Early Cognitive Impairment as a function of Alzheimer's Disease and Trauma
阿尔茨海默病和创伤导致的早期认知障碍
基本信息
- 批准号:10479319
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-01-01 至 2026-12-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAfricanAfrican AmericanAfrican ancestryAgeAge-associated memory impairmentAgingAlgorithmsAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAreaBenchmarkingBlood VesselsClinicalCognitiveCohort StudiesComplexComputerized Medical RecordCraniocerebral TraumaDataDementiaDevelopmentDiabetes MellitusDiagnosisDisparityEarly DiagnosisEnvironmentEnvironmental ExposureEnvironmental Risk FactorGenesGeneticGenetic DiseasesGenetic RiskGenomeGenomicsGenotypeHealthHispanicHispanic PopulationsHispanic ancestryImpaired cognitionIndividualInternational Classification of Disease CodesKnowledgeLate Onset Alzheimer DiseaseLinkMachine LearningMedical RecordsMethodsMilitary PersonnelNot Hispanic or LatinoParticipantPathologyPatient Self-ReportPatientsPerformancePhenotypePopulationPost-Traumatic Stress DisordersPrevalenceProxyPsychopathologyReportingResearch PriorityRiskRisk FactorsSensitivity and SpecificitySourceTechniquesToxinTraumaTraumatic Brain InjuryVariantVascular DementiaVeteransWorkagent orangebiobankcognitive testingcohortcombatcombat traumadementia riskdisorder riskeffective therapyfollow-upgene environment interactiongenetic analysisgenetic architecturegenetic associationgenetic risk factorgenetic variantgenome wide association studygenome-widehealth disparityimprovedmachine learning methodmild cognitive impairmentphenotyping algorithmpolygenic risk scoreprogramsrisk predictionrisk variantsymptomatology
项目摘要
Risk for dementia, including late-onset Alzheimer’s disease (AD) and vascular dementia, is
determined by a complex mix of environmental, health, and genetic factors. Veterans have
higher rates of vascular problems, PTSD, combat trauma, and traumatic brain injuries, which
have all been linked to increased rates of age-related cognitive impairment and dementia.
Further, studies have indicated that these Veteran-relevant exposures may interact with AD
genetics to further increase the risk of cognitive decline. This application represents an
outgrowth of a project examining dementia and combat related gene by environment (GxE)
interactions in the Million Veteran Program (MVP), one of the world’s largest electronic-medical
record (EMR) linked biobanks. The original 2-year MVP Gamma project (MVP015) generated
working definitions of mild cognitive impairment (MCI), AD, and all-cause dementia from the VA
EMR. These were examined for association with combat exposure, head injury, and PTSD in
aging Veterans. We found evidence that head injury, combat, PTSD symptomatology, and AD
genetic risk variants were all associated with self-reported cognitive difficulties and MCI in
Veterans as young as 45-55, and with AD and related dementias in those age 65+. We
additionally identified GxE interactions between candidate variants in several genes and
combat/head injury on MCI and AD risk. In this application, we propose expanding on the initial
study, by 1) performing a genome wide association study (GWAS) of Dementia cases and
controls in multiple ancestry groups as well as examining the performance of GWAS-based
genetic risk scores in African American and Hispanic MVP participants, 2) performing
multivariate GxE analyses examining a range of Veteran relevant health exposures, 3) Further
developing and validating dementia diagnoses in MVP for genetic analyses including a machine
learning based method of identification of Dementia cases. This project will expand on our
continuing work and increase our knowledge of the impact of Veteran specific environmental
exposures and their interactions with AD genes on risk for AD and dementia.
痴呆症的风险,包括晚发性阿尔茨海默病(AD)和血管性痴呆
项目成果
期刊论文数量(0)
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MARK W LOGUE其他文献
MARK W LOGUE的其他文献
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{{ truncateString('MARK W LOGUE', 18)}}的其他基金
Early Cognitive Impairment as a Function of Alzheimer’s Disease Genes and Trauma
阿尔茨海默病基因和创伤导致的早期认知障碍
- 批准号:
9899737 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Early Cognitive Impairment as a Function of Alzheimer’s Disease Genes and Trauma
阿尔茨海默病基因和创伤导致的早期认知障碍
- 批准号:
10683067 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Early Cognitive Impairment as a Function of Alzheimer’s Disease Genes and Trauma
阿尔茨海默病基因和创伤导致的早期认知障碍
- 批准号:
10795681 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Early Cognitive Impairment as a Function of Alzheimer’s Disease Genes and Trauma
阿尔茨海默病基因和创伤导致的早期认知障碍
- 批准号:
10355411 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Genomic Architecture of Functional Brain Networks in PTSD
创伤后应激障碍(PTSD)中功能性大脑网络的基因组结构
- 批准号:
10584246 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
创伤和基因组学调节常见精神疾病的大脑结构
- 批准号:
9389397 - 财政年份:2017
- 资助金额:
-- - 项目类别:
The impact of traumatic stress on the methylome: implications for PTSD
创伤应激对甲基化组的影响:对 PTSD 的影响
- 批准号:
9334946 - 财政年份:2016
- 资助金额:
-- - 项目类别:
The Impact of Traumatic Stress on the Methylome: implications for PTSD
创伤性应激对甲基组的影响:对 PTSD 的影响
- 批准号:
10414121 - 财政年份:2016
- 资助金额:
-- - 项目类别:
The impact of traumatic stress on the methylome: implications for PTSD
创伤应激对甲基化组的影响:对 PTSD 的影响
- 批准号:
9487032 - 财政年份:2016
- 资助金额:
-- - 项目类别:
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