Molecular and Cellular Dynamics in Mammalian Signal Transduction
Molecular and Cellular Dynamics in Mammalian Signal Transduction
批准号:
10357871
负责人:
NATALIE G. AHN
金额:
$57.47万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-04-01 至 2025-01-31
关键词:
AddressAffinityCellsComplexDiseaseDissectionHumanKnowledgeLaboratoriesMAPK1 geneMalignant NeoplasmsMicroscopicMitogen-Activated Protein KinasesMolecularMotionNamesOrganellesPhosphorylationProcessProtein KinaseProteinsPublic HealthRegulationResearchSignal TransductionStructureWorkcell motilitydirectional cellhuman diseaseinhibitornovel therapeutics
中文摘要
项目摘要
MIRA的这一建议涉及我们实验室发现的两个重要途径。在
第一部分,我们将研究磷酸化MAP的变构激活机制
激酶,ERK 2。该项目通过展示蛋白质运动方式,
ERK 2的催化活化的基础,以及这如何影响高亲和力的作用,
抑制剂的在第2部分中,我们将研究控制
后极化细胞复合体,命名为WRAMP结构。WRAMP结构的进步
细胞运动领域,作为一种新的机制,控制定向细胞的持久性
迁移和细胞运动的方向。这些项目是统一的解剖
控制细胞信号动态的分子机制。这发生在微观层面
通过蛋白激酶的分子运动,以及在宏观水平上通过
细胞蛋白质-细胞器复合物。
英文摘要
PROJECT SUMMARY
This MIRA proposal addresses two important avenues of discovery made by our laboratory. In
Part 1, we will examine the mechanism of allosteric activation by phosphorylation of the MAP
kinase, ERK2. This project advances the protein kinase field, by showing how protein motions
underlie the catalytic activation of ERK2 and how this impacts the action of high affinity
inhibitors. In Part 2, we will examine the mechanisms controlling the assembly and function of a
rear-polarized cellular complex, named the WRAMP structure. The WRAMP structure advances
the field of cell motility, as a new mechanism that controls the persistence of directional cell
migration and the direction of cell movement. The projects are unified by their dissection of
molecular mechanisms that control dynamics in cell signaling. This occurs at a microscopic level
by the molecular motions of protein kinases and at a macroscopic level by the assembly of
cellular protein-organelle complexes.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Predoctoral Training Program in Signaling and Cellular Regulation
-
批准号:10442543
-
项目类别:
-
资助金额:$53.2万
-
财政年份:2021
-
负责人:NATALIE G. AHN
-
依托单位:
Predoctoral Training Program in Signaling and Cellular Regulation
-
批准号:10270785
-
项目类别:
-
资助金额:$49.28万
-
财政年份:2021
-
负责人:NATALIE G. AHN
-
依托单位:
Predoctoral Training Program in Signaling and Cellular Regulation
-
批准号:10612084
-
项目类别:
-
资助金额:$54.42万
-
财政年份:2021
-
负责人:NATALIE G. AHN
-
依托单位:
Predoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome Supplement
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批准号:10851494
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项目类别:
-
资助金额:$18.14万
-
财政年份:2021
-
负责人:NATALIE G. AHN
-
依托单位:
Molecular and Cellular Dynamics in Mammalian Signal Transduction
-
批准号:10571691
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项目类别:
-
资助金额:$57.44万
-
财政年份:2020
-
负责人:NATALIE G. AHN
-
依托单位:
Molecular and Cellular Dynamics in Mammalian Signal Transduction
-
批准号:10799380
-
项目类别:
-
资助金额:$5.48万
-
财政年份:2020
-
负责人:NATALIE G. AHN
-
依托单位:
Technologies to Define and Map Novel Interorganelle Macromolecular Interactions
-
批准号:8488980
-
项目类别:
-
资助金额:$41.18万
-
财政年份:2013
-
负责人:NATALIE G. AHN
-
依托单位:
Technologies to Define and Map Novel Interorganelle Macromolecular Interactions
-
批准号:9059730
-
项目类别:
-
资助金额:$39.87万
-
财政年份:2013
-
负责人:NATALIE G. AHN
-
依托单位:
Technologies to Define and Map Novel Interorganelle Macromolecular Interactions
-
批准号:8683197
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项目类别:
-
资助金额:$39.87万
-
财政年份:2013
-
负责人:NATALIE G. AHN
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依托单位:
A High-memory Supercomputer for Proteomics, Text Mining and Microbiome Research
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批准号:8334437
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项目类别:
-
资助金额:$190.0万
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财政年份:2013
-
负责人:NATALIE G. AHN
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依托单位:
STRUCTURAL STUDIES OF WNT5A CONTROL OF CELL POLARITY AND DIRECTIONAL MOVEMENT
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批准号:8362542
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项目类别:
-
资助金额:$1.06万
-
财政年份:2011
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负责人:NATALIE G. AHN
-
依托单位:
STRUCTURAL STUDIES OF WNT5A CONTROL OF CELL POLARITY AND DIRECTIONAL MOVEMENT
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批准号:8170840
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项目类别:
-
资助金额:$1.25万
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财政年份:2010
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负责人:NATALIE G. AHN
-
依托单位:
ABI Elite ESI-QqTOF Mass Spectrometry System
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批准号:7792846
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项目类别:
-
资助金额:$45.84万
-
财政年份:2010
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负责人:NATALIE G. AHN
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依托单位:
2010 US-HUPO Conference -- Proteomics from Bench to Clinic
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批准号:7916270
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项目类别:
-
资助金额:$3.3万
-
财政年份:2010
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负责人:NATALIE G. AHN
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依托单位:
STRUCTURAL STUDIES OF WNT5A CONTROL OF CELL POLARITY AND DIRECTIONAL MOVEMENT
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批准号:7955059
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项目类别:
-
资助金额:$1.07万
-
财政年份:2009
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负责人:NATALIE G. AHN
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依托单位:
TRAINING IN SIGNALING AND CELLULAR REGULATION
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批准号:7890804
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项目类别:
-
资助金额:$12.9万
-
财政年份:2009
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负责人:NATALIE G. AHN
-
依托单位:
STRUCTURAL STUDIES OF WNT5A CONTROL OF CELL POLARITY AND DIRECTIONAL MOVEMENT
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批准号:7722851
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项目类别:
-
资助金额:$0.92万
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财政年份:2008
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负责人:NATALIE G. AHN
-
依托单位:
Signal Transduction Pathways in Melanoma
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批准号:8050166
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项目类别:
-
资助金额:$26.02万
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财政年份:2007
-
负责人:NATALIE G. AHN
-
依托单位:
Regulation of Map Kinase by Protein Motions
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批准号:7197867
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项目类别:
-
资助金额:$24.92万
-
财政年份:2007
-
负责人:NATALIE G. AHN
-
依托单位:
Signal Transduction Pathways in Melanoma
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批准号:7262679
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项目类别:
-
资助金额:$26.89万
-
财政年份:2007
-
负责人:NATALIE G. AHN
-
依托单位:
海外基金