Optical Functional Neuroimaging of Acute and Chronic Hypoxia

急性和慢性缺氧的光学功能神经影像

基本信息

  • 批准号:
    10448516
  • 负责人:
  • 金额:
    $ 16.86万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-07-01 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

Project Summary/Abstract I am a physician/scientist focusing on the development of optical neuroimaging techniques to improve bedside detection of neurologic injury in critically-ill children. The goal of my mentored career development award is to acquire training in mouse models of hypoxia as well as in advanced statistical methods for the analysis of resting-state brain activity. This training will launch an independent research career with the aim to bring imaging biomarkers from bench to bedside. Many pediatric diseases that were once universally fatal (e.g., complex congenital heart disease and extreme prematurity) now have relatively good survival rates. However, neurodevelopmental outcomes have improved only marginally. With timely intervention, it is possible to minimize hypoxic injury, but current bedside tools are insensitive and inadequate for this purpose. Furthermore, the heterogeneity of clinical populations limits clinical studies. Each patient has a unique injury and treatment, and neuroimaging is performed at varying times after injury; thus, it can be difficult to rigorously analyze such data to determine the best, most generalizable biomarkers. The present work aims to solve these problems by using mouse models of hypoxemic neurologic injury, robust statistical methods, optical functional neuroimaging techniques, and resting-state hemodynamic assessment (e.g., functional connectivity). The optical methods are similar to functional magnetic resonance imaging but have much lower cost, higher portability, and higher through-put. My proposal will test the hypothesis that resting-state hemodynamic metrics can serve as neuroimaging biomarkers of injury after acute and chronic hypoxia. Aim 1 will develop statistical methods adapted to optical neuroimaging to permit more robust noise filtering, brain segmentation, atlasing, and image analysis. Aim 2 will use resting-state hemodynamics in the hyperacute phase of ischemic stroke to identify the penumbra. Aim 3 will study the longitudinal development of functional connectivity networks across mouse development and the disruptive effects of chronic hypoxemia. This research will be conducted under the mentorship of Arjun Yodh, PhD, with co-mentorship by Daniel Licht, MD; both faculty are recognized leaders in the development of optical neuromonitoring techniques. In addition, I have assembled an interdisciplinary group of collaborators with expertise in mouse models of hypoxemia, neuroimaging statistics, and advanced network analysis methods. I will benefit from this excellent mentorship and research environment, and my unique optical neuroimaging methods offer a path to independence. I am a board-certified pediatric cardiologist, and my long-term career goals are to combine neuroimaging with a tenure-track position at a pediatric research hospital. The exceptional research environment at CHOP/Penn will enable future translational studies in the intensive care unit, as well as further animal models of disease. Page 1
项目总结/摘要 我是一名医生/科学家,专注于光学神经成像技术的发展,以改善 危重患儿神经损伤的床旁检测。我的指导职业发展奖的目标是 是获得训练的小鼠模型缺氧以及先进的统计方法的分析, 休息状态下的大脑活动这项培训将启动一个独立的研究生涯,目的是使成像 从实验室到床边的生物标志物。 许多曾经普遍致命的儿科疾病(例如,复杂先天性心脏病 早产儿)现在有相对较好的存活率。然而,神经发育结果有所改善, 只有一点点通过及时的干预,有可能将缺氧损伤降至最低,但目前的床边工具 对这一目的不敏感和不适当。此外,临床人群的异质性限制了临床 问题研究每个病人都有独特的损伤和治疗,神经成像是在不同的时间后进行的。 因此,很难严格分析这些数据,以确定最好的,最普遍的 生物标志物。 本工作旨在通过使用低氧性神经损伤的小鼠模型来解决这些问题, 稳健的统计方法、光学功能神经成像技术和静息态血流动力学 评估(例如,功能连接性)。光学方法类似于功能磁共振 成像,但具有低得多的成本、更高的便携性和更高的吞吐量。我的提议将检验 静息态血流动力学指标可以作为急性和慢性损伤后的神经影像学生物标志物, 缺氧目标1将开发适用于光学神经成像的统计方法,以允许更鲁棒的噪声 过滤、脑分割、图谱绘制和图像分析。Aim 2将使用静息态血流动力学 缺血性卒中的超急性期,以确定半暗带。目标3将研究 小鼠发育过程中的功能连接网络和慢性低氧血症的破坏性影响。 这项研究将在Arjun Yodh博士的指导下进行,丹尼尔将共同指导 Licht,医学博士;这两个教师都是公认的领导者在光学神经监测技术的发展。在 此外,我还组建了一个跨学科的合作者小组,他们在小鼠模型方面具有专业知识, 低氧血症、神经影像学统计和先进的网络分析方法。我将受益于这一优秀的 导师和研究环境,我独特的光学神经成像方法提供了一条途径, 独立我是一名经过认证的儿科心脏病专家,我的长期职业目标是将联合收割机 在儿科研究医院做神经影像学的终身教职卓越的研究环境 在CHOP/Penn的研究将使未来的转化研究在重症监护病房,以及进一步的动物模型, 疾病。 第1页

项目成果

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BRIAN Richard WHITE其他文献

BRIAN Richard WHITE的其他文献

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{{ truncateString('BRIAN Richard WHITE', 18)}}的其他基金

Optical Functional Neuroimaging of Acute and Chronic Hypoxia
急性和慢性缺氧的光学功能神经影像
  • 批准号:
    10202778
  • 财政年份:
    2020
  • 资助金额:
    $ 16.86万
  • 项目类别:
Optical Functional Neuroimaging of Acute and Chronic Hypoxia
急性和慢性缺氧的光学功能神经影像
  • 批准号:
    10038007
  • 财政年份:
    2020
  • 资助金额:
    $ 16.86万
  • 项目类别:
Optical Functional Neuroimaging of Acute and Chronic Hypoxia
急性和慢性缺氧的光学功能神经影像
  • 批准号:
    10646274
  • 财政年份:
    2020
  • 资助金额:
    $ 16.86万
  • 项目类别:

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