Development of a mobile health intervention for electronic cigarette use among young adults

开发针对年轻人电子烟使用的移动健康干预措施

• 批准号: 10449656
• 负责人: Emma Brett
• 金额: $ 17.28万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10449656
• 关键词: Abstinence; Address; Adolescence; Adverse effects; Affect; Area; Behavior; Behavioral; Biochemical; Cigarette; Clinical; Cognitive; Data; Dependence; Development; Devices; Drops; Education; Effectiveness; Electronic Nicotine Delivery Systems; Electronic cigarette; Feedback; Focus Groups; Frequencies; Funding; Health; Immersion; Individual; Intervention; Lead; Literature; Marijuana; Mentors; Mentorship; Modality; Motivation; Nicotine Dependence; Outcome; Participant; Pattern; Pharmacotherapy; Phase; Pilot Projects; Population; Prevalence; Randomized; Randomized Controlled Trials; Reporting; Research; Research Personnel; Resources; Running; Safety; Sampling; Schedule; Scientist; Smoking; Smoking Cessation Intervention; Text Messaging; Therapeutic Intervention; Time; Tobacco; Tobacco use; Training; Translations; Update; Work; Youth; acceptability and feasibility; addiction; addiction liability; base; behavior change; cancer risk; career; cigarette smoking; cigarette user; combustible cigarette; comparison intervention; cost; effective intervention; effective therapy; effectiveness evaluation; electronic cigarette use; epidemiologic data; evidence base; experience; follow up assessment; follow-up; interest; intervention effect; mHealth; new technology; nicotine replacement; nicotine use; novel; prevent; primary outcome; programs; randomized trial; recruit; secondary outcome; skills; smoking cessation; standard care; substance use; text messaging intervention; therapy development; tobacco control; tobacco products; tobacco user; uptake; vaping; web site; young adult

PROJECT ABSTRACT Despite declines in combustible cigarette smoking among young adults, use of electronic nicotine delivery systems (ENDS), such as e-cigarettes, continues to rise. Young adulthood marks a particularly susceptible time for the experimentation and initiation of substance use behaviors, including tobacco. Further, some who initiate tobacco use with ENDS transition to combustible products, such as cigarettes or marijuana, or become users of multiple products (dual/poly users). Despite the addiction potential of ENDS and high interest in quitting among young adults , there are few resources available to help individuals quit or reduce their use of ENDS. The aim of the proposed research is to develop an evidence-based mobile health (mHealth) text- message based intervention for young adult ENDS and dual (ENDS and cigarette) users (K99 phase 1), and determine whether the intervention is effective in reducing ENDS use (primary outcome) and increasing cessation , quit attempts, and use of nicotine replacement therapy (NRT; secondary outcomes; R00 phase 2). In phase 1 (K99), we will determine intervention content and delivery schedule based on existing evidence- based smoking cessation materials as well as utilize focus groups with young adult ENDS users (both ENDS- only and dual users) to adapt content to an mHealth ENDS-specific intervention. We will then run an initial pilot study with 45 participants to determine intervention feasibility and acceptability. After the pilot intervention, we will conduct additional focus groups with individuals who participated in the pilot to further refine the intervention. In phase 2 (R00), we will conduct a randomized control trial to determine the intervention’s effect on ENDS outcomes. Young adult ENDS and dual users will be randomized to one of three conditions: 1) mHealth ENDS intervention, 2) standard ENDS advice+NRT, or 3) standard advice alone . Standard advice will include a website that will be updated with information on products/safety and strategies for ENDS cessation as information evolves over the course of the study. Participants in the mHealth condition will complete a 6- week text-message based intervention with content tailored based on 1) motivation to quit ENDS, 2) whether an individual uses ENDS only or is a dual user of tobacco products, and 3) target quit date. Participants will complete an assessment of ENDS behaviors, quit attempts, and use of NRT at 3-month follow-up. ENDS use frequency will be the primary outcome , while biochemically verified 7-day point prevalence abstinence, NRT use, and quit attempts will be the secondary outcomes of interest. This study’s findings will inform emerging ENDS intervention literature, an area where a clear evidence base is currently lacking, and whether a mHealth intervention can impact young adults’ ENDS cessation, behaviors, and barriers to NRT use. This project will serve to provide valuable mentorship and training complementary to the proposed research to facilitate Dr. Brett’s transition to an independently-funded investigator and clinical addiction and tobacco control scientist.

项目摘要 尽管年轻人中吸烟混合吸烟，但使用电子尼古丁传递 系统（末端），例如电子烟，继续上升。年轻的成年标志着特别容易受到影响 实验和主动性的使用物质使用行为的时间，包括烟草。此外，有些人 启动烟草与末端过渡到混合产品，例如香烟或大麻，或成为 多个产品的用户（双/多用户）。尽管有末端的成瘾潜力 和对 年轻人退出 ，几乎没有资源可以帮助个人退出 或减少他们对 结束。拟议研究的目的是开发基于证据的移动健康（MHealth）文本 - 基于消息的年轻人干预措施和双重（末端和香烟）用户（K99阶段1），以及 确定干预是否有效 减少末端使用（主要结果）并增加 停止 ，退出尼古丁替代疗法的尝试和使用（NRT；第二结果； R00阶段2）。 在第1阶段（K99）中，我们将根据现有证据来确定干预内容和交付时间表 - 基于戒烟材料以及与年轻成人最终用户一起使用焦点小组（两者都 仅和双用户）将内容适应MHealth特定于特定的干预措施。然后，我们将运行初始飞行员 研究 45 参与者确定干预可行性和可接受性。飞行员干预后，我们 将与参加飞行员的个人进行其他焦点小组，以进一步完善 干涉。在第2阶段（R00）中，我们将进行一项随机控制试验以确定干预效果 在最终结果上。年轻的成人目的和双重用户将被随机分为 三 条件：1） MHealth结束了干预， 2）标准结束建议+NRT或3）单独使用标准建议 。标准建议将 包括一个网站，将更新有关产品/安全性和终点策略的信息 随着信息在研究过程中的发展。 MHealth条件下的参与者将完成6- 基于文本传语的一周基于基于1）辞职的内容的干预措施，2） 一个人仅使用末端或是烟草产品的双重用户，以及3）目标退出日期。参与者会 在3个月的随访中完成对目的行为的评估，退出尝试以及NRT的使用。结束 使用 频率将是主要结果 ，虽然生化验证的7天点场禁欲，但NRT 使用，退出尝试将是感兴趣的次要结果。这项研究的发现将为新兴 结束干预文献，目前缺乏明确证据基础的领域，以及MHealth是否 干预会影响年轻人的结束，行为和NRT使用的障碍。这个项目将 为拟议的研究提供有价值的精力和培训完整性，以促进博士。 布雷特（Brett）向独立资助的研究者和临床成瘾和烟草控制科学家的过渡。