NCI National Clinical Trials Network - Network Lead Academic Participating Sites (UG1)

NCI 国家临床试验网络 - 网络主导学术参与站点 (UG1)

• 批准号: 10581527
• 负责人: Konstantin H. Dragnev
• 金额: $ 43.44万
• 依托单位: DARTMOUTH-HITCHCOCK CLINIC
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10581527
• 关键词: Address; Adolescent and Young Adult; Adult; Advanced Malignant Neoplasm; American College of Radiology Imaging Network; Back; Basic Science; Cancer Center; Cancer Patient; Cancer and Leukemia Group B; Caring; Catchment Area; Clinical; Clinical Cancer Center; Clinical Oncology; Clinical Research; Clinical Treatment; Clinical Trials; Clinical Trials Cooperative Group; Collaborations; Combined Modality Therapy; Comprehensive Cancer Center; Conduct Clinical Trials; Consent; Development; Diagnosis; Diagnostic; Disease; Eastern Cooperative Oncology Group; Education; Eligibility Determination; Engineering; Enrollment; Evaluation; Faculty; Funding; Funding Opportunities; Future; Geographic Locations; Geography; Goals; Health; Health system; Image; Immunologics; Immunology; Immunotherapeutic agent; Industry; Infrastructure; Institution; Interdisciplinary Study; Intervention; Knowledge; Laboratories; Lead; Leadership; Lebanon; Malignant Childhood Neoplasm; Malignant Neoplasms; Medical center; Mission; Modality; Molecular; Molecular Target; Monitor; Multi-Institutional Clinical Trial; NCI Center for Cancer Research; National Cancer Institute; National Clinical Trials Network; New England; New Hampshire; Norris Cotton Cancer Center; Nursing Research; Oncology; Oncology Group; Operative Surgical Procedures; Patient Care; Patient Selection; Patients; Performance; Phase; Positioning Attribute; Preventive; Principal Investigator; Process; Protocols documentation; Radiation therapy; Randomized; Recording of previous events; Reporting; Request for Applications; Research; Research Personnel; Resource Sharing; Rural; Schools; Science; Scientist; Services; Site; Special Population; System; Target Populations; Testing; Therapeutic; Translating; Translational Research; Underserved Population; Vermont; anticancer research; cancer care; cancer clinical trial; cancer genomics; cancer imaging; cancer therapy; cancer type; clinical application; clinical translation; college; community based practice; design; innovation; interest; medical schools; medical specialties; member; multidisciplinary; multimodality; novel; operation; patient population; phase III trial; prevent; programs; rare cancer; response; screening; symposium; targeted treatment; treatment trial; tumor

Project Summary/Abstract Norris Cotton Cancer Center (NCCC), the keystone of the cancer-related activities of both Dartmouth College, including its Geisel School of Medicine, and Dartmouth-Hitchcock Health, will participate in the NCI's National Clinical Trials Network as a Lead Academic Participating Site. NCCC has a long history of leadership in national cooperative group clinical trials, dating back to serving as an operating center for CALGB, and more recently as a main member of the Alliance for Clinical Trial in Oncology, NRG, COG, and ECOG/ACRIN. As the only NCI- designated Comprehensive Cancer Center in northern New England, NCCC currently serves annually over 5,000 new patients and 30,000 returning cancer patients. NCCC is the specialty academic center for Vermont and New Hampshire, anchoring a network of 17 community-based practice sites across the region and receiving referrals of rare and advanced cancers, the target population for enrollment on innovative clinical trials, from a large geographic catchment area. Within Dartmouth, NCCC has a central Office of Clinical Research (OCR) which coordinates full participation in the entire range of available clinical trials. NCCC intends to participate fully in all NCTN activities, expanding its prior focus on participation in the Alliance. NCCC investigators are active in many NCTN Operations Center committees, facilitating a bi-directional integration of NCCC concepts into the NCTN, while NCTN studies will be seamless incorporated into the NCCC trial portfolio. We anticipate accrual of 55 consented subjects on high performance intervention for treatment trials and 20 subjects on screening only accruals for treatment or imaging trials. Care at DH is organized into 17 designated interdisciplinary disease-based teams which bring together all relevant specialties, 14 on a weekly basis, for new patient conferences at which eligibility for enrollment on clinical trials is assessed routinely. NCCC research nurses assigned to these Clinical Oncology Groups (COGs) are responsible for keeping the teams informed of available trials, and the NCCC clinical trials management system (Velos eResearch) provides the teams reports tracking current enrollment. While highest priority is given to translating NCCC science into clinical application, Dartmouth's size precludes most single-institution studies, and national cooperative group trials are prioritized ahead of industry-initiated studies for fulfillment of NCCC's clinical research mission.

项目总结/摘要 诺里斯棉花癌症中心（NCCC），两者的癌症相关活动的基石 达特茅斯学院，包括其盖泽尔医学院，和达特茅斯希区柯克健康， 将作为主要学术参与者参加NCI的国家临床试验网络 绝佳的价钱NCCC在国家合作组临床试验中有着悠久的领导历史， 回到作为CALGB的运营中心，最近又成为 肿瘤临床试验联盟、NRG、COG和ECOG/ACRIN。作为唯一的国家癌症研究所- 在北方新英格兰指定的综合癌症中心，NCCC目前服务 每年有超过5,000名新病人和30,000名返回的癌症病人。NCCC是专业的 佛蒙特州和新罕布什尔州的学术中心，锚定了17个社区为基础的网络 该地区的实践场所，并接受罕见和晚期癌症的转诊，目标是 从一个大的地理集水区招募创新临床试验的人口。 在达特茅斯，NCCC有一个临床研究的中央办公室（OCR），协调全面的 参与所有临床试验。NCCC打算充分参与所有 国家反恐网络的活动，扩大其先前对参与联盟的关注。NCCC研究者 积极参与许多NCTN运营中心委员会，促进双向整合 将NCCC概念纳入NCTN，而NCTN的研究将无缝纳入 NCCC试验组合。我们预计将有55名知情同意的高性能受试者 治疗试验的干预和20例筛选受试者仅累积治疗或 成像试验。卫生署的护理分为17个指定的跨学科疾病为基础的 每周14个小组，为新病人汇集所有相关专业 定期评估临床试验入组资格的会议。NCCC 分配到这些临床肿瘤组（COG）的研究护士负责 保持团队了解可用的试验，以及NCCC临床试验管理系统 （Velos eResearch）提供了跟踪当前注册的团队报告。虽然最高 优先考虑将NCCC科学转化为临床应用，达特茅斯的规模排除了 大多数单一机构研究和国家合作组试验优先于 行业发起的研究，以履行NCCC的临床研究使命。