Cell-cell communications create robust collective immunological responses

细胞间通讯产生强大的集体免疫反应

• 批准号: 9780029
• 负责人: Gregoire Altan-Bonnet
• 金额: $ 27.97万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9780029
• 关键词: Antigens; Antitumor Response; Autoantigens; CD4 Positive T Lymphocytes; CD8-Positive T-Lymphocytes; Cell Communication; Cell model; Cells; Cessation of life; Cues; Feedback; Frequencies; Goals; Heterogeneity; Immune response; Immunity; Individual; Interleukin-2; Laws; Output; Pathway interactions; Population; Predisposition; Production; Property; Reaction; Signal Transduction; Stimulus; T cell response; T-Cell Activation; T-Lymphocyte; Time; Tissues; Translating; Tumor Antigens; Work; Yang; analog; anti-tumor immune response; antigen-specific T cells; cytokine; exhaustion; paracrine; quantum; response; self organization; tool; tumor

We developed quantitative models of the cell-to-cell communications via cytokines amongst population of T lymphocytes. Our goal is to understand how T cells self-organize to decide their cell fate (e.g. between quiescence -tolerance- and death/proliferation -responses). At a fundamental level, we developed theoretical tools to analyze the heterogeneity and synchronicity of T cell responses in dense tissues. In the context of responses to tumor, we found that a critical mass of T cells existed to drive tumor rejection. Additional work is being carried out to dissect quantitatively how T cell decide collectively between tumor rejection and tumor tolerance.

我们通过细胞因子在T淋巴细胞群中建立了细胞间通讯的定量模型。我们的目标是了解T细胞如何自我组织来决定它们的细胞命运（例如，在沉默-耐受-和死亡/增殖-反应之间）。在基础水平上，我们开发了理论工具来分析致密组织中T细胞反应的异质性和同步性。在对肿瘤的反应中，我们发现存在临界质量的T细胞来驱动肿瘤排斥反应。更多的工作正在进行，以定量剖析T细胞如何在肿瘤排斥和肿瘤耐受之间共同决定。