Mentoring in Musculoskeletal Pain Phenotypes

项目总结/摘要这是一份提交的职业中期研究者奖，以患者为导向 研究（K24）。申请人Adam Goode博士是杜克大学的临床科学家和副教授 骨科。在他的整个职业生涯中，古德博士一直致力于流行病学和机械 研究，以更好地了解下背痛和肌肉骨骼疾病的异质性。这些研究 使用血清和尿液中发现的先进成像和生化生物标志物来表征疾病状态， 进展这些努力产生了当前R 01慢性腰痛的机械生物标志物（AR 075399） 先进的椎间盘成像，以表征机械应变与腰痛的作用， 最近资助的R 01半月板损伤后腕关节健康的生物学和生物力学预测 （AR079184）。这些活动和项目涉及一个广泛的多学科团队，专注于推进我们的理解 下背痛，脊柱和膝关节OA的患者为导向的研究。当前应用程序请求资金（50%工资 支持）5年，以支持开展拟议的患者导向研究所需的受保护时间， 扩大在杜克大学的辅导机会。这段受保护的时间将允许古德博士继续 领导一个富有成效的研究小组，并保持最低限度的教学和行政责任，在部门和 大学水平。作为该应用程序的一部分，Goode博士将通过以下方式提高其流行病学和机理专业知识： 将这些领域与纳入真实的世界数据相结合，以了解医疗保健利用沿着转型 从急性到慢性腰痛。有很多机会来扩大古德博士已经开始的工作， 在这一重要的临床研究领域，具有极高的临床突破潜力。

PROJECT SUMMARY/ ABSTRACT This is a submission for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Adam Goode, is a clinician-scientist and Associate Professor in the Duke University Department of Orthopedic Surgery. Throughout his career, Dr. Goode has worked on epidemiological and mechanistic studies to better understand the heterogeneity that exists with low back pain and musculoskeletal conditions. These studies use advanced imaging and biochemical biomarkers found in serum and urine to characterize disease status and progression. These efforts have resulted in a current R01 Mechanical Biomarkers of Chronic Low Back Pain (AR075399) on advanced imaging of the intervertebral disc to characterize the role of mechanical strain with low back pain and a recently funded R01 Biological and Biomechanical Predictors of Cartilage Health Following Meniscus Injury (AR079184). These activities and projects engage a broad multidisciplinary team focused on advancing our understanding of low back pain, spine and knee OA in patient oriented research. The current application requests funding (50% salary support) for 5 years to support the protected time necessary to conduct the proposed patient oriented research and to expand opportunities for mentoring within the Duke University. This protected time will allow Dr. Goode to continue to lead a productive research group and maintain minimal teaching and administrative responsibility at the Departmental and University levels. As part of this application Dr. Goode will advance his epidemiological and mechanistic expertise by combining these areas with incorporating real world data to understand the health care utilization along with the transition from acute to chronic low back pain. There are plentiful opportunities to expand the work Dr. Goode has begun, and extremely high potential for clinical break-through in this important area of clinical research.