后数据,以进行未来更高产量的试验(VERIFY)
- 批准号:
10474279 - 财政年份:2021
- 资助金额:
$ 106.51万 - 项目类别:
Brain-computer interface-functional electrical stimulation for stroke recovery
脑机接口-功能性电刺激促进中风康复
- 批准号:
9897645 - 财政年份:2019
- 资助金额:
$ 106.51万 - 项目类别:
Brain-computer interface-functional electrical stimulation for stroke recovery
脑机接口-功能性电刺激促进中风康复
- 批准号:
10614001 - 财政年份:2019
- 资助金额:
$ 106.51万 - 项目类别:
Brain-computer interface-functional electrical stimulation for stroke recovery
脑机接口-功能性电刺激促进中风康复
- 批准号:
10375436 - 财政年份:2019
- 资助金额:
$ 106.51万 - 项目类别:
Genetic variation, stress, and functional outcomes after stroke rehabilitation
中风康复后的遗传变异、压力和功能结果
- 批准号:
9461626 - 财政年份:2015
- 资助金额:
$ 106.51万 - 项目类别:
Genetic variation, stress, and functional outcomes after stroke rehabilitation
中风康复后的遗传变异、压力和功能结果
- 批准号:
9246343 - 财政年份:2015
- 资助金额:
$ 106.51万 - 项目类别:
Genetic variation, stress, and functional outcomes after stroke rehabilitation
中风康复后的遗传变异、压力和功能结果
- 批准号:
9901581 - 财政年份:2015
- 资助金额:
$ 106.51万 - 项目类别:
相似海外基金
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 106.51万 - 项目类别:
Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 106.51万 - 项目类别:
Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 106.51万 - 项目类别:
Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 106.51万 - 项目类别:
Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 106.51万 - 项目类别:
Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 106.51万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 106.51万 - 项目类别:
Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
- 批准号:
2301846 - 财政年份:2023
- 资助金额:
$ 106.51万 - 项目类别:
Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 106.51万 - 项目类别:
Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
- 批准号:
23K16076 - 财政年份:2023
- 资助金额:
$ 106.51万 - 项目类别:
Grant-in-Aid for Early-Career Scientists