Host Genetic and Epigenetic Factors of the Progression, Comorbidities and Outcomes of Viral Infection
Host Genetic and Epigenetic Factors of the Progression, Comorbidities and Outcomes of Viral Infection
批准号:
10485494
负责人:
Vincent Charles Marconi
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-10-01 至 2026-09-30
关键词:
2019-nCoVAccelerationAcuteAffectAgeAgingAlgorithmsAntiviral TherapyBiological AgingCOVID-19 impactChronicChronic DiseaseChronic Kidney FailureCommunicable DiseasesCongestive Heart FailureCoronary heart diseaseDNA MethylationDataDiabetes MellitusDiagnosticDiseaseDisease OutcomeDisease ProgressionElectronic Health RecordEpigenetic ProcessEthnic PopulationGeneral PopulationGeneticGenetic MarkersGenetic Predisposition to DiseaseHIVHIV InfectionsHealthHealthcare SystemsHeart failureHepatitis CHepatitis C virusHumanHuman GeneticsHuman GenomeImmuneImmune responseImmune systemImmunologicsIndividualInfectionInfectious AgentInflammatoryIntegration Host FactorsInterventionLife ExpectancyLinkLiver CirrhosisLiver FibrosisLongevityMeasurementMediationMendelian randomizationModelingModificationMolecularMorbidity - disease rateMultiomic DataOrganOutcomePathway interactionsPersonsPhenotypePopulation HeterogeneityPredispositionPreventionProcessPrognosisQuality of lifeRisk FactorsRoleSARS-CoV-2 infectionSample SizeSiteStrokeSystemTherapeuticVeteransVirus Diseasesadvanced analyticsage relatedchronic liver diseasecomorbiditydisorder riskepigenetic markerepigenome-wide association studiesgenetic variantgenome wide association studygenomic locushealthspanimprovedinsightlongitudinal analysismethylation biomarkermortalitymulti-ethnicmultiple chronic conditionsnovel markerpathogenprecision medicineprogramsresponse
中文摘要
病毒感染包括人类免疫缺陷病毒(HIV)、丙型肝炎病毒(HCV)
英文摘要
Viral infections including Human immunodeficiency virus (HIV), hepatitis C virus (HCV)
and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have placed a substantial
strain on human health and the health care system. These infections have specifically had broad
impacts on veteran health in the US. Host factors influence how humans respond to infectious
agents and develop adverse health outcomes after infection. Although previous genome-wide
association studies (GWAS) have identified loci associated with susceptibility and progression for
several infections, understanding the role of host genetic and epigenetic factors on chronic
disease comorbidities, aging, and long-term outcomes in the setting of viral infections has been
hampered by sample size, heterogeneous populations, and discordant measurements/definitions
of key phenotypes. Recent epigenome-wide association studies (EWAS) have uncovered DNA
methylation markers associated with noncommunicable diseases (NCDs, such as coronary heart
disease, diabetes, heart failure, chronic kidney disease), as well as HIV infection. However, the
epigenetic predictors for incident NCDs and mortality are largely unknown among people with
viral infections. Viral infections (e.g., HIV) can have a substantial impact on epigenetics, which
may affect long-term health outcomes. Additionally, acceleration of the epigenetic clock or age
has emerged as a novel biomarker of biological aging and can predict disease outcomes and
mortality. Therefore, we will systematically investigate genetic and epigenetic predictors of NCDs
and mortality in the following Aims. 1) To identify genetic and epigenetic predictors of age-related
morbidity and mortality as well as modification effect of HIV infection among multi-ethnic veterans;
2) To identify genetic and epigenetic factors associated with morbidity and mortality among multi-
ethnic veterans with HCV infection; 3) To identify genetic and epigenetic factors of long-term
comorbidities, accelerated aging and mortality, as well as mediation effect of COVID-19 among
multi-ethnic veterans.
