NCI National Clinical Trials Network - Network Lead Academic Participating Sites (UG1)

项目摘要/摘要 诺里斯·科顿癌症中心(NCCC)，两个癌症相关活动的重点 达特茅斯学院，包括它的盖泽尔医学院和达特茅斯-希区柯克健康学院， 将作为牵头学者参与NCI的国家临床试验网络 地点。NCCC在国家合作小组临床试验、日期测定方面有着悠久的领导历史 回到CALGB的运营中心，最近又成为CALGB的主要成员 肿瘤学、NRG、COG和ECOG/ACRIN临床试验联盟。作为唯一的NCI- 新英格兰北部指定的综合癌症中心，NCCC目前为 每年超过5,000名新患者和30,000名癌症回归患者。NCCC是我们的特色菜 佛蒙特州和新罕布夏州学术中心，建立了一个由17个社区组成的网络 该地区各地的实习地点，并收到罕见和晚期癌症的转诊，目标是 来自一个大的地理集水区，用于注册创新临床试验的人口。 在达特茅斯，NCCC有一个中央临床研究办公室(OCR)，负责协调 参与所有可用的临床试验。NCCC打算全面参与所有 NCTN活动，扩大其先前对参与联盟的关注。NCCC调查人员 积极参与多个NCTN运营中心委员会，促进双向整合 将NCCC的概念纳入NCTN，而NCTN的研究将无缝地纳入 NCCC试验组合。我们预计55名同意的受试者将获得高绩效的应计利润 对治疗试验的干预和20名受试者的筛查只对治疗或 成像试验。卫生署的护理服务分为17个指定的跨科疾病 汇集所有相关专科的团队，每周14个，为新患者服务 对临床试验登记资格进行例行评估的会议。NCCC 分配到这些临床肿瘤学小组(COG)的研究护士负责 让团队了解可用的试验，以及NCCC临床试验管理系统 (Velos EResearch)为团队提供跟踪当前注册情况的报告。虽然最高 优先考虑将NCCC的科学转化为临床应用，达特茅斯的规模排除了 大多数单机构研究和国家合作团体试验优先于 为完成NCCC的临床研究任务而发起的行业研究。

Project Summary/Abstract Norris Cotton Cancer Center (NCCC), the keystone of the cancer-related activities of both Dartmouth College, including its Geisel School of Medicine, and Dartmouth-Hitchcock Health, will participate in the NCI's National Clinical Trials Network as a Lead Academic Participating Site. NCCC has a long history of leadership in national cooperative group clinical trials, dating back to serving as an operating center for CALGB, and more recently as a main member of the Alliance for Clinical Trial in Oncology, NRG, COG, and ECOG/ACRIN. As the only NCI- designated Comprehensive Cancer Center in northern New England, NCCC currently serves annually over 5,000 new patients and 30,000 returning cancer patients. NCCC is the specialty academic center for Vermont and New Hampshire, anchoring a network of 17 community-based practice sites across the region and receiving referrals of rare and advanced cancers, the target population for enrollment on innovative clinical trials, from a large geographic catchment area. Within Dartmouth, NCCC has a central Office of Clinical Research (OCR) which coordinates full participation in the entire range of available clinical trials. NCCC intends to participate fully in all NCTN activities, expanding its prior focus on participation in the Alliance. NCCC investigators are active in many NCTN Operations Center committees, facilitating a bi-directional integration of NCCC concepts into the NCTN, while NCTN studies will be seamless incorporated into the NCCC trial portfolio. We anticipate accrual of 55 consented subjects on high performance intervention for treatment trials and 20 subjects on screening only accruals for treatment or imaging trials. Care at DH is organized into 17 designated interdisciplinary disease-based teams which bring together all relevant specialties, 14 on a weekly basis, for new patient conferences at which eligibility for enrollment on clinical trials is assessed routinely. NCCC research nurses assigned to these Clinical Oncology Groups (COGs) are responsible for keeping the teams informed of available trials, and the NCCC clinical trials management system (Velos eResearch) provides the teams reports tracking current enrollment. While highest priority is given to translating NCCC science into clinical application, Dartmouth's size precludes most single-institution studies, and national cooperative group trials are prioritized ahead of industry-initiated studies for fulfillment of NCCC's clinical research mission.