Predoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome Supplement

信号传导和细胞调节博士前培训计划包括唐氏综合症补充剂

• 批准号: 10851494
• 负责人: NATALIE G. AHN
• 金额: $ 18.14万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10851494
• 关键词: Down Syndrome; Signal Transduction; Training Programs; cell growth regulation; pre-doctoral

SUMMARY The goal of the NIGMS T32 Predoctoral Training Program in Signaling and Cell Regulation is to prepare predoctoral trainees for productive research careers in the field of signaling and cellular regulation. The training faculty mentors consist of an outstanding, internationally recognized group of researchers in the Department of Biochemistry (BCHM) and the Department of Molecular, Cellular and Developmental Biology (MCDB) at the University of Colorado, Boulder, who study basic cell regulatory mechanisms through discovery and characterization of key components in biological pathways. The program mentors students to gain critical thinking skills and depth in understanding how to assimilate different scientific areas to solve problems in modern molecular biosciences, and teaches them how to use apply these skills when they enter the biomedical research workforce. Program elements include program-specific elective courses, an annual Symposium, Supergroup research conferences, seminars, and journal clubs, together with trainee monitoring through thesis committees and organizational meetings. These approaches expose students to broad, interdisciplinary scientific areas through cross-disciplinary mentorship and collaboration; provide them with rigorous training in experimental design, classical and modern technologies, and data analysis, with high standards for reproducibility; foster a proactive community effort to promote the recruitment and retention of underrepresented trainees; and support students’ progress and ability to work in teams in an inclusive environment through all aspects of their training. Coursework on responsible conduct of research instills students with an awareness of norms and expectations for conducting research with high ethical standards. Professional development and career training workshops expose students to diverse career trajectories and opportunities, with experiential coaching for planning and landing employment. By integrating SCR Program- specific coursework and activities with departmental graduate program requirements, and through mindful and responsive mentoring, the Program creates a thriving collaborative and interdisciplinary graduate training environment. The current proposal requests an INCLUDE Down syndrome supplement to the existing parent T32 program. As articulated in the proposal, 10 of the 36 SCR Training Program faculty and their students are already actively engaged in Down syndrome-related research and training of graduate students and postdocs in this field. Thus, the SCR Training Program is well positioned, both scientifically and administratively, to oversee the mentorship of graduate students interested in Down syndrome-related research. Therefore, this proposal is perfectly aligned with the NIH INCLUDE Project Research Plan Component 1: Targeted high risk - high reward basic science studies in areas highly relevant to Down syndrome.

概括 NIGMS T32信号传导和细胞调节中的T32前训练计划的目标是 为信号传导和细胞调节领域的产品研究职业准备前学员。 培训教师导师包括一个杰出的国际认可的研究人员 生物化学系（BCHM）和分子，细胞和发育生物学系 （MCDB）在科罗拉多大学，博尔德分校，他们通过发现研究基本的细胞调节机制 以及生物学途径中关键成分的表征。该计划指导学生获得关键 思考技巧和深度了解如何吸收不同的科学领域以解决问题 现代分子生物科学，并教他们如何使用这些技能时如何使用这些技能 生物医学研究人员。计划元素包括特定计划的选修课程，年度 研讨会，超级研究会议，半岛和期刊俱乐部，以及受训者的监视 通过论文委员会和组织会议。这些方法使学生变得广泛， 跨学科的科学领域通过跨学科的精神和协作；提供他们 实验设计，古典技术和现代技术以及数据分析的严格培训， 繁殖标准；促进积极的社区努力，以促进招募和保留 代表性不足的学员；并支持学生的进度和能力在包容性的团队中工作 通过培训的各个方面的环境。负责任的研究灌输课程 意识到规范和期望以高道德标准进行研究的学生。 专业发展和职业培训研讨会使学生暴露于潜水的职业轨迹和 机会，并提供专家指导，以计划和着陆就业。通过集成SCR程序 - 具有部门研究生课程要求的特定课程和活动，并通过正念 和敏感的心理，该计划创造了一个蓬勃发展的协作和跨学科的研究生培训 环境。 当前提案要求包括唐氏综合症补充到现有父母T32 程序。正如提案中所阐明的那样，36个SCR培训计划中的10位及其学生是 已经积极从事唐氏综合症有关的研究和研究生和博士后的培训 在这个领域。这就是科学和行政上的SCR培训计划的位置很好 监督对唐氏综合症有关的研究感兴趣的研究生的心态。因此，这个 提案与NIH完全一致，包括项目研究计划组件1：针对性的高风险 - 高度奖励与唐氏综合症高度相关的领域的基础科学研究。

项目成果

Conducting a microbiome study.

• DOI: 10.1016/j.cell.2014.06.037
• 发表时间: 2014-07-17
• 期刊: Cell
• 影响因子: 64.5
• 作者: Goodrich JK;Di Rienzi SC;Poole AC;Koren O;Walters WA;Caporaso JG;Knight R;Ley RE
• 通讯作者: Ley RE

Design and application of genetically encoded biosensors.

• DOI: 10.1016/j.tibtech.2010.12.004
• 发表时间: 2011-03
• 期刊: TRENDS IN BIOTECHNOLOGY
• 影响因子: 17.3
• 作者: Palmer, Amy E.;Qin, Yan;Park, Jungwon Genevieve;McCombs, Janet E.
• 通讯作者: McCombs, Janet E.

Enhancer RNA profiling predicts transcription factor activity.

• DOI: 10.1101/gr.225755.117
• 发表时间: 2018-03-01
• 期刊: Genome research
• 影响因子: 7
• 作者: Azofeifa JG;Allen MA;Hendrix JR;Read T;Rubin JD;Dowell RD
• 通讯作者: Dowell RD

An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion.

• DOI: 10.7554/elife.84279
• 发表时间: 2022-11-30
• 期刊: eLife
• 影响因子: 7.7
• 作者: Nguyen TT;Voeltz GK
• 通讯作者: Voeltz GK

UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS.

• DOI: 10.7554/elife.79452
• 发表时间: 2023-03-23
• 期刊: eLife
• 影响因子: 7.7
• 作者: Black HH;Hanson JL;Roberts JE;Leslie SN;Campodonico W;Ebmeier CC;Holling GA;Tay JW;Matthews AM;Ung E;Lau CI;Whiteley AM
• 通讯作者: Whiteley AM