Repository Core

存储库核心

• 批准号: 10489297
• 负责人: LEE-WAY JIN
• 金额: $ 391.23万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10489297
• 关键词: 3-Dimensional; Affect; Alzheimer' s Disease; Alzheimer’s disease biomarker; Amyloid beta-42; Anatomy; Bar Codes; Biological; Biological Markers; Blood; Blood specimen; Brain Injuries; Categories; Clinic; Clinical; Clinical Data; Cognitive; Collaborations; Collection; Communities; DNA; Data; Data Set; Databases; Dementia; Deposition; Derivation procedure; Ensure; Equipment and supply inventories; Freezing; Future; Genetic; Genetic Predisposition to Disease; Genotype; Glial Fibrillary Acidic Protein; Goals; IL18 gene; Impaired cognition; Individual; Inflammation; Inflammatory; Infrastructure; Leadership; Lesion; Light; Liquid substance; Location; Longitudinal Studies; Machine Learning; Magnetic Resonance Imaging; Measures; Mission; NOTCH3 gene; National Institute of Neurological Disorders and Stroke; Nerve Degeneration; Pathology; Pathway interactions; Phenotype; Plasma; Population; Population Heterogeneity; Procedures; Process; Protocols documentation; Qualifying; Quality Control; Recommendation; Regulation; Reproducibility of Results; Research; Research Personnel; Research Support; Resource Sharing; Resources; Retrieval; Risk; Role; Sampling; Secure; Services; Shipping; Site; Specimen; Standardization; System; Therapeutic; Time; Validation; Variant; White Matter Hyperintensity; Work; apolipoprotein E-4; biomarker discovery; clinical research site; clinically significant; comorbidity; cost efficient; data integrity; data sharing; endothelial dysfunction; exome sequencing; experience; genome-wide; interest; neurofilament; neuroimaging; novel marker; polygenic risk score; precision medicine; programs; recruit; repository; risk prediction model; standardize measure; synergism; tau Proteins; vascular risk factor; white matter; white matter injury

PROJECT SUMMARY – Repository Core The overarching goal of the Clinical significance of INciDEntal white matter lEsions on MRI in a Diverse population with cognitive complaints (INDEED) is to identify anatomic and biologic modulators of progressive white matter (WM) injury that drive cognitive impairment using a precision medicine approach in a large and diverse clinical population. To achieve this goal, three essential biological datasets will be acquired: 1) harmonized neuroimaging data to document the degree, location, and amount of WM injury; 2) fluid biomarker data to evaluate risk modifiers including inflammation, endothelial dysfunction, and co-morbid neurodegenerative conditions; and 3) genetic data to measure intrinsic genetic susceptibility using polygenic risk scores for Alzheimer's disease (AD) and WM hyperintensities (WMH) and known sequence variants (e.g. APOE4 and NOTCH3). The goal of the Repository Core (RC), therefore, is to use harmonized approaches to collect, process, store, track, analyze, and share neuroimaging, biospecimens and associated genetic data. Centralized core services are needed to effectively support the research mission and enable the scientific synergy necessary for a project of this scale, in which samples and data will be obtained from 2,250 diverse subjects nationwide at three time points, for a total of up to 6,750 data/sample sets. Collecting data/samples from multiple sites over 5 years will require standardized quality control (QC) checks, data tracking, and coordination with research staff at participating clinic sites. The RC, with its leadership and investigators experienced in managing similar tasks in the NINDS MarkVCID Consortium and ADRC Cores, will provide the technical, professional, and physical infrastructure to effectively implement the core mission by executing four specific aims. In Aim 1, the RC will work with NINDS, the Administrative Core (AC), and the collaborating clinic sites to develop and implement standardized operating procedures for blood collection, processing, sub- aliquoting, freezing, shipping, long-term storage, and distribution, by leveraging the existing AD Centers Program, MarkVCID Consortium, and DISCOVERY Network protocols. In Aim 2, we will generate, store, analyze, and distribute blood biomarker and genetic data relevant to WM injury and co-morbid neurodegenerative pathologies. In Aim 3, we will oversee acquisition, analysis, QC, and distribution of harmonized neuroimaging data that will directly inform the rate of progression and anatomic features of WM injury to their role in cognitive impairment. In Aim 4, we will work with the AC and the Statistical Core to export data and sample information, thus contributing to the sharing of data and specimens broadly with the research community. The RC will ensure consistent integrity of data and samples that will deliver a high level of scientific rigor and the reproducibility of results. The deposited data and biospecimens will create a rich and high-quality resource for future analyses, novel biomarker discovery, and identification of therapeutically significant pathways that underlie the contribution of WM injury to cognitive decline and dementia.

项目摘要-仓库核心