Impact: Viral infections including HIV, HCV and SARS-CoV-2 broadly affects veteran’s
health and reduces the quality of life (healthspan) and life expectancy (lifespan) through a range
of comorbidities. The molecular mechanisms underlying the morbidity and mortality after viral
infections of HIV, HCV and SARS-CoV-2 are largely unknown. The proposed genetic and
epigenetic study can reveal the genetic and epigenetic factors linking viral infection (acute,
chronic, and resolved) and major NCD outcomes and mortality among multi-ethnic veterans, shed
lights on potential targets for new prevention and intervention, provide insights into the
comorbidity and aging process for all people, and develop systematic and precision medicine
strategies to improve veteran’s health.
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会议论文
Multi-omic Predictors of Renal Function among HIV-infected Individuals of African Ancestry
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批准号:10222667
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项目类别:
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资助金额:$70.89万
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财政年份:2020
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负责人:Vincent Charles Marconi
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依托单位:
Multi-omic Predictors of Renal Function among HIV-infected Individuals of African Ancestry
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批准号:10013809
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项目类别:
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资助金额:$70.53万
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财政年份:2020
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负责人:Vincent Charles Marconi
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依托单位:
Multi-omic Predictors of Renal Function among HIV-infected Individuals of African Ancestry
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批准号:10862088
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项目类别:
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资助金额:$33.55万
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财政年份:2020
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负责人:Vincent Charles Marconi
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依托单位:
Multi-omic Predictors of Renal Function among HIV-infected Individuals of African Ancestry
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批准号:10360539
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项目类别:
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资助金额:$70.96万
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财政年份:2020
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负责人:Vincent Charles Marconi
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依托单位:
Multi-omic Predictors of Renal Function among HIV-infected Individuals of African Ancestry
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批准号:10610370
-
项目类别:
-
资助金额:$77.12万
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财政年份:2020
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负责人:Vincent Charles Marconi
-
依托单位:
Multi-omic Predictors of Renal Function among HIV-infected Individuals of African Ancestry
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批准号:10818685
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项目类别:
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资助金额:$10.0万
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财政年份:2020
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负责人:Vincent Charles Marconi
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依托单位:
Effects of 12-weeks of High-intensity Resistance Aerobic Circuit Exercise Training on Epigenetic Aging and Inflammation in Older HIV-infected Veterans
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批准号:10382206
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项目类别:
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资助金额:$0.0万
-
财政年份:2019
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负责人:Vincent Charles Marconi
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依托单位:
Effects of 12-weeks of High-intensity Resistance Aerobic Circuit Exercise Training on Epigenetic Aging and Inflammation in Older HIV-infected Veterans
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批准号:10049196
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项目类别:
-
资助金额:$0.0万
-
财政年份:2019
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负责人:Vincent Charles Marconi
-
依托单位:
Effects of 12-weeks of High-intensity Resistance Aerobic Circuit Exercise Training on Epigenetic Aging and Inflammation in Older HIV-infected Veterans
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批准号:10710375
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项目类别:
-
资助金额:$0.0万
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财政年份:2019
-
负责人:Vincent Charles Marconi
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依托单位:
Central memory CD4 T cell infection: key role in ART response and HIV persistence
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批准号:8738608
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项目类别:
-
资助金额:$89.5万
-
财政年份:2013
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负责人:Vincent Charles Marconi
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依托单位:
Central memory CD4 T cell infection: key role in ART response and HIV persistence
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批准号:8659897
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项目类别:
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资助金额:$87.36万
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财政年份:2013
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负责人:Vincent Charles Marconi
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依托单位:
Central memory CD4 T cell infection: key role in ART response and HIV persistence
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批准号:8899430
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项目类别:
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资助金额:$88.17万
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财政年份:2013
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负责人:Vincent Charles Marconi
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依托单位:
Central memory CD4 T cell infection: key role in ART response and HIV persistence
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批准号:9124732
-
项目类别:
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资助金额:$86.91万
-
财政年份:2013
-
负责人:Vincent Charles Marconi
-
依托单位:
Central memory CD4 T cell infection: key role in ART response and HIV persistence
-
批准号:9330766
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项目类别:
-
资助金额:$85.4万
-
财政年份:2013
-
负责人:Vincent Charles Marconi
-
依托单位:
海外基金