Palliative Care Research Cooperative Group (PCRC): Clinical Studies/Methodology Core

项目摘要/摘要 该U2C应用程序的主要目标是提高姑息治疗的工作效率和影响 研究合作小组(PCRC)，其能力促进进行高质量、有效的临床 研究，并扩大姑息治疗研究人员的数量和专业知识，进行多地点 临床试验。为了追求这些总体目标和目标，临床研究/方法学核心(CSMC)， 作为PCRC的四个核心之一，致力于为PCRC成员提供专业知识，以严格创建 设计姑息关怀研究和基于理论的有效行为干预。中国证监会的 具体目标是：(1)提供姑息治疗研究设计、多点试验和行为方面的专业知识 通过以下方式对PCRC成员进行干预：(A)确定回答研究问题的最佳研究设计 在相关情况下强调实用和/或创新设计；(B)促进与以下领域的专家协商 对调查员研究问题的答复，以及(C)为如何进行有特定重点的研究制定战略 关于代表性不足的少数群体和那些经济上处于不利地位的人，那些患有多种慢性疾病的人 条件和儿科人口；(2)改进和加强CSMC支持的 样本研究设计材料和行为干预研究方案和材料；(3)担任 调查人员的“第一站”，并将他们转介到其他三个核心(数据、信息学和统计； 测量；和护理人员研究)，以在咨询PCRC和 促进各核心之间的协同作用；以及(4)与调查员发展中心密切合作，以 通过以下方式指导和培训PCRC成员：(A)通过IDC举办网络研讨会 与研究设计、多点试验和行为干预有关，(B)作为促进者参与国际数据中心 加强临床试验，以及(C)开发侧重于设计问题的书面方法教程 尤其与姑息治疗研究有关。通过帮助调查人员完善他们的研究的严谨性， 培训研究人员，解决服务不足的人群，整个姑息治疗研究领域将 得到了加强。

PROJECT SUMMARY/ABSTRACT The primary goals of this U2C application are to increase the productivity and impact of the Palliative Care Research Cooperative Group (PCRC), its ability to facilitate the conduct of high-quality, effective clinical research, and to expand the number and expertise of palliative care researchers in conducting multi-site clinical trials. In pursuit of these overall goals and objectives, the Clinical Studies/Methodology Core (CSMC), one of four Cores within the PCRC, strives to provide expertise to PCRC members to create rigorously designed palliative care studies and theoretically-based effective behavioral interventions. The CSMC's specific aims are: (1) to provide expertise on palliative care study design, multi-site trials, and behavioral interventions for PCRC members by (a) identifying the best study design to answer the research question emphasizing pragmatic and/or innovative design when relevant, (b) facilitating consultation with experts in response to investigator research questions, and (c) strategizing how to conduct studies with a particular focus on underrepresented minorities and those who are economically disadvantaged, those with multiple chronic conditions, and pediatric populations; (2) to improve and build upon the CSMC-supported digital library of exemplar study design materials and behavioral intervention study protocols and materials; (3) to act as the “first stop” for investigators and refer them to the other three Cores (Data, Informatics, and Statistics; Measurement; and Caregiver Research) to create consistency among studies that consult the PCRC and promote synergy among the Cores; and (4) to work closely with the Investigator Development Center (IDC) to mentor and train PCRC members in palliative care research methods by (a) presenting Webinars via the IDC related to study design, multi-site trials, and behavioral interventions, (b) participating as Facilitators in the IDC Clinical Trials Intensives, and (c) developing written methodology tutorials focusing on design issues particularly relevant to palliative care research. By helping investigators refine the rigor of their research, training investigators, and addressing underserved populations, the entire palliative care research field will be strengthened.