Mentoring in Musculoskeletal Pain Phenotypes

肌肉骨骼疼痛表型的指导

• 批准号: 10448742
• 负责人: Adam Goode
• 金额: $ 18.82万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-15 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10448742
• 关键词: Acute; Address; Affect; Area; Award; Biochemical; Biological; Biological Markers; Biomechanics; Career Mobility; Cartilage; Chronic; Chronic low back pain; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Complement; Data; Data Science; Development; Direct Costs; Discipline; Disease; Educational process of instructing; Electronic Health Record; Ensure; Environment; Epidemiology; Facilities and Administrative Costs; Fostering; Funding; Generations; Goals; Health; Health system; Healthcare; Healthcare Systems; Heterogeneity; High Prevalence; Image; Institutes; Intervertebral disc structure; Knee Osteoarthritis; Lead; Learning; Low Back Pain; Mechanics; Mentors; Mentorship; Methodology; Methods; Midcareer Investigator Award in Patient-Oriented Research; Musculoskeletal; Musculoskeletal Pain; Occupational Therapy; Orthopedic Surgery; Outcome; Pain; Pain Research; Pain management; Patients; Persons; Phenotype; Physical therapy; Physicians; Prevalence; Process; Quality of life; Request for Applications; Research; Research Design; Research Infrastructure; Research Institute; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk; Role; Scientist; Serum; Societies; Sociology; Strategic Planning; Time; Training; Training Programs; Translational Research; United States; United States National Institutes of Health; Universities; Urine; Vertebral column; Wages; Work; base; career; career development; chronic musculoskeletal pain; chronic pain; chronic painful condition; clinical care; clinical implementation; clinical pain; clinical phenotype; clinically significant; collaboratory; cost; design; experience; health care service utilization; innovation; medical schools; meniscus injury; mid-career faculty; multidisciplinary; next generation; opioid epidemic; pain chronification; patient oriented research; population health; pragmatic trial; predictive marker; prevent; programs; psychologic; rehabilitation research; skill acquisition; skills; systems research; tool; trial design; years lived with disability

PROJECT SUMMARY/ ABSTRACT This is a submission for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Adam Goode, is a clinician-scientist and Associate Professor in the Duke University Department of Orthopedic Surgery. Throughout his career, Dr. Goode has worked on epidemiological and mechanistic studies to better understand the heterogeneity that exists with low back pain and musculoskeletal conditions. These studies use advanced imaging and biochemical biomarkers found in serum and urine to characterize disease status and progression. These efforts have resulted in a current R01 Mechanical Biomarkers of Chronic Low Back Pain (AR075399) on advanced imaging of the intervertebral disc to characterize the role of mechanical strain with low back pain and a recently funded R01 Biological and Biomechanical Predictors of Cartilage Health Following Meniscus Injury (AR079184). These activities and projects engage a broad multidisciplinary team focused on advancing our understanding of low back pain, spine and knee OA in patient oriented research. The current application requests funding (50% salary support) for 5 years to support the protected time necessary to conduct the proposed patient oriented research and to expand opportunities for mentoring within the Duke University. This protected time will allow Dr. Goode to continue to lead a productive research group and maintain minimal teaching and administrative responsibility at the Departmental and University levels. As part of this application Dr. Goode will advance his epidemiological and mechanistic expertise by combining these areas with incorporating real world data to understand the health care utilization along with the transition from acute to chronic low back pain. There are plentiful opportunities to expand the work Dr. Goode has begun, and extremely high potential for clinical break-through in this important area of clinical research.

项目摘要/摘要这是一份以患者为导向的职业生涯中期调查员奖的提交材料 研究（K24）。申请人Adam Goode博士是杜克大学临床医生科学家兼副教授 骨科。在他的整个职业生涯中，古德博士一直致力于流行病学和机制研究 研究旨在更好地了解腰痛和肌肉骨骼疾病存在的异质性。这些研究 使用在血清和尿液中发现的先进成像和生化生物标志物来表征疾病状态和 进展。这些努力产生了当前的 R01 慢性腰痛机械生物标志物 (AR075399) 对椎间盘进行高级成像，以表征机械应变与腰痛和 最近资助的 R01 半月板损伤后软骨健康的生物和生物力学预测因子 （AR079184）。这些活动和项目吸引了广泛的多学科团队，致力于增进我们的理解 以患者为导向的研究中的腰痛、脊柱和膝关节 OA。当前申请请求资金（50％工资 支持）5年，以支持进行拟议的以患者为导向的研究所需的受保护时间，并 扩大杜克大学内部的指导机会。这段受保护的时间将使古德博士能够继续 领导一个富有成效的研究小组，并在院系和部门维持最低限度的教学和行政责任 大学水平。作为该应用程序的一部分，古德博士将通过以下方式提高他的流行病学和机制专业知识： 将这些领域与现实世界数据相结合，以了解医疗保健利用情况以及转型 从急性到慢性腰痛。有很多机会可以扩展古德博士已经开始的工作，并且 在这一重要的临床研究领域具有极高的临床突破潜力。