Arousal-induced noradrenergic signaling modulates cortical astrocyte-neuron circuits during ethanol consumption
唤醒诱导的去甲肾上腺素能信号在乙醇消耗过程中调节皮质星形胶质细胞-神经元回路
基本信息
- 批准号:10369650
- 负责人:
- 金额:$ 18.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-03-14 至 2023-02-28
- 项目状态:已结题
- 来源:
- 关键词:Adrenergic ReceptorAffectAlcohol consumptionAlcoholsAnatomyAnimalsAnxietyArousalAstrocytesAxonBehaviorBrainCalciumCaliberCellsClinicalClinical TrialsCognitive ScienceColorCommunitiesConsumptionDevelopmentDiagnosisDiseaseDrug TargetingEthanolEventFellowshipFemaleFunctional disorderFutureGoalsGrantHeadHumanHyperactivityImageLeadLocomotionLongitudinal StudiesMeasuresMediatingMentorsMethodsMusNeuronsNorepinephrineNorepinephrine ReceptorsOpticsPathway interactionsPatientsPharmaceutical PreparationsPharmacologyPhasePhysiologyPost-Traumatic Stress DisordersPrefrontal CortexProcessPropertyPupilResearchResearch InfrastructureRewardsRoleSex DifferencesSignal TransductionStressStructureSubstance abuse problemTechniquesTestingTherapeuticTherapeutic EffectTrainingWakefulnessWorkalcohol behavioralcohol use disorderantagonistanxiety symptomscareercomorbiditydrinkingdrinking behaviorexperimental studyextracellularin vivoin vivo two-photon imaginginformation processinginhibitory neuroninsightmaleneuronal circuitryneurophysiologyneuroregulationnoradrenergicnoveloptogeneticsprogramsrelating to nervous systemresponsesensortwo photon microscopytwo-photon
项目摘要
My career goal is to lead an independent research program studying astrocyte-neuron dynamics,
arousal, and alcohol use disorder (AUD). I have benefitted from experimental training in numerous
techniques including two-photon microscopy, neurophysiology, circuit anatomy, and behavior. During
the mentored phase of this grant (K99), I will continue to work closely with my co-mentors, Drs.
Mriganka Sur and Elena Vazey. Mriganka is an expert in cortical information processing, neuron-
astrocyte circuits, and optical techniques. Elena Vazey is an expert in noradrenergic signaling, stress,
alcohol-related behaviors, and chemogenetics. In addition, I will receive advice from my mentoring team
consisting of Drs. Kerry Ressler, Heather Richardson, and Thomas Kash. Their combined expertise
ranges across stress pathophysiology, alcohol-related processing, limbic and reward circuits,
neuromodulation, and anxiety behaviors. The additional training from my mentoring team will equip me
with the conceptual and technical acumen to become a significant contributor to the fields of alcohol
behavior and stress. This training will be done within the Brain and Cognitive Sciences department at
MIT, which provides both a vibrant intellectual research community and expansive research
infrastructure support. During my postdoctoral fellowship, I developed novel methods of simultaneously
imaging astrocyte-neuron networks to study astrocyte roles in information processing. This work led
me to study how astrocytes affect neuromodulation of cortical circuits by norepinephrine (NE). I have
found an intriguing astrocyte-neuron calcium signature that reflects a shift in cortical processing during
periods of high arousal. Furthermore, the drugs that are currently being tested in arousal disorders and
AUD block these signatures, suggesting that astrocyte-neuron interactions may provide crucial insight
into the pathophysiology of stress and AUD. My immediate goals are to understand how these events
relate to arousal and alcohol drinking behavior, and to determine the relationship with abnormal NE
release. (Aim 1) I will study the astrocyte-neuron processing in the prefrontal cortex (PFC) while mice
actively drink alcohol on using in vivo two-photon imaging. (Aim 2) I will determine the role of NE in
affecting astrocyte-neuron physiology through pharmacological and chemogenetic manipulations of NE
release. (Aim 3) Finally, during R00 phase, I will manipulate astrocyte-specific mechanisms to
determine the role of astrocytes in arousal-mediated alcohol consumption. These experiments will
clarify how astrocyte-neuron dysregulation in the PFC is related to NE release and AUD.
我的职业目标是领导一个独立的研究项目,研究星形细胞-神经元动力学,
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Grayson Oren Sipe其他文献
Grayson Oren Sipe的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Grayson Oren Sipe', 18)}}的其他基金
Arousal-induced noradrenergic signaling modulates cortical astrocyte-neuron circuits during ethanol consumption
唤醒诱导的去甲肾上腺素能信号在乙醇消耗过程中调节皮质星形胶质细胞-神经元回路
- 批准号:
10831585 - 财政年份:2023
- 资助金额:
$ 18.56万 - 项目类别:
Role of P2Y12 and Purinergic Signaling in Microglia-Mediated Synaptic Plasticity
P2Y12 和嘌呤能信号在小胶质细胞介导的突触可塑性中的作用
- 批准号:
9015273 - 财政年份:2014
- 资助金额:
$ 18.56万 - 项目类别:
Role of P2Y12 and Purinergic Signaling in Microglia-Mediated Synaptic Plasticity
P2Y12 和嘌呤能信号在小胶质细胞介导的突触可塑性中的作用
- 批准号:
8712752 - 财政年份:2014
- 资助金额:
$ 18.56万 - 项目类别:
Role of P2Y12 and Purinergic Signaling in Microglia-Mediated Synaptic Plasticity
P2Y12 和嘌呤能信号在小胶质细胞介导的突触可塑性中的作用
- 批准号:
8819445 - 财政年份:2014
- 资助金额:
$ 18.56万 - 项目类别:
相似海外基金
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 18.56万 - 项目类别:
Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 18.56万 - 项目类别:
Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 18.56万 - 项目类别:
Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 18.56万 - 项目类别:
Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 18.56万 - 项目类别:
Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 18.56万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 18.56万 - 项目类别:
Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
- 批准号:
2301846 - 财政年份:2023
- 资助金额:
$ 18.56万 - 项目类别:
Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 18.56万 - 项目类别:
Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
- 批准号:
23K16076 - 财政年份:2023
- 资助金额:
$ 18.56万 - 项目类别:
Grant-in-Aid for Early-Career Scientists