Predoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome Supplement

摘要 NIGMS T32信号和细胞调节博士前培训计划的目标是 为在信号和细胞调节领域从事富有成效的研究工作的博士前实习生做准备。 培训教师导师由一群杰出的、国际公认的研究人员组成 生物化学系(BCHM)和分子、细胞与发育生物学系 科罗拉多大学博尔德分校的(MCDB)，他通过发现研究基本的细胞调控机制 以及生物途径中关键成分的表征。该计划指导学生获得批判性的 理解如何吸收不同科学领域来解决问题的思维能力和深度 现代分子生物科学，教他们如何使用这些技能，当他们进入 生物医学研究队伍。课程内容包括特定于课程的选修课，每年一次 研讨会、超级小组研究会议、研讨会和期刊俱乐部，以及学员监控 通过论文委员会和组织会议。这些方法使学生接触到广泛的、 通过跨学科的指导和协作，在跨学科科学领域开展合作；为他们提供 严格的实验设计、经典和现代技术以及数据分析方面的培训，具有较高的 可再生性标准；促进社区积极努力，促进招聘和保留 代表不足的受训人员；并支持学生的进步和在包容性的团队工作中的能力 通过培训的方方面面来改善环境。关于负责任的研究灌输行为的课程作业 具有规范意识和对以高道德标准进行研究的期望的学生。 专业发展和职业培训研讨会让学生了解不同的职业轨迹和 机会，有经验的指导，以规划和实现就业。通过集成SCR计划- 具体的课程和活动符合系研究生课程的要求，并通过意识 和响应性的指导，该计划创造了蓬勃发展的协作式和跨学科的研究生培训 环境。 当前的提案要求对现有的亲本T32添加包括唐氏综合症 程序。如提案所述，36名SCR培训计划的10名教职员工和他们的学生 已积极从事唐氏综合症相关研究和培训的研究生和博士后 在这个领域。因此，SCR培训计划在科学和管理上都处于有利地位，以 监督对唐氏综合症相关研究感兴趣的研究生的指导。因此，这 建议与NIH包括项目研究计划组成部分1：定向高风险完全一致 -在与唐氏综合症高度相关的领域进行高回报的基础科学研究。

SUMMARY The goal of the NIGMS T32 Predoctoral Training Program in Signaling and Cell Regulation is to prepare predoctoral trainees for productive research careers in the field of signaling and cellular regulation. The training faculty mentors consist of an outstanding, internationally recognized group of researchers in the Department of Biochemistry (BCHM) and the Department of Molecular, Cellular and Developmental Biology (MCDB) at the University of Colorado, Boulder, who study basic cell regulatory mechanisms through discovery and characterization of key components in biological pathways. The program mentors students to gain critical thinking skills and depth in understanding how to assimilate different scientific areas to solve problems in modern molecular biosciences, and teaches them how to use apply these skills when they enter the biomedical research workforce. Program elements include program-specific elective courses, an annual Symposium, Supergroup research conferences, seminars, and journal clubs, together with trainee monitoring through thesis committees and organizational meetings. These approaches expose students to broad, interdisciplinary scientific areas through cross-disciplinary mentorship and collaboration; provide them with rigorous training in experimental design, classical and modern technologies, and data analysis, with high standards for reproducibility; foster a proactive community effort to promote the recruitment and retention of underrepresented trainees; and support students’ progress and ability to work in teams in an inclusive environment through all aspects of their training. Coursework on responsible conduct of research instills students with an awareness of norms and expectations for conducting research with high ethical standards. Professional development and career training workshops expose students to diverse career trajectories and opportunities, with experiential coaching for planning and landing employment. By integrating SCR Program- specific coursework and activities with departmental graduate program requirements, and through mindful and responsive mentoring, the Program creates a thriving collaborative and interdisciplinary graduate training environment. The current proposal requests an INCLUDE Down syndrome supplement to the existing parent T32 program. As articulated in the proposal, 10 of the 36 SCR Training Program faculty and their students are already actively engaged in Down syndrome-related research and training of graduate students and postdocs in this field. Thus, the SCR Training Program is well positioned, both scientifically and administratively, to oversee the mentorship of graduate students interested in Down syndrome-related research. Therefore, this proposal is perfectly aligned with the NIH INCLUDE Project Research Plan Component 1: Targeted high risk - high reward basic science studies in areas highly relevant to Down syndrome.