Brain-wide circuits for drug-induced changes to cognition
药物引起的认知变化的全脑回路
基本信息
- 批准号:10494006
- 负责人:
- 金额:$ 30.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-01 至 2028-05-31
- 项目状态:未结题
- 来源:
- 关键词:AcuteAnimalsBehaviorBehavioralBrainBrain regionCell NucleusCodeCognitionCognitiveComplexDissociationDrug AddictionDrug usageElectrophysiology (science)EnvironmentGeneticHCN1 channelHCN1 geneHippocampusImpairmentKetamineKnock-outKnockout MiceLeftLinkLocationLong-Term EffectsMeasuresMedialMemoryMethamphetamineMolecularMolecular TargetMorphineMovementMusNR2A NMDA receptorNatureNeuronsParietalPersonsPharmaceutical PreparationsPhysiologicalPositioning AttributePrevalencePropertyRelapseRewardsRunningSiteSpace PerceptionSpeedSystemTechniquesTechnologyTherapeuticTherapeutic AgentsTrainingUpdateViralVisualWorkbrain behaviorcognitive processdrug actiondrug of abusedrug seeking behaviorentorhinal cortexexperiencehypnoticin vivoinsightinterestneuralneural circuitneural correlateoperationpsychologicresponsespatial memoryvirtual reality environmentway finding
项目摘要
PROJECT SUMMARY (Project 2)
Dissociative and non-dissociative drugs, such as ketamine, PCP, methamphetamine and morphine, exert
powerful psychological effects by inducing profoundly altered brain states. The popularity of these drugs, their
psychologically and physiologically addictive nature and the rising prevalence of a subclass of dissociative drugs
as potential therapeutic agents indicate an urgent need to understand the acute and long-term effects of these
drugs on brain-states. A large gap exists however, in our understanding of the circuit mechanisms underlying
drug-altered states themselves. To bridge this gap, we seek to elucidate the molecular, circuit and network
mechanisms of drug induced cognitive states by taking advantage of a set of highly tractable response properties
of neurons across the multiple brain regions that support spatial cognition. Our focus on spatial cognition is
motivated by the shared capability of dissociative and non-dissociative drugs to alter neural representations of
space. Dissociative drugs are well documented to induce out-of-body experiences and can impair spatial
memory. Non-dissociative drugs of abuse can leverage the spatial memory system to encode drug-context
associations, leading to drug-associated contexts serving as a potent trigger for relapse to drug use. However,
the brain-wide circuit mechanisms underlying these alterations in spatial cognition, as well as how this impacts
behavior, remain incompletely understood. Here, we use cutting-edge large scale in vivo electrophysiology
combine with behavioral techniques to examine the link between drug-induced spatial cognitive effects and the
microcircuits of spatial and memory coding. First, we perform wide-scale electrophysiology to measure the
neural correlates of spatial estimates in multiple cortical and sub-cortical brain regions during navigation to
investigate how dissociative and non-dissociative drugs induce changes in spatial cognition. Next, we hone in
on particular brain regions of interest in freely moving animals to examine how dissociative and non-dissociative
drugs drive changes in the neural correlates of behavior in spatial tasks. Finally, in vivo electrophysiology is
combined with genetic and behavioral approaches to parse out the molecular basis of ketamine’s potentially
therapeutic versus negative effects on spatial cognition. Together, this work will provide new insight regarding
the brain wide-circuit mechanisms for cognitive states associated with drugs of addiction and the behavioral
impacts of these drug-induced cognitive states on spatial memory and navigational behavior.
.
项目总结(项目2)
解离和非解离药物,如氯胺酮、五氯苯酚、甲基苯丙胺和吗啡,对
通过诱导大脑状态的深刻改变而产生强大的心理效应。这些药物的受欢迎程度,他们的
心理和生理上瘾的性质和一类解离药物的日益流行
由于潜在的治疗药物表明迫切需要了解这些药物的急性和长期影响
药物对大脑状态的影响。然而,在我们对潜在的电路机制的理解中存在着很大的差距
药物改变的状态本身。为了弥补这一鸿沟,我们试图阐明分子、电路和网络
药物诱发认知状态的机制--利用一组高度易处理的反应特性
支持空间认知的多个大脑区域的神经元。我们对空间认知的关注是
受解离和非解离药物改变神经表征的共同能力的推动
太空。有充分的证据表明,解离药物会导致体外体验,并可能损害空间
记忆。非解离性滥用药物可以利用空间记忆系统来编码药物上下文
这种联系导致与毒品有关的环境成为吸毒复发的有力诱因。然而,
