课题基金 / 基金详情

Mechanisms promoting the transition to invasive cancer

Mechanisms promoting the transition to invasive cancer
促进向侵袭性癌症转变的机制
批准号:
9674952
负责人:
Heather L Machado
金额:
$9.61万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-01 至 2021-08-31

项目摘要

项目成果

Heather L Machado的其他基金

相似基金

相关文献

中文摘要
翻译
项目总结
英文摘要
PROJECT SUMMARY Clinical and epidemiological evidence suggests that ~40% of patients with ductal carcinoma in situ (DCIS) left untreated will progress to invasive breast cancer. However, due to our inability to distinguish lesions that will progress to invasive cancer from those that will remain non-invasive indefinitely, all DCIS patients are treated with surgery with or without radiation. Unfortunately, very little is known about how pre-invasive DCIS cells acquire the ability to invade the adjacent stroma, and how the stroma influences localized invasion has not been studied. The proposed studies aim to define the molecular interactions between infiltrating macrophages and pre-invasive epithelial cells, and uncover the mechanisms that promote tumor development in early stage lesions. The central hypothesis is that distinct macrophage populations promote the transition to invasive cancer and that Axl-mediated invasion is dependent on the transcription factor C/EBPβ. This hypothesis will be tested by the following aims: Aim 1: To track macrophages in vivo during the transition from pre-invasive to invasive cancer. Aim 2: To characterize macrophage heterogeneity in early stage lesions. Aim 3: To determine whether C/EBPβ-induced Axl in pre-invasive cells is required for localized invasion in early stage lesions. Our studies will utilize several mouse models and 2-photon microscopy to uncover the mechanism of localized invasion. Significance: The proposed studies will identify a mechanism by which DCIS cells proliferate and/or invade the basement membrane, and define how the stroma promotes progression to invasive cancer, addressing major knowledge gaps in the field of premalignancy.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Functions of ductal- and stromal-associated macrophages in the mammary gland
  • 批准号:
    10700123
  • 项目类别:
  • 资助金额:
    $48.44万
  • 财政年份:
    2022
  • 负责人:
    Heather L Machado
  • 依托单位:
Kinase signaling during mammary tumor initiation
  • 批准号:
    9751809
  • 项目类别:
  • 资助金额:
    $25.68万
  • 财政年份:
    2017
  • 负责人:
    Heather L Machado
  • 依托单位:
Kinase signaling during mammary tumor initiation
  • 批准号:
    9445042
  • 项目类别:
  • 资助金额:
    $34.43万
  • 财政年份:
    2017
  • 负责人:
    Heather L Machado
  • 依托单位:
Kinase signaling during mammary tumor initiation
  • 批准号:
    10242663
  • 项目类别:
  • 资助金额:
    $34.43万
  • 财政年份:
    2017
  • 负责人:
    Heather L Machado
  • 依托单位:
海外基金