Longitudinal Sub-thalamic Structure and Functional Alterations in Mild Traumatic Brain Injury
轻度创伤性脑损伤的纵向下丘脑结构和功能改变
基本信息
- 批准号:10438832
- 负责人:
- 金额:$ 60.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-07-15 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAffectAnimalsApoptosisAreaAtlasesAtrophicAttentionBlood flowBrainBrain StemCadaverCell NucleusCerebral cortexCerebrovascular CirculationClassificationCognitionCognitiveCognitive deficitsCommunicationCommunitiesConsciousDataDevelopmentDiagnosisDiffuseDiffusionDizzinessEdemaFatigueFocal Brain InjuriesFunctional Magnetic Resonance ImagingFunctional disorderGoalsHeadacheHistologicHumanImageImpaired cognitionIndividualInflammationInjuryLanguageLocationLong-Term EffectsLongterm Follow-upMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMeasurementMeasuresMemoryMetabolismMethodologyMethodsMotorNeurobehavioral ManifestationsNeuropsychologyOrthopedicsPathologyPathway interactionsPatientsPerformancePersonsPhysiologic pulsePost-Concussion SyndromePredictive ValueResearchRestRoleRotationSensorySeriesSignal TransductionSleepSleeplessnessSpecificityStructureStructure of subthalamic nucleusSubthalamic structureTBI PatientsTechniquesTestingThalamic NucleiThalamic structureTimeTissuesTraumatic Brain InjuryUrsidae FamilyVisualizationautomated segmentationbasebiomarker discoveryblood leadbrain parenchymacontrast imagingeffectiveness evaluationexcitotoxicityexperiencehealthy volunteerimage registrationimaging modalityimprovedin vivoindividual patientinjuredinjury burdenmild traumatic brain injurymitochondrial dysfunctionmultimodalityneuroimagingnovelthalamocortical tracttractography
项目摘要
Project Summary
The thalamus is a relay station for all sensory pathways (except olfactory) to the cerebral cortex. It also regulates
sleep and consciousness, supports motor and language function and memory. Its role in cognition is also now increasingly
recognized. Given that it serves as a junction for ascending and descending cortical projections, it is likely that thalamus
may bear a significant burden of traumatic brain injury (TBI) irrespective of the precise location of physical injury
sustained. Thalamic injury may therefore underlie various persisting post-concussive symptoms and cognitive
impairment. Recently, our group has provided multiple lines of evidence including altered metabolism, altered tissue
microstructure and altered functional communication between various sub-thalamic regions and cortical regions
associated with sensory processing after TBI. Our results suggest that the structural and functional integrity of the
thalamus may serve as an important factor in the diagnosis and long-term follow-up of TBI patients. These studies have
examined the thalamus as a single structure, not as a composite of the various nuclei that reside within it. Recent research
has provided evidence that thalamic function is highly selective with individual nuclei performing discrete functions.
However, pinpointing injury to specific thalamic nuclei is challenging due to the lack of image contrast within the
thalamus. We therefore propose to develop novel MR imaging and multi-modal feature classification methods to segment
the thalamus into its individual nuclei and test the hypothesis that post traumatic alterations in the structural and functional
integrity of the thalamic nuclei will be associated with progression of specific neuropsychological and cognitive
symptoms after mild TBI. We will test this hypothesis through the following aims: (a) Develop and optimize technique to
generate a series of T1-based synthetic MPRAGE (SynMPRAGE) images for direct visualization of sub-thalamic nuclei,
(b) examine longitudinal structural alterations of the thalamus, and its connectivity on 100 mTBI patients in comparison
with orthopedically injured control subjects, and (c) examine longitudinal changes in resting state thalamic connectivity
following mTBI. Through the development of novel imaging methodology to directly identify thalamic nuclei and
through development and application of improved segmentation techniques using multi-modal classification methods, we
plan to understand the pathophysiology of the thalamus and predictive value of MRI measures of thalamic injury in the
development of neuropsychological and cognitive deficits in mTBI patients.
