Effects of a higher protein diet and resistance training on fat free mass retention during weight loss in adults over 50: A Pilot Sequential Multiple Assignment Randomized Trial

项目摘要/摘要 塞耶博士的职业目标是成为阿拉巴马大学的一名独立的转化型肥胖科学家 在伯明翰(UAB)，有一个研究项目，重点是开发实用和适应性权重 可在临床和社区环境中快速实施的丢失干预措施。拟议的K01培训 计划和研究项目将为他提供启动独立研究的知识、技能和能力 在追求长远目标的职业生涯中。Sayer博士的训练计划包括结合正规的教学训练 可通过UAB成果和有效性研究和教育中心(由Dr。 共同导师Kenneth Saag)，以及通过NIH National 加强临床试验的康复研究资源(由联合导师Marcas Bamman博士指导)，UAB 营养性肥胖研究中心(由首席导师詹姆斯·希尔博士指导)和UAB综合 健康老龄化中心(由共同导师辛西娅·布罗博士指导)。拟议的K01研究是一项试验性研究 使用高蛋白饮食和抵抗力训练的序贯多任务随机试验(SMART) 促进50岁及以上肥胖男性在减肥过程中保持无脂肪质量。初级阶段 这项研究的目标是提供关键的初步数据，1)进行全面 SMART，2)干预效果及其方差的估计，以及3)干预的调节因素或预测因素 可以作为全面智能的定制变量的响应性。塞耶博士将利用数据和 由建议的K01产生的培训，以成功竞争R01级别的研究资金，以开发和 严格评估旨在使用HP构建最佳适应性治疗策略的全面SMART 预防和/或治疗骨质疏松性肥胖的饮食和RT。

PROJECT SUMMARY/ABSTRACT Dr. Sayer’s career goal is to become an independent translational obesity scientist at the University of Alabama at Birmingham (UAB) with a research program focused on the development of pragmatic and adaptive weight loss interventions that can be rapidly implemented in clinical and community settings. The proposed K01 training plan and research project will provide the knowledge, skills, and abilities to launch his independent research career in pursuit of his long-term goals. Dr. Sayer’s training plan includes a combination of formal didactic training available through the UAB Center for Outcomes and Effectiveness Research and Education (directed by Dr. Kenneth Saag, Co-Mentor) as well as rigorous hands-on and personalized training through the NIH National Rehabilitation Research Resource to Enhance Clinical Trials (directed by Dr. Marcas Bamman, Co-Mentor), UAB Nutrition Obesity Research Center (directed by Dr. James Hill, Primary Mentor), and UAB Comprehensive Center for Health Aging (directed by Dr. Cynthia Brow, Co-Mentor). The proposed K01 research is a pilot Sequential Multiple Assignment Randomized Trial (SMART) using a high protein diet and resistance training to promote the retention of fat free mass during weight loss in men with obesity aged 50 and older. The primary objectives of the research are to provide critical preliminary data on 1) the feasibility of conducting a full-scale SMART, 2) estimates of intervention effects and their variances, and 3) moderators or predictors of intervention responsiveness that may serve as tailoring variables for a full-scale SMART. Dr. Sayer will leverage data and training resulting from the proposed K01 to successfully compete for R01-level research funding to develop and rigorously evaluate a full-scale SMART designed to construct an optimal adaptive treatment strategy using a HP diet and RT for preventing and/or treating sarcopenic obesity.