Integrated Health Science Facility Core

综合健康科学设施核心

• 批准号: 10600122
• 负责人: Matthew C Cave
• 金额: $ 13.74万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10600122
• 关键词: Adult; Affect; Basic Science; Biological; Biological Markers; Biometry; Charge; Charities; Childhood; Chronic Disease; Clinical; Clinical Research; Clinical Trials; Clinical Trials Unit; Communities; Consent; Consultations; Core Facility; Data; Data Analyses; Development; Disease; Doctor of Medicine; Early Diagnosis; Ensure; Environment; Environmental Health; Evaluation; Fee-for-Service Plans; Goals; Health; Health Sciences; Health Services Accessibility; Human; Human Resources; Human Subject Research; Informatics; Infrastructure; Interdisciplinary Study; Interest Group; Intervention; Knowledge; Life; Measurement; Measures; Metagenomics; Metals; National Institute of Environmental Health Sciences; Nature; Performance; Pharmaceutical Preparations; Physicians; Pilot Projects; Pollution; Population Research; Prevention; Program Evaluation; Proteomics; Public Health Practice; Randomized; Reporting; Research; Research Design; Research Personnel; Research Support; Retrieval; Sampling; Scientist; Services; Technology; Therapeutic Intervention; Time; Training and Education; Translating; Translational Research; Universities; biobank; clinical practice; cohort; community engagement; community involvement; community organizations; cost effective; design; experience; follow-up; human data; human subject; improved; innovation; instrument; instrumentation; interest; lifestyle factors; member; metabolomics; multidisciplinary; patient oriented; programs; recruit; response; sample collection; sex; transcriptomics; volatile organic compound

The overarching objective of the Integrated Health Sciences Facility Core (IHSFC) of the Center for Integrated Environmental Health Sciences (CIEHS) is to translate basic research on pollution and lifestyle factors influencing human health and chronic diseases. The multi-disciplinary IHSFC provides infrastructure facilitating translational human subjects EHS research for the CIEHS, university, and community. The ultimate goal is to improve public health and clinical practice. The IHSFC supports patient-oriented clinical research; group and population-based research; and community engaged/led research. The IHSFC is comprised of two interacting subunits: the Research Administration and Planning Subunit (RAPS) and the Research Implementation Subunit (RIS). The IHSFC interacts with other CIEHS cores and the Research Interest Groups (RIGs) to (i) provide access to state-of-the-art instrumentation and technologies; (ii) increase multidisciplinary collaboration; and (iii) enhance partnerships with community-based organizations. The IHSFC’s first specific aim is to administer the IHSFC and plan translational human subjects EHS research. This aim is performed by RAPS. RAPS provides IHSFC access to CIEHS members, trainees, and the community. RAPS solicits applications for human subjects research; and then reviews, prioritizes and financially subsidizes supported applications. RAPS defines IHSFC research in the context of the NIEHS Translational Research Framework. Community- proposed research ideas are assigned to an appropriate CIEHS member for development and execution. RAPS provides translational research training/education; and tracks and reports performance metrics to the Administrative Core for evaluation. RAPS provides scientific, study design, and community engagement consultation through linkages to the RIGs and other CIEHS cores. These consultations ensure that all IHSFC- supported studies: (i) are rigorously designed and powered; (ii) are consistent with CIEHS’s theme and research interests; and (iii) consider the involvement of community organizations impacting this research. The IHSFC’s second specific aim is to implement IHSFC research. This aim is performed by the RIS. RIS provides human subjects research services and access to state-of-the-art bio-analytic instrumentation and technologies through linkage to the Integrated Toxicomics & Environmental Measurement Facility Core (ITEMFC). In turn, ITEMFC measures exposure and ‘omics-based disease biomarkers. RIS leverages UofL’s adult Clinical Trials Unit (CTU), the Kosair Charities Pediatric Clinical Research Units (KCPCRU), and existing cohorts/biorepositories to obtain human subjects data and biological samples. Next, RIS provides linkage to other CIEHS cores for biomarker measurement, data analysis, and knowledge dissemination. Based on the combination of physician-scientists engaged in EHS research and clinical research units found nowhere else, the IHSFC has the unique capacity to conduct impactful translational EHS research, including biomarker studies and interventional clinical trials.

综合健康科学中心综合健康科学设施核心（IHSFC）的总体目标 环境健康科学（CIEHS）旨在转化污染和生活方式因素的基础研究 影响人类健康和慢性疾病。多学科 IHSFC 提供基础设施促进 针对 CIEHS、大学和社区的转化人类主题 EHS 研究。最终目标是 改善公共卫生和临床实践。 IHSFC 支持以患者为导向的临床研究；组和 以人群为基础的研究；和社区参与/主导的研究。 IHSFC 由两个相互作用的 下属单位：研究管理和规划下属单位（RAPS）和研究实施 亚基（RIS）。 IHSFC 与其他 CIEHS 核心和研究兴趣小组 (RIG) 互动，以 (i) 提供最先进的仪器和技术； (ii) 加强多学科合作； (iii) 加强与社区组织的伙伴关系。 IHSFC 的第一个具体目标是 管理 IHSFC 并计划转化人类受试者 EHS 研究。该目标由 RAPS 执行。 RAPS 为 IHSFC 提供了接触 CIEHS 成员、学员和社区的机会。 RAPS 征集申请 人类受试者研究；然后对支持的应用程序进行审查、优先排序并提供经济补贴。 RAPS 在 NIEHS 转化研究框架的背景下定义了 IHSFC 研究。社区- 提出的研究想法将分配给适当的 CIEHS 成员进行开发和执行。 RAPS 提供转化研究培训/教育；并跟踪绩效指标并将其报告给 评估的行政核心。 RAPS 提供科学、研究设计和社区参与 通过与 RIG 和其他 CIEHS 核心的联系进行协商。这些磋商确保所有 IHSFC- 支持的研究：(i) 经过严格设计和支持； (ii) 符合CIEHS的主题，并且 研究兴趣； (iii) 考虑影响这项研究的社区组织的参与。这 IHSFC 的第二个具体目标是实施 IHSFC 研究。这一目标由 RIS 来实现。 RIS 提供 人类受试者研究服务以及最先进的生物分析仪器和技术 通过与综合毒理学和环境测量设施核心（ITEMFC）的链接。反过来， ITEMFC 测量暴露和“基于组学的疾病生物标志物”。 RIS 利用 UofL 的成人临床试验 单位 (CTU)、Kosair 慈善儿科临床研究单位 (KCPCRU) 以及现有的 队列/生物样本库来获取人类受试者数据和生物样本。接下来，RIS 提供链接 其他用于生物标志物测量、数据分析和知识传播的 CIEHS 核心。基于 从事 EHS 研究和临床研究单位的医师科学家组合是其他地方找不到的， IHSFC 拥有开展有影响力的转化 EHS 研究的独特能力，包括生物标志物 研究和介入临床试验。