Extreme weather-related events and environmental exposures in the risk for Alzheimer's disease and related dementias

极端天气相关事件和环境暴露会增加阿尔茨海默病和相关痴呆症的风险

• 批准号: 10449041
• 负责人: Kathryn C Conlon
• 金额: $ 76.81万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10449041
• 关键词: Address; Affect; African American population; Age; Aging; Air; Air Pollution; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Amyloid; Birth; Brain; Caliber; California; Cardiovascular Diseases; Chemicals; Cognition; Cognitive; Cohort Studies; Computerized Medical Record; Data; Development; Droughts; Elderly; Environment; Environmental Exposure; Environmental Pollution; Environmental Risk Factor; Ethnic Origin; Ethnic group; Etiology; Event; Exposure to; Frequencies; Funding; Goals; Impaired cognition; Incidence; Individual; Intervention; Lead; Life; Life Experience; Link; Literature; Longevity; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Mercury; Methodology; Modernization; National Institute on Aging; Neurocognitive; Neuropsychological Tests; Neurotoxins; Older Population; Outcome; Outcome Study; Particulate; Particulate Matter; Pattern; Persons; Population; Population Heterogeneity; Positron-Emission Tomography; Precision Health; Prevention; Public Health; Race; Recommendation; Recording of previous events; Research; Risk; Risk Factors; Role; Sampling; Severities; Strategic Planning; Stroke; Temperature; Testing; Time; Ultrafine; United States National Institutes of Health; Wildfire; advanced disease; aging brain; behavior measurement; cardiovascular risk factor; climate change; clinical examination; cognitive function; cohort; dementia risk; disorder prevention; environmental chemical; extreme heat; extreme weather; fine particles; health data; healthy aging; imaging biomarker; improved; modifiable risk; multidimensional data; neuroimaging; neuroimaging marker; prevent; psychosocial; racial and ethnic; study population; symposium; trend; ultrafine particle

PROJECT SUMMARY The 2018 National Institute on Aging AD Research Summit recommendation of “Understanding the Impact of the Environment to Advance Disease Prevention” as a key strategic plan to treat and prevent Alzheimer's Disease and related dementias (ADRD) by 2025. Exposure to extreme weather-related events, air pollution, and environmental contaminants are pervasive, yet little is known about their relationships with ADRD, especially among a diverse older population. The proposed study addresses critical gaps in the literature by linking residential history on a diverse sample of over 3,379 individuals from 3 ongoing NIH-funded cohort studies (Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE, n=1712, mean age 76.2, 71% non- White), the Study of Healthy Aging in African-Americans (STAR, n=764, mean age 68.4, 100% non-White) andLife After 90 (LA 90, n=903, mean age 92.7, 72% non-White)) to newly collected data on environmental exposures and will generate new granular, comprehensive, lifecourse measures of environmental exposures that will be used to examine their association with ADRD. All studies conduct harmonized neurocognitive assessments, clinical exams and neuroimaging, collect information on lifecourse risk factors, and are linked to health data (1960s-1990s) and electronic medical records (1996-present). Residential history at seven time points is collected (birth-current), and will be geocoded and linked to historic exposure data. The overall objective of this studyis to investigate exposure to extreme weather-related events, air pollution, and toxic environmental contaminants on cognitive function, ADRD, and neuroimaging biomarker in diverse aging populations. In a unique and unprecedented opportunity to comprehensively evaluate environmental exposures on late-life brainoutcomes, this study will address the following among 3,379 diverse Northern California residents: (1) Test the associations between exposure to extreme weather-related events (extreme heat, drought, wildfire) on neuroimaging markers, cognitive decline, and ADRD; (2) Determine the associations between exposure to ambient particulate air pollution (fine and ultrafine particulate matter (PM2.5, PM0.1)) on neuroimaging markers, cognitive decline, and ADRD; and (3) Assess the relationships between exposure to toxic environmental contaminants (lead, mercury) on neuroimaging markers, cognitive decline, and ADRD. Leveraging cumulative and time-dependent exposure to these environmental factors will illuminate lifecourse period in which exposureto these environmental factors is especially salient to healthy brain aging. Findings from this study have the potential to uncover new risk factors for ADRD and cognitive decline, and provide targets of ADRD interventionthat would improve healthy brain aging for people of all racial/ethnic groups.

项目概要 2018年美国国家老龄化研究所AD研究峰会推荐《Understanding the 环境对促进疾病预防的影响”作为治疗和预防疾病的关键战略计划 到 2025 年预防阿尔茨海默病和相关痴呆症 (ADRD)。 与天气相关的事件、空气污染和环境污染物普遍存在，但很少有 了解他们与 ADRD 的关系，尤其是在不同的老年人群中。这 拟议的研究通过将不同的居住历史联系起来，解决了文献中的关键空白 来自 NIH 资助的 3 项正在进行的队列研究（Kaiser Healthy Aging 和多样化的生活经历（KHANDLE，n=1712，平均年龄 76.2，71% 非白人），研究 非裔美国人的健康老龄化（STAR，n=764，平均年龄 68.4，100% 非白人）和之后的生活 90（洛杉矶 90，n=903，平均年龄 92.7，72% 非白人））到新收集的环境数据 并将产生新的细化、全面、生命周期的环境衡量标准 将用于检查其与 ADRD 关联的暴露。所有研究均进行 协调一致的神经认知评估、临床检查和神经影像学，收集有关 生命全程风险因素，并与健康数据（1960 年代至 1990 年代）和电子病历相关 （1996年至今）。收集七个时间点的居住史（出生至今），并将 地理编码并链接到历史暴露数据。本研究的总体目标是调查 暴露于极端天气相关事件、空气污染和有毒环境污染物 不同老龄人口中的认知功能、ADRD 和神经影像生物标志物。在一个独特的 以及全面评估晚年环境暴露的前所未有的机会 脑结果，这项研究将解决 3,379 名不同的北加州人的以下问题 居民：（1）测试暴露于极端天气相关事件（extreme 高温、干旱、野火）对神经影像标记、认知能力下降和 ADRD 的影响； (2) 确定 暴露于环境颗粒物空气污染（细颗粒物和超细颗粒物）之间的关联 物质（PM2.5、PM0.1））对神经影像标记物、认知能力下降和 ADRD 的影响； (3) 评估 接触有毒环境污染物（铅、汞）与 神经影像标记物、认知能力下降和 ADRD。利用累积和时间依赖性 暴露于这些环境因素将阐明暴露于这些环境因素的生命周期 环境因素对于健康的大脑老化尤其重要。这项研究的结果有 有可能发现 ADRD 和认知能力下降的新风险因素，并提供 ADRD 的目标 干预措施将改善所有种族/族裔群体的大脑健康老化。