项目概要
丘脑是通往大脑皮层的所有感觉通路(嗅觉除外)的中继站。它还规范
睡眠和意识,支持运动和语言功能以及记忆。它在认知中的作用现在也越来越重要
认可。鉴于它是上升和下降皮质投射的连接点,丘脑很可能
无论身体损伤的精确位置如何,都可能承受创伤性脑损伤 (TBI) 的重大负担
持续。因此,丘脑损伤可能是各种持续性脑震荡后症状和认知障碍的基础。
损害。最近,我们的小组提供了多种证据,包括代谢改变、组织改变
不同丘脑下区域和皮质区域之间的微观结构和功能通讯的改变
与 TBI 后的感觉处理有关。我们的结果表明,结构和功能的完整性
丘脑可能作为 TBI 患者诊断和长期随访的重要因素。这些研究有
检查丘脑作为一个单一的结构,而不是作为驻留在其中的各种核的复合体。最近的研究
提供的证据表明,丘脑功能具有高度选择性,各个核团执行离散的功能。
然而,由于丘脑核内缺乏图像对比度,精确定位特定丘脑核的损伤具有挑战性。
丘脑。因此,我们建议开发新的 MR 成像和多模态特征分类方法来分割
丘脑进入其单个核并检验创伤后结构和功能发生变化的假设
丘脑核的完整性将与特定神经心理学和认知的进展相关
轻度 TBI 后的症状。我们将通过以下目标来检验这一假设: (a) 开发和优化技术
生成一系列基于 T1 的合成 MPRAGE (SynMPRAGE) 图像,用于丘脑下核的直接可视化,
(b) 检查 100 名 mTBI 患者的丘脑纵向结构变化及其连接性进行比较
与骨科受伤的对照受试者一起,以及(c)检查静息状态丘脑连接的纵向变化
继 mTBI 后。通过开发新颖的成像方法来直接识别丘脑核和
通过使用多模态分类方法改进分割技术的开发和应用,我们
计划了解丘脑的病理生理学以及 MRI 测量对丘脑损伤的预测价值
mTBI 患者神经心理和认知缺陷的发展。
项目成果
期刊论文数量(17)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Early Stage Longitudinal Subcortical Volumetric Changes following Mild Traumatic Brain Injury.
- DOI:10.1080/02699052.2021.1906445
- 发表时间:2021-05-12
- 期刊:
- 影响因子:1.9
- 作者:Zhuo J;Jiang L;Sours Rhodes C;Roys S;Shanmuganathan K;Chen H;Prince JL;Badjatia N;Gullapalli RP
- 通讯作者:Gullapalli RP
A Deep Learning Based Anti-aliasing Self Super-resolution Algorithm for MRI.
- DOI:10.1007/978-3-030-00928-1_12
- 发表时间:2018-09
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Hierarchical Parcellation of the Cerebellum.
小脑的分层分区。
- DOI:10.1007/978-3-030-32248-9_54
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Han,Shuo;Carass,Aaron;Prince,JerryL
- 通讯作者:Prince,JerryL
Prospective motion detection and re-acquisition in diffusion MRI using a phase image-based method-Application to brain and tongue imaging.
- DOI:10.1002/mrm.28729
- 发表时间:2021-08
- 期刊:
- 影响因子:3.3
- 作者:Liang, Xiao;Su, Pan;Patil, Sunil G.;Elsaid, Nahla M. H.;Roys, Steven;Stone, Maureen;Gullapalli, Rao P.;Prince, Jerry L.;Zhuo, Jiachen
- 通讯作者:Zhuo, Jiachen
Evaluating the impact of MR image harmonization on thalamus deep network segmentation.
评估 MR 图像协调对丘脑深度网络分割的影响。
- DOI:10.1117/12.2613159
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Shao,Muhan;Zuo,Lianrui;Carass,Aaron;Zhuo,Jiachen;Gullapalli,RaoP;Prince,JerryL
- 通讯作者:Prince,JerryL
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Neeraj Badjatia其他文献
Neeraj Badjatia的其他文献
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{{ truncateString('Neeraj Badjatia', 18)}}的其他基金
Longitudinal Sub-thalamic Structure and Functional Alterations in Mild Traumatic Brain Injury
轻度创伤性脑损伤的纵向下丘脑结构和功能改变
- 批准号:
10287719 - 财政年份:2018
- 资助金额:
$ 60.87万 - 项目类别:
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