Behavioral Consequences and cellular substrates of plasticity in visual cortex

视觉皮层可塑性的行为后果和细胞基质

• 批准号: 9624035
• 负责人: Mark F Bear
• 金额: $ 10.27万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9624035
• 关键词: Adult; Area; Behavior; Behavioral; Behavioral Assay; Brain; Characteristics; Chemosensitization; Exposure to; Form Perception; Goals; Head; Learning; Memory; Molecular; Mus; Neurobiology; Neurosciences; Perceptual Disorders; Perceptual learning; Physiological; Research; Research Project Grants; Sensory; Stimulus; Synapses; Visual; Visual Cortex; area striata; awake; experience; memory recognition; novel; response; visual stimulus

Central questions in the neurobiology of learning and memory are where and how experience modifies the brain to alter behavior. Recently we have described a physiological phenomenon in head-fixed awake mice termed stimulus-selective response potentiation (SRP), in which responsiveness of primary visual cortex is markedly enhanced as a result of repeated exposure to specific visual stimuli. This robust form of plasticity is induced and expressed in the adult primary visual cortex and displays many of the features that are characteristic of perceptual learning. The primary aims of this research are to; a) to determine the behavioral significance of SRP using two novel behavioral assays; b) determine how SRP is expressed at the cellular level within visual cortex and; c) pinpoint the synapses that are modified. Beyond the relevance of our proposed research to identifying the mechanisms underlying perceptual learning and/or visual recognition memory, they will broaden our understanding of how primary sensory areas are modified by sensory experience in order to modify behavior, which remains one of the great challenges in basic neuroscience.

学习和记忆的神经生物学的核心问题是在哪里以及如何