Predoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome Supplement

信号传导和细胞调节博士前培训计划包括唐氏综合症补充剂

• 批准号: 10851494
• 负责人: NATALIE G. AHN
• 金额: $ 18.14万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10851494
• 关键词: Down Syndrome; Signal Transduction; Training Programs; cell growth regulation; pre-doctoral

SUMMARY The goal of the NIGMS T32 Predoctoral Training Program in Signaling and Cell Regulation is to prepare predoctoral trainees for productive research careers in the field of signaling and cellular regulation. The training faculty mentors consist of an outstanding, internationally recognized group of researchers in the Department of Biochemistry (BCHM) and the Department of Molecular, Cellular and Developmental Biology (MCDB) at the University of Colorado, Boulder, who study basic cell regulatory mechanisms through discovery and characterization of key components in biological pathways. The program mentors students to gain critical thinking skills and depth in understanding how to assimilate different scientific areas to solve problems in modern molecular biosciences, and teaches them how to use apply these skills when they enter the biomedical research workforce. Program elements include program-specific elective courses, an annual Symposium, Supergroup research conferences, seminars, and journal clubs, together with trainee monitoring through thesis committees and organizational meetings. These approaches expose students to broad, interdisciplinary scientific areas through cross-disciplinary mentorship and collaboration; provide them with rigorous training in experimental design, classical and modern technologies, and data analysis, with high standards for reproducibility; foster a proactive community effort to promote the recruitment and retention of underrepresented trainees; and support students’ progress and ability to work in teams in an inclusive environment through all aspects of their training. Coursework on responsible conduct of research instills students with an awareness of norms and expectations for conducting research with high ethical standards. Professional development and career training workshops expose students to diverse career trajectories and opportunities, with experiential coaching for planning and landing employment. By integrating SCR Program- specific coursework and activities with departmental graduate program requirements, and through mindful and responsive mentoring, the Program creates a thriving collaborative and interdisciplinary graduate training environment. The current proposal requests an INCLUDE Down syndrome supplement to the existing parent T32 program. As articulated in the proposal, 10 of the 36 SCR Training Program faculty and their students are already actively engaged in Down syndrome-related research and training of graduate students and postdocs in this field. Thus, the SCR Training Program is well positioned, both scientifically and administratively, to oversee the mentorship of graduate students interested in Down syndrome-related research. Therefore, this proposal is perfectly aligned with the NIH INCLUDE Project Research Plan Component 1: Targeted high risk - high reward basic science studies in areas highly relevant to Down syndrome.

总结 NIGMS T32信号传导和细胞调节博士前培训计划的目标是 准备在信号和细胞调控领域的生产性研究职业的博士前学员。 培训教师导师包括一个杰出的，国际公认的研究人员在 生物化学系（BCHM）和分子，细胞和发育生物学系 科罗拉多大学博尔德分校（University of Colorado，Boulder）的MCDB，他们通过发现来研究基本的细胞调节机制， 和生物途径中关键成分的表征。该计划指导学生获得关键的 理解如何吸收不同的科学领域来解决问题的思维能力和深度， 现代分子生物科学，并教他们如何使用这些技能，当他们进入 生物医学研究人员。计划内容包括特定计划的选修课程，每年 专题讨论会、超群研究会议、研讨会和期刊俱乐部，以及学员监督 通过论文委员会和组织会议。这些方法使学生接触到广泛的， 通过跨学科的指导和合作，跨学科的科学领域;为他们提供 在实验设计，古典和现代技术，数据分析，严格的培训，高 可重复性的标准;促进积极的社区努力，以促进招聘和保留 代表性不足的学员;并支持学生的进步和能力，在一个包容性的团队工作， 环境的各个方面进行培训。关于研究机构负责任行为的课程 学生对规范和期望的认识，以高道德标准进行研究。 专业发展和职业培训研讨会让学生接触到不同的职业轨迹， 机会，与规划和登陆就业经验辅导。通过整合SCR计划- 具体的课程和活动与部门研究生课程的要求，并通过铭记 和响应辅导，该计划创造了一个蓬勃发展的合作和跨学科的研究生培训 环境 目前的提案要求将唐氏综合征补充纳入现有的母体T32 程序.正如提案中所阐述的那样，36名SCR培训计划教师及其学生中有10名是 已经积极从事唐氏综合征相关的研究和研究生及博士后的培训 在该领域因此，SCR培训计划在科学和管理上都处于有利地位， 监督对唐氏综合症相关研究感兴趣的研究生的导师。因此本 该提案与NIH INCLUDE项目研究计划组件1完全一致：针对高风险 - 在与唐氏综合症高度相关的领域进行高回报的基础科学研究。

项目成果

Emerging roles for endogenous retroviruses in immune epigenetic regulation.

• DOI: 10.1111/imr.13042
• 发表时间: 2022-01
• 期刊: Immunological reviews
• 影响因子: 8.7
• 作者: Buttler CA;Chuong EB
• 通讯作者: Chuong EB

UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS.

• DOI: 10.7554/elife.79452
• 发表时间: 2023-03-23
• 期刊: eLife
• 影响因子: 7.7
• 作者: Black HH;Hanson JL;Roberts JE;Leslie SN;Campodonico W;Ebmeier CC;Holling GA;Tay JW;Matthews AM;Ung E;Lau CI;Whiteley AM
• 通讯作者: Whiteley AM

A biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activation.

• DOI: 10.1126/scisignal.2005680
• 发表时间: 2015-02-24
• 期刊: Science signaling
• 影响因子: 7.3
• 作者: Chapnick DA;Bunker E;Liu X
• 通讯作者: Liu X

An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion.

• DOI: 10.7554/elife.84279
• 发表时间: 2022-11-30
• 期刊: eLife
• 影响因子: 7.7
• 作者: Nguyen TT;Voeltz GK
• 通讯作者: Voeltz GK

Enhancer RNA profiling predicts transcription factor activity.

• DOI: 10.1101/gr.225755.117
• 发表时间: 2018-03-01
• 期刊: Genome research
• 影响因子: 7
• 作者: Azofeifa JG;Allen MA;Hendrix JR;Read T;Rubin JD;Dowell RD
• 通讯作者: Dowell RD