Effects of a higher protein diet and resistance training on fat free mass retention during weight loss in adults over 50: A Pilot Sequential Multiple Assignment Randomized Trial

高蛋白饮食和阻力训练对 50 岁以上成年人减肥期间无脂肪质量保留的影响：一项试点序贯多重分配随机试验

• 批准号: 10369646
• 负责人: Richard Drew Sayer
• 金额: $ 12.94万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-10 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10369646
• 关键词: Activities of Daily Living; Address; Adherence; Adult; Aerobic; Aging; Alabama; Automobile Driving; Award; Balance training; Behavior; Behavior Therapy; Body Composition; Body Weight decreased; Body fat; Clinical; Clinical Trials; Consumption; Counseling; Data; Development; Diet; Dietary Intervention; Dietary Proteins; Education; Effectiveness of Interventions; Enrollment; Ensure; Equilibrium; Exercise; Fatty acid glycerol esters; Funding; Goals; Grant; Health; Individual; Intervention; Intervention Trial; Knowledge; Lead; Maintenance; Mentored Research Scientist Development Award; Mentors; Metabolic; Metabolic Diseases; Monitor; Obesity; Outcomes Research; Participant; Phase; Pilot Projects; Proteins; Race; Randomized; Research; Research Project Grants; Resistance; Resources; Role; Scientist; Sequential Multiple Assignment Randomized Trial; Sex Differences; Supervision; Supplementation; Testing; Training; United States National Institutes of Health; Universities; Weight; Whey Protein; Woman; Yoga; aged; base; biological sex; career; career development; community setting; design; dietary restriction; disorder risk; effectiveness research; exercise intervention; exercise prescription; exercise training; feasibility trial; flexibility; functional loss; improved; intervention effect; men; muscle form; nutrition; preference; preservation; prevent; programs; recruit; rehabilitation research; response; sarcopenia; sarcopenic obesity; secondary analysis; skeletal muscle wasting; skills; strength training; treatment strategy; trial design; weight loss intervention; weight loss program

PROJECT SUMMARY/ABSTRACT Dr. Sayer’s career goal is to become an independent translational obesity scientist at the University of Alabama at Birmingham (UAB) with a research program focused on the development of pragmatic and adaptive weight loss interventions that can be rapidly implemented in clinical and community settings. The proposed K01 training plan and research project will provide the knowledge, skills, and abilities to launch his independent research career in pursuit of his long-term goals. Dr. Sayer’s training plan includes a combination of formal didactic training available through the UAB Center for Outcomes and Effectiveness Research and Education (directed by Dr. Kenneth Saag, Co-Mentor) as well as rigorous hands-on and personalized training through the NIH National Rehabilitation Research Resource to Enhance Clinical Trials (directed by Dr. Marcas Bamman, Co-Mentor), UAB Nutrition Obesity Research Center (directed by Dr. James Hill, Primary Mentor), and UAB Comprehensive Center for Health Aging (directed by Dr. Cynthia Brow, Co-Mentor). The proposed K01 research is a pilot Sequential Multiple Assignment Randomized Trial (SMART) using a high protein diet and resistance training to promote the retention of fat free mass during weight loss in men with obesity aged 50 and older. The primary objectives of the research are to provide critical preliminary data on 1) the feasibility of conducting a full-scale SMART, 2) estimates of intervention effects and their variances, and 3) moderators or predictors of intervention responsiveness that may serve as tailoring variables for a full-scale SMART. Dr. Sayer will leverage data and training resulting from the proposed K01 to successfully compete for R01-level research funding to develop and rigorously evaluate a full-scale SMART designed to construct an optimal adaptive treatment strategy using a HP diet and RT for preventing and/or treating sarcopenic obesity.

项目总结/摘要 博士塞耶的职业目标是成为亚拉巴马大学的一名独立的肥胖科学家 伯明翰大学（UAB）的一个研究项目，重点是开发实用和自适应权重 可以在临床和社区环境中迅速实施的损失干预措施。K 01培训 计划和研究项目将提供知识，技能和能力，以启动他的独立研究 为了追求自己的长期目标。塞耶博士的培训计划包括正式的教学培训， 可通过UAB中心的成果和有效性研究和教育（由博士指导。 Kenneth Saag，Co-Mentor）以及通过NIH National 康复研究资源，以加强临床试验（由博士马卡斯巴曼，共同导师），UAB 营养肥胖研究中心（由James Hill博士指导，初级导师）和UAB综合 健康老龄化中心（由Cynthia Brow博士指导，共同导师）。拟议的K 01研究是一个试点 使用高蛋白饮食和阻力训练的序贯多分配随机试验（SMART）， 促进50岁及以上肥胖男性在减肥过程中保持无脂肪质量。主 该研究的目的是提供关键的初步数据1）进行全面的可行性， SMART，2）干预效果及其方差的估计，以及3）干预的调节因子或预测因子 响应性，可以作为一个全面的SMART定制变量。塞尔博士将利用数据， 由拟议的K 01产生的培训，以成功地竞争R 01级研究资金， 严格评估旨在使用HP构建最佳适应性治疗策略的全尺寸SMART 饮食和RT用于预防和/或治疗肌肉减少性肥胖。