Advancing Clinical Science in Pediatric Gastroparesis
推进小儿胃轻瘫的临床科学
基本信息
- 批准号:9554886
- 负责人:
- 金额:$ 36.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-25 至 2021-08-31
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAdultAffectAgeBiopsyBreath TestsCharacteristicsChildChildhoodClinicalClinical SciencesCognitiveCollaborationsCommunitiesComorbidityDNADataDiabetes MellitusDiagnosisDiagnosticDiseaseDyspepsiaEpidemiologyEpigastriumEquipment and supply inventoriesEthnic OriginEtiologyFecesFemale AdolescentsFutureGastric EmptyingGastrointestinal EndoscopyGastroparesisGenderGeneral PopulationGeneric DrugsGoalsHospitalizationHuman MicrobiomeIncidenceInterventionInterviewKnowledgeMeasuresMechanicsMorbidity - disease rateMucous MembraneNatural HistoryNatureNauseaNormal RangeNutritionalObstructionOperative Surgical ProceduresOutcome MeasurePainPatient Outcomes AssessmentsPatientsPediatricsPopulationPrevalenceQuality of lifeRaceRadioactiveRadionuclide ImagingRegistriesResearchRoleSerumSolidSpirulina preparationStomachSymptomsTherapeuticTimeTranslationsVomitingWomanage relatedbasebiobankboyscommon symptomcytokinedesignearly satietygastrointestinalgastrointestinal symptomgirlshealth related quality of lifeimproved outcomeinfancyinnovationinsightinterdisciplinary approachmicrobiomemortalitynovelprospectivepsychologic
项目摘要
Gastroparesis (GP) in children and adults is characterized by delayed gastric emptying in the absence of
mechanical obstruction. GP is associated with significant morbidity and mortality yet little is known regarding its
incidence, prevalence, and natural history, particularly in children. This knowledge gap in pediatric GP is
exacerbated by lack of both normative data for gastric emptying and a GP specific patient reported outcome
measure. The limited data suggest significant differences between clinical symptoms of GP in children vs adults.
Thus, even the limited data regarding GP in adults are unlikely to provide insight and fill the knowledge gaps
regarding GP in children. These issues (among others) underscore the need for childhood GP specific research
strategies rather than translation of adult based GP knowledge to this very different population.
To begin to identify effective diagnostic and therapeutic strategies leading to improved outcomes for children
with GP given the vast knowledge gaps in the field, we propose the following Specific Aims within a prospective,
multiinstitutional collaboration:
1) Using the 13C-Spirulina breath test (BT) (which correlates well with gastric scintigraphy) define normal
values for solid meal emptying in (n=260) healthy controls (HC) (5-18 yrs. of age). Sub-Aim: carry out the BT in
children (n=420, 5-18 yrs. of age) with presumed GP who are undergoing gastric scintigraphy to identify children
who truly have GP as defined by the normal values obtained in HC.
2) In children undergoing gastric scintigraphy in (Sub) Aim 1, determine the feasibility, reliability, and validity
of generic and gastrointestinal (GI)-specific health-related quality of life using the Pediatric Quality of Life
Inventory (PedsQL) Generic Core Scales and PedsQL GI Symptoms Scales and PedsQL GI Worry Scales. Sub-
Aim 2A: Use the scales to differentiate patients with GP vs. age, gender, and race/ethnicity matched children
with functional dyspepsia (whose symptoms often overlap with GP) and HC; Sub-Aim 2B: Use the GI scales and
cognitive interviews to create a pediatric GP-specific health-related quality of life measure.
3) Create a national prospective: (a) Registry of children and adolescents with GP to include demographic,
clinical, psychological, and nutritional characteristics and (b) Biorepository of serum, GI mucosal biopsies (in
those undergoing upper GI endoscopy), and stool for future analyses such as DNA, cytokines, microbiome.
This multidisciplinary approach is innovative as it will, for the first time, prospectively begin to fill the vast
knowledge void regarding GP in children. These data will be an important step toward targeted and pediatric-
friendly interventions for children with GP. This project also will be a first step to developing a national pediatric
consortium to investigate GP in children. The current proposal fits RFA-DK-16-010 to, among other goals, better
understand the epidemiology of GP, define the GP/FD spectrum, explore and design new patient reported
outcomes, and the role of the human microbiome on disease expression.
