Evaluating mechanisms of sex differences in environmentally-induced metabolic diseases

评估环境引起的代谢疾病中性别差异的机制

基本信息

  • 批准号:
    10449473
  • 负责人:
  • 金额:
    $ 12.62万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-06-03 至 2025-05-31
  • 项目状态:
    未结题

项目摘要

Mechanistic studies pertaining to sex-based differences in metabolic syndrome (MetS) are currently insufficient to explain and prevent the higher prevalence of certain MetS symptoms in women versus men and higher prevalence of other symptoms such as hyperlipidemia in men versus women. MetS describes a constellation of risk factors, such as abdominal adiposity, hypertension, glucose intolerance/hyperglycemia, and dyslipidemia, leading to diabetes and cardiovascular morbidity. High-caloric intake and sedentary lifestyle habits are among key players shown to induce symptoms of MetS. However, exposures to environmental chemicals such as persistent organic pollutants (POPs), often dictated by socio-economic status and education levels, have been increasingly identified as additional key players leading to MetS consequences. Previous studies showed that exposures to POPs, such as organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), in in-vivo models and human studies were associated with diabetes, obesity and non-alcoholic fatty liver disease, which are hallmarks for MetS development. Furthermore, using in- vitro models and diet-induced obesity mouse models, we had previously demonstrated that the liver was the predominant target organ of toxicity to POPs, including PCBs, and mechanism(s) of toxicity were primarily through activation of hepatic receptors leading to metabolic disruption. The liver has long been established as a sexually dimorphic organ and it is therefore important to address POPs toxicity in term of biological differences or sex. Additionally, POPs such as OCPs are endocrine disrupting chemicals, having the ability to interact with androgen or estrogen receptors, and potentially promoting variable effects in men and women. However, most epidemiologic studies demonstrating associations between POPs exposure with liver toxicity/metabolic diseases including diabetes either focused on agricultural workers who were mostly men or adjusted for sex; but POPs exposures occur in both men and women and thus their health risks may vary. POPs exposures today is primarily through ingestion of contaminated food and water, and serum levels can vary depending on sex and gender. Hence, it is relevant to examine exposures to POPs such as OCPs based on ‘environment-sex-gene’ interactions to better address such discrepancies.
有关代谢综合征(MetS)性别差异的机制研究目前尚不充分

项目成果

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Banrida Wahlang其他文献

Banrida Wahlang的其他文献

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{{ truncateString('Banrida Wahlang', 18)}}的其他基金

Evaluating mechanisms of sex differences in environmentally-induced metabolic diseases
评估环境引起的代谢疾病中性别差异的机制
  • 批准号:
    10818773
  • 财政年份:
    2022
  • 资助金额:
    $ 12.62万
  • 项目类别:
Evaluating mechanisms of sex differences in environmentally-induced metabolic diseases
评估环境引起的代谢疾病中性别差异的机制
  • 批准号:
    10634551
  • 财政年份:
    2022
  • 资助金额:
    $ 12.62万
  • 项目类别:

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