这些空间认知变化背后的全脑回路机制,以及这种变化如何影响
行为,仍然没有完全被理解。在这里,我们使用了最先进的大规模活体电生理学
结合行为技术检查药物诱导的空间认知效应和
空间编码和记忆编码的微电路。首先,我们进行大范围的电生理来测量
在导航到期间多个皮质和皮质下脑区空间估计的神经相关性
研究解离和非解离药物如何导致空间认知的变化。接下来,我们来磨练
在自由活动动物的特定大脑感兴趣区域上检查如何分离和非分离
药物会导致空间任务中行为的神经关联发生变化。最后,活体电生理学是
结合遗传和行为方法解析氯胺酮潜在的分子基础
治疗效果与对空间认知的负面影响。总之,这项工作将为以下方面提供新的见解
药物成瘾相关认知状态的脑广路机制及行为
这些药物诱导的认知状态对空间记忆和导航行为的影响。
。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Lisa Giocomo其他文献
Lisa Giocomo的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Lisa Giocomo', 18)}}的其他基金
The Dynamics of Neural Representations for Distinct Spatial Contexts and Memory Episodes
不同空间背景和记忆片段的神经表征的动力学
- 批准号:
10620709 - 财政年份:2022
- 资助金额:
$ 30.13万 - 项目类别:
The Dynamics of Neural Representations for Distinct Spatial Contexts and Memory Episodes
不同空间背景和记忆片段的神经表征的动力学
- 批准号:
10435250 - 财政年份:2022
- 资助金额:
$ 30.13万 - 项目类别:
Mesh electronics for understanding space encoding in the amphibian brain
用于理解两栖动物大脑空间编码的网状电子器件
- 批准号:
10446284 - 财政年份:2022
- 资助金额:
$ 30.13万 - 项目类别:
Research Project 4 - Internal state dynamics of navigation and memory
研究项目4 - 导航和记忆的内部状态动力学
- 批准号:
10687148 - 财政年份:2021
- 资助金额:
$ 30.13万 - 项目类别:
Research Project 4 - Internal state dynamics of navigation and memory
研究项目4 - 导航和记忆的内部状态动力学
- 批准号:
10490244 - 财政年份:2021
- 资助金额:
$ 30.13万 - 项目类别:
Research Project 4 - Internal state dynamics of navigation and memory
研究项目4 - 导航和记忆的内部状态动力学
- 批准号:
10047735 - 财政年份:2021
- 资助金额:
$ 30.13万 - 项目类别:
The Ionic Basis of Spatial Codes in Medial Entorhinal Cortex
内侧内嗅皮层空间编码的离子基础
- 批准号:
9321962 - 财政年份:2015
- 资助金额:
$ 30.13万 - 项目类别:
Spatial Codes Across the Medial Entorhinal Cortex for Memory and Navigation
内侧内嗅皮层用于记忆和导航的空间代码
- 批准号:
10120754 - 财政年份:2015
- 资助金额:
$ 30.13万 - 项目类别:
相似海外基金
CAREER: Next-generation of Wirelessly Powered Implantable Neuromodulation and Electrophysiological Recording System for Long-term Behavior Study of Freely-Moving Animals
职业:下一代无线供电植入式神经调节和电生理记录系统,用于自由移动动物的长期行为研究
- 批准号:
2309413 - 财政年份:2022
- 资助金额:
$ 30.13万 - 项目类别:
Continuing Grant
Developing remote monitoring system of aquatic animals' behavior and ecology to reform ecosystem conservation
开发水生动物行为和生态远程监测系统改革生态系统保护
- 批准号:
22K18432 - 财政年份:2022
- 资助金额:
$ 30.13万 - 项目类别:
Grant-in-Aid for Challenging Research (Pioneering)
OCE-PRF: Cliff Hangers: Investigating Effects of a Submarine Canyon on the Distribution and Behavior of Midwater Animals and their Predators
OCE-PRF:悬崖吊架:调查海底峡谷对中层水域动物及其捕食者的分布和行为的影响
- 批准号:
2126537 - 财政年份:2021
- 资助金额:
$ 30.13万 - 项目类别:
Standard Grant
CAREER: Next-generation of Wirelessly Powered Implantable Neuromodulation and Electrophysiological Recording System for Long-term Behavior Study of Freely-Moving Animals
职业:下一代无线供电植入式神经调节和电生理记录系统,用于自由移动动物的长期行为研究
- 批准号:
1943990 - 财政年份:2020
- 资助金额:
$ 30.13万 - 项目类别:
Continuing Grant
Study on factors that increase or decrease the vigilance behavior of wild animals: the effect of species differences and visual stimuli
野生动物警觉行为增减因素研究:物种差异和视觉刺激的影响
- 批准号:
20K06353 - 财政年份:2020
- 资助金额:
$ 30.13万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Neural circuit underlying flexible behavior in animals
动物灵活行为的神经回路
- 批准号:
19H01769 - 财政年份:2019
- 资助金额:
$ 30.13万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Analysis of adaptive mechanisms in chemical localization behavior of animals by using novel devices to intervene in sensory and motor functions
使用新型装置干预感觉和运动功能来分析动物化学定位行为的适应性机制
- 批准号:
19H02104 - 财政年份:2019
- 资助金额:
$ 30.13万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Life Cost Strategy for Wild Animals Using Wearable Behavior Recording Devices and Telomere Measurement
使用可穿戴行为记录设备和端粒测量的野生动物生命成本策略
- 批准号:
18K14788 - 财政年份:2018
- 资助金额:
$ 30.13万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Modeling and application of energy-efficient behavior in calling animals
动物呼叫节能行为建模及应用
- 批准号:
18K18005 - 财政年份:2018
- 资助金额:
$ 30.13万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Cooperative behavior of non-human animals focusing on reward sharing -comparison between rodents and birds-
注重奖励分享的非人类动物的合作行为-啮齿类动物与鸟类的比较-
- 批准号:
18K12020 - 财政年份:2018
- 资助金额:
$ 30.13万 - 项目类别:
Grant-in-Aid for Scientific Research (C)