胃轻瘫(GP)在儿童和成人的特点是延迟胃排空在缺席
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert J Shulman其他文献
IN VITRO UTILIZATION OF LACTOSE BY THE FECAL FLORA DIFFERS IN BREAST-(BR) AND BOTTLE-FED (BO) INFANTS
体外粪便菌群对乳糖的利用在母乳喂养(BR)和配方奶喂养(BO)婴儿中有所不同
- DOI:
10.1203/00006450-198704010-00630 - 发表时间:
1987-04-01 - 期刊:
- 影响因子:3.100
- 作者:
Carlos H Liischitz;May Chen;Robert J Shulman;Meyer Wolin;Buford L Nichols - 通讯作者:
Buford L Nichols
EFFECT OF FEEDING REGIMEN AND AMBIENT LIGHT EXPOSURE PATTERNS ON WEIGHT GAIN IN THE NEONATAL PIG. † 1873
- DOI:
10.1203/00006450-199604001-01897 - 发表时间:
1996-04-01 - 期刊:
- 影响因子:3.100
- 作者:
Lynn J Lotas;Robert J Shulman - 通讯作者:
Robert J Shulman
Mechanisms of Disease: update on the molecular etiology and fundamentals of parenteral nutrition associated cholestasis
疾病机制:肠外营养相关性胆汁淤积的分子病因学和基础研究的最新进展
- DOI:
10.1038/ncpgasthep0796 - 发表时间:
2007-05-01 - 期刊:
- 影响因子:51.000
- 作者:
Beth A Carter;Robert J Shulman - 通讯作者:
Robert J Shulman
The Addition of Human Milk Fortifier Does Not Affect Feeding Tolerance in Premature Infants † 1552
添加母乳强化剂不影响早产儿的喂养耐受性†1552
- DOI:
10.1203/00006450-199804001-01574 - 发表时间:
1998-04-01 - 期刊:
- 影响因子:3.100
- 作者:
Gloria J Moody;Richard J Schanler;Robert J Shulman;Chantal Lau - 通讯作者:
Chantal Lau
DEVELOPMENT OF HEPATIC N-DEMETHYLASE ACTIVITY AS MEASURED IN VIVO BY THE AMINOPYRINE BREATH TEST
通过氨基比林呼气试验在体内测量肝 N-去甲基酶活性的发展
- DOI:
10.1203/00006450-198404001-00404 - 发表时间:
1984-04-01 - 期刊:
- 影响因子:3.100
- 作者:
Robert J Shulman;Charles S Irving;Thomas W Boutton;William W Wong;Buford L Nichols;Peter D Klein - 通讯作者:
Peter D Klein
Robert J Shulman的其他文献
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{{ truncateString('Robert J Shulman', 18)}}的其他基金
Peppermint Oil Pharmacokinetics/Dynamics and Novel Biological Signatures in Children with Functional Abdominal Pain
功能性腹痛儿童的薄荷油药代动力学/动力学和新的生物特征
- 批准号:
10001107 - 财政年份:2019
- 资助金额:
$ 36.12万 - 项目类别:
Peppermint Oil Pharmacokinetics/Dynamics and Novel Biological Signatures in Children with Functional Abdominal Pain
功能性腹痛儿童的薄荷油药代动力学/动力学和新的生物特征
- 批准号:
10242085 - 财政年份:2019
- 资助金额:
$ 36.12万 - 项目类别:
Peppermint Oil Pharmacokinetics/Dynamics and Novel Biological Signatures in Children with Functional Abdominal Pain
功能性腹痛儿童的薄荷油药代动力学/动力学和新的生物特征
- 批准号:
10015202 - 财政年份:2019
- 资助金额:
$ 36.12万 - 项目类别:
Advancing Clinical Science in Pediatric Gastroparesis
推进小儿胃轻瘫的临床科学
- 批准号:
9564280 - 财政年份:2016
- 资助金额:
$ 36.12万 - 项目类别:
Peppermint Oil Pharmacokinetics/Dynamics and Novel Biological Signatures in Children with Functional Abdominal Pain
功能性腹痛儿童的薄荷油药代动力学/动力学和新的生物特征
- 批准号:
9346618 - 财政年份:2016
- 资助金额:
$ 36.12万 - 项目类别:
Advancing Clinical Science in Pediatric Gastroparesis
推进小儿胃轻瘫的临床科学
- 批准号:
10001460 - 财政年份:2016
- 资助金额:
$ 36.12万 - 项目类别:
Peppermint Oil Pharmacokinetics/Dynamics and Novel Biological Signatures in Children with Functional Abdominal Pain
功能性腹痛儿童的薄荷油药代动力学/动力学和新的生物特征
- 批准号:
9096507 - 财政年份:2016
- 资助金额:
$ 36.12万 - 项目类别:
Genetic Analysis of Carbohydrate Maldigestion in Irritable Bowel Syndrome
肠易激综合征碳水化合物消化不良的遗传分析
- 批准号:
8901156 - 财政年份:2014
- 资助金额:
$ 36.12万 - 项目类别:
Genetic Analysis of Carbohydrate Maldigestion in Irritable Bowel Syndrome
肠易激综合征碳水化合物消化不良的遗传分析
- 批准号:
8701693 - 财政年份:2014
- 资助金额:
$ 36.12万 - 项目类别:
Pathways to New Biomarkers in Recurrent Abdominal Pain in Children
儿童复发性腹痛新生物标志物的途径
- 批准号:
8440046 - 财政年份:2012
- 资助金额:
$ 36.12万 - 项目类